Lipoprotein lipase and hepatic lipase
HDL subspecies Lp(A-I) and Lp(A-I,A-II) have different anti-atherogenic potentials. To determine the role of lipoprotein lipase (LPL) and hepatic lipase (HL) in regulating these particles, we measured these enzyme activities in 28 healthy subjects with well-controlled Type 1 diabetes, and studied th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2003-08-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520337652 |
| _version_ | 1818728232839544832 |
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| author | Marian C. Cheung Shalamar D. Sibley Jerry P. Palmer John F. Oram John D. Brunzell |
| author_facet | Marian C. Cheung Shalamar D. Sibley Jerry P. Palmer John F. Oram John D. Brunzell |
| author_sort | Marian C. Cheung |
| collection | DOAJ |
| description | HDL subspecies Lp(A-I) and Lp(A-I,A-II) have different anti-atherogenic potentials. To determine the role of lipoprotein lipase (LPL) and hepatic lipase (HL) in regulating these particles, we measured these enzyme activities in 28 healthy subjects with well-controlled Type 1 diabetes, and studied their relationship with Lp(A-I) and Lp(A-I,A-II). LPL was positively correlated with the apolipoprotein A-I (apoA-I), cholesterol, and phospholipid mass in total Lp(A-I), and with the apoA-I in large Lp(A-I) (r ≥ 0.58, P ≥ 0.001). HL was negatively correlated with all the above Lp(A-I) parameters plus Lp(A-I) triglyceride (r ≥ −0.53, P ≤ 0.003). No correlation was detected between LPL and Lp(A-I,A-II). However, HL was inversely correlated with total Lp(A-I,A-II) phospholipid, and with large Lp(A-I,A-II) (r ≥ 0.50, P ≤ 0.006). Similar studies were performed with phospholipid transfer protein (PLTP). Only total Lp(A-I) triglyceride in women (not men) (r = 0.71, P = 0.009) was significantly correlated with PLTP activity. These observations indicate that LPL and HL play major roles in determining the level and composition of plasma Lp(A-I), particularly large Lp(A-I), but not with Lp(A-I,A-II) level.Furthermore, select correlations of LPL and/or HL with the apoA-I, cholesterol, and triglyceride of Lp(A-I) but not Lp(A-I,A-II) imply that the apoA-I and lipid of Lp(A-I) and Lp(A-I,A-II) are not fully equilibrated. |
| first_indexed | 2024-12-17T22:26:44Z |
| format | Article |
| id | doaj.art-de9988d67e3e4da8b65da98b9df8927a |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T22:26:44Z |
| publishDate | 2003-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-de9988d67e3e4da8b65da98b9df8927a2022-12-21T21:30:19ZengElsevierJournal of Lipid Research0022-22752003-08-0144815521558Lipoprotein lipase and hepatic lipaseMarian C. Cheung0Shalamar D. Sibley1Jerry P. Palmer2John F. Oram3John D. Brunzell4Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA 98103; Veterans Administration, Puget Sound Health Care System, Seattle, WA 98108Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA 98103; Veterans Administration, Puget Sound Health Care System, Seattle, WA 98108Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA 98103; Veterans Administration, Puget Sound Health Care System, Seattle, WA 98108Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA 98103; Veterans Administration, Puget Sound Health Care System, Seattle, WA 98108Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA 98103; Veterans Administration, Puget Sound Health Care System, Seattle, WA 98108HDL subspecies Lp(A-I) and Lp(A-I,A-II) have different anti-atherogenic potentials. To determine the role of lipoprotein lipase (LPL) and hepatic lipase (HL) in regulating these particles, we measured these enzyme activities in 28 healthy subjects with well-controlled Type 1 diabetes, and studied their relationship with Lp(A-I) and Lp(A-I,A-II). LPL was positively correlated with the apolipoprotein A-I (apoA-I), cholesterol, and phospholipid mass in total Lp(A-I), and with the apoA-I in large Lp(A-I) (r ≥ 0.58, P ≥ 0.001). HL was negatively correlated with all the above Lp(A-I) parameters plus Lp(A-I) triglyceride (r ≥ −0.53, P ≤ 0.003). No correlation was detected between LPL and Lp(A-I,A-II). However, HL was inversely correlated with total Lp(A-I,A-II) phospholipid, and with large Lp(A-I,A-II) (r ≥ 0.50, P ≤ 0.006). Similar studies were performed with phospholipid transfer protein (PLTP). Only total Lp(A-I) triglyceride in women (not men) (r = 0.71, P = 0.009) was significantly correlated with PLTP activity. These observations indicate that LPL and HL play major roles in determining the level and composition of plasma Lp(A-I), particularly large Lp(A-I), but not with Lp(A-I,A-II) level.Furthermore, select correlations of LPL and/or HL with the apoA-I, cholesterol, and triglyceride of Lp(A-I) but not Lp(A-I,A-II) imply that the apoA-I and lipid of Lp(A-I) and Lp(A-I,A-II) are not fully equilibrated.http://www.sciencedirect.com/science/article/pii/S0022227520337652phospholipid transfer proteinhigh density lipoprotein size profileType 1 diabetes |
| spellingShingle | Marian C. Cheung Shalamar D. Sibley Jerry P. Palmer John F. Oram John D. Brunzell Lipoprotein lipase and hepatic lipase Journal of Lipid Research phospholipid transfer protein high density lipoprotein size profile Type 1 diabetes |
| title | Lipoprotein lipase and hepatic lipase |
| title_full | Lipoprotein lipase and hepatic lipase |
| title_fullStr | Lipoprotein lipase and hepatic lipase |
| title_full_unstemmed | Lipoprotein lipase and hepatic lipase |
| title_short | Lipoprotein lipase and hepatic lipase |
| title_sort | lipoprotein lipase and hepatic lipase |
| topic | phospholipid transfer protein high density lipoprotein size profile Type 1 diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520337652 |
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