Diagnostic accuracy of double inversion recovery in delineation of multiple sclerosis lesions and its clinical correlation with expanded disability scoring system
Abstract Background The aim of our work was to assess the diagnostic accuracy of a double inversion recovery (DIR) sequence in the detection of brain and spinal cord MS lesions. In addition, we aimed to evaluate the reliability of the correlation between GM affection and high Expanded Disability Sta...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-12-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43055-019-0057-0 |
| _version_ | 1819298680131289088 |
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| author | Weaam Hamed Wessam Fathi Walaa Mahmoud Galal Elhawary |
| author_facet | Weaam Hamed Wessam Fathi Walaa Mahmoud Galal Elhawary |
| author_sort | Weaam Hamed |
| collection | DOAJ |
| description | Abstract Background The aim of our work was to assess the diagnostic accuracy of a double inversion recovery (DIR) sequence in the detection of brain and spinal cord MS lesions. In addition, we aimed to evaluate the reliability of the correlation between GM affection and high Expanded Disability Status Scale (EDSS) to enhance the role of DIR as a practical test for clinical disability. Ninety MS patients were prospectively included in this study. Imaging was performed using Philips Intera 1.5 Tesla device. T2W-TSE, FLAIR, and DIR sequences were performed and compared to each other. Each patient was clinically assessed at the time of the MRI examination with EDSS. Results DIR showed significantly higher total lesion load in comparison to T2 and FLAIR with increased sensitivity for cortical lesion detection by DIR. There was a positive association between patients with cortical lesions and male gender, clinical disability, cognitive changes, and higher EDSS score. Conclusion The increased rate of cortical lesion detection by DIR does not affect its accuracy in white matter lesions count. Moreover, DIR provided a better morphological characterization and delineation of white matter lesion with good differentiation between juxtacortical and mixed white matter–gray matter lesions; thus, we recommend adding DIR sequence in routine MR protocols for MS patients. |
| first_indexed | 2024-12-24T05:33:45Z |
| format | Article |
| id | doaj.art-de9be3933a0843c68fa651e982cf9b62 |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-12-24T05:33:45Z |
| publishDate | 2019-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-de9be3933a0843c68fa651e982cf9b622022-12-21T17:13:05ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622019-12-015011810.1186/s43055-019-0057-0Diagnostic accuracy of double inversion recovery in delineation of multiple sclerosis lesions and its clinical correlation with expanded disability scoring systemWeaam Hamed0Wessam Fathi1Walaa Mahmoud2Galal Elhawary3Department of Diagnostic and Interventional Radiology, Faculty of Medicine, Mansoura UniversityDepartment of Neurology, Faculty of Medicine, Mansoura UniversityDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, Mansoura UniversityDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, Mansoura UniversityAbstract Background The aim of our work was to assess the diagnostic accuracy of a double inversion recovery (DIR) sequence in the detection of brain and spinal cord MS lesions. In addition, we aimed to evaluate the reliability of the correlation between GM affection and high Expanded Disability Status Scale (EDSS) to enhance the role of DIR as a practical test for clinical disability. Ninety MS patients were prospectively included in this study. Imaging was performed using Philips Intera 1.5 Tesla device. T2W-TSE, FLAIR, and DIR sequences were performed and compared to each other. Each patient was clinically assessed at the time of the MRI examination with EDSS. Results DIR showed significantly higher total lesion load in comparison to T2 and FLAIR with increased sensitivity for cortical lesion detection by DIR. There was a positive association between patients with cortical lesions and male gender, clinical disability, cognitive changes, and higher EDSS score. Conclusion The increased rate of cortical lesion detection by DIR does not affect its accuracy in white matter lesions count. Moreover, DIR provided a better morphological characterization and delineation of white matter lesion with good differentiation between juxtacortical and mixed white matter–gray matter lesions; thus, we recommend adding DIR sequence in routine MR protocols for MS patients.https://doi.org/10.1186/s43055-019-0057-0Double inversion recovery (DIR)Expanded disability status scale (EDSS)Multiple sclerosis (MS)Normal-appearing white matter (NAWM)Normal-appearing gray matter (NAGM) |
| spellingShingle | Weaam Hamed Wessam Fathi Walaa Mahmoud Galal Elhawary Diagnostic accuracy of double inversion recovery in delineation of multiple sclerosis lesions and its clinical correlation with expanded disability scoring system The Egyptian Journal of Radiology and Nuclear Medicine Double inversion recovery (DIR) Expanded disability status scale (EDSS) Multiple sclerosis (MS) Normal-appearing white matter (NAWM) Normal-appearing gray matter (NAGM) |
| title | Diagnostic accuracy of double inversion recovery in delineation of multiple sclerosis lesions and its clinical correlation with expanded disability scoring system |
| title_full | Diagnostic accuracy of double inversion recovery in delineation of multiple sclerosis lesions and its clinical correlation with expanded disability scoring system |
| title_fullStr | Diagnostic accuracy of double inversion recovery in delineation of multiple sclerosis lesions and its clinical correlation with expanded disability scoring system |
| title_full_unstemmed | Diagnostic accuracy of double inversion recovery in delineation of multiple sclerosis lesions and its clinical correlation with expanded disability scoring system |
| title_short | Diagnostic accuracy of double inversion recovery in delineation of multiple sclerosis lesions and its clinical correlation with expanded disability scoring system |
| title_sort | diagnostic accuracy of double inversion recovery in delineation of multiple sclerosis lesions and its clinical correlation with expanded disability scoring system |
| topic | Double inversion recovery (DIR) Expanded disability status scale (EDSS) Multiple sclerosis (MS) Normal-appearing white matter (NAWM) Normal-appearing gray matter (NAGM) |
| url | https://doi.org/10.1186/s43055-019-0057-0 |
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