Activation of α-, β-, γ- δ-, ζ- and η- class of carbonic anhydrases with amines and amino acids: a review
Eight genetically distinct carbonic anhydrase (EC 4.2.1.1) enzyme families (α-, β-, γ- δ-, ζ-, η-, θ- and ι-CAs) were described to date. On the other hand, 16 mammalian α-CA isoforms are known to be involved in many diseases such as glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pai...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14756366.2019.1664501 |
| _version_ | 1818317176868700160 |
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| author | Suleyman Akocak Claudiu T. Supuran |
| author_facet | Suleyman Akocak Claudiu T. Supuran |
| author_sort | Suleyman Akocak |
| collection | DOAJ |
| description | Eight genetically distinct carbonic anhydrase (EC 4.2.1.1) enzyme families (α-, β-, γ- δ-, ζ-, η-, θ- and ι-CAs) were described to date. On the other hand, 16 mammalian α-CA isoforms are known to be involved in many diseases such as glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, arthritis, neurodegeneration, etc. Although CA inhibitors were investigated for the management of a variety of such disorders, the activators just started to be investigated in detail for their in vivo effects. This review summarizes the activation profiles of α-, β, γ-, δ-, ζ- and η- CAs from various organisms (animals, fungi, protozoan, bacteria and archaea) with the most investigated classes of activators, the amines and the amino acids. |
| first_indexed | 2024-12-13T09:33:10Z |
| format | Article |
| id | doaj.art-de9bea0689034331a76a1e7fb2bc95d1 |
| institution | Directory Open Access Journal |
| issn | 1475-6366 1475-6374 |
| language | English |
| last_indexed | 2024-12-13T09:33:10Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Enzyme Inhibition and Medicinal Chemistry |
| spelling | doaj.art-de9bea0689034331a76a1e7fb2bc95d12022-12-21T23:52:26ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742019-01-013411652165910.1080/14756366.2019.16645011664501Activation of α-, β-, γ- δ-, ζ- and η- class of carbonic anhydrases with amines and amino acids: a reviewSuleyman Akocak0Claudiu T. Supuran1Adiyaman UniversityUniversità degli Studi di FirenzeEight genetically distinct carbonic anhydrase (EC 4.2.1.1) enzyme families (α-, β-, γ- δ-, ζ-, η-, θ- and ι-CAs) were described to date. On the other hand, 16 mammalian α-CA isoforms are known to be involved in many diseases such as glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, arthritis, neurodegeneration, etc. Although CA inhibitors were investigated for the management of a variety of such disorders, the activators just started to be investigated in detail for their in vivo effects. This review summarizes the activation profiles of α-, β, γ-, δ-, ζ- and η- CAs from various organisms (animals, fungi, protozoan, bacteria and archaea) with the most investigated classes of activators, the amines and the amino acids.http://dx.doi.org/10.1080/14756366.2019.1664501carbonic anhydraseactivatorisoformsneurodegenerativeproton shuttle |
| spellingShingle | Suleyman Akocak Claudiu T. Supuran Activation of α-, β-, γ- δ-, ζ- and η- class of carbonic anhydrases with amines and amino acids: a review Journal of Enzyme Inhibition and Medicinal Chemistry carbonic anhydrase activator isoforms neurodegenerative proton shuttle |
| title | Activation of α-, β-, γ- δ-, ζ- and η- class of carbonic anhydrases with amines and amino acids: a review |
| title_full | Activation of α-, β-, γ- δ-, ζ- and η- class of carbonic anhydrases with amines and amino acids: a review |
| title_fullStr | Activation of α-, β-, γ- δ-, ζ- and η- class of carbonic anhydrases with amines and amino acids: a review |
| title_full_unstemmed | Activation of α-, β-, γ- δ-, ζ- and η- class of carbonic anhydrases with amines and amino acids: a review |
| title_short | Activation of α-, β-, γ- δ-, ζ- and η- class of carbonic anhydrases with amines and amino acids: a review |
| title_sort | activation of α β γ δ ζ and η class of carbonic anhydrases with amines and amino acids a review |
| topic | carbonic anhydrase activator isoforms neurodegenerative proton shuttle |
| url | http://dx.doi.org/10.1080/14756366.2019.1664501 |
| work_keys_str_mv | AT suleymanakocak activationofabgdzandēclassofcarbonicanhydraseswithaminesandaminoacidsareview AT claudiutsupuran activationofabgdzandēclassofcarbonicanhydraseswithaminesandaminoacidsareview |