Immunoprofiling of leukemic stem cells CD34+/CD38−/CD123+ delineate FLT3/ITD-positive clones

Immunoprofiling of leukemic stem cells CD34+/CD38−/CD123+ delineate FLT3/ITD-positive clones

Abstract Background Acute myeloid leukemia (AML) is a heterogeneous clonal disorder presenting with accumulation of proliferating undifferentiated blasts. Xenograft transplantation studies have demonstrated a rare population of leukemia-initiating cells called leukemic stem cells (LSCs) capable of p...

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Bibliographic Details
Main Authors: Adhra Al-Mawali, David Gillis, Ian Lewis
Format: Article
Language:English
Published: BMC 2016-07-01
Series:Journal of Hematology & Oncology
Subjects:
Acute myeloid leukemia
FLT3/ITD
Leukemic stem cells
CD34+/CD38−/CD123+
Flow cytometry
Online Access:http://link.springer.com/article/10.1186/s13045-016-0292-z

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