Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth
Human milk oligosaccharides (HMOs) are bioactive molecules playing a critical role in infant health. We aimed to quantify the composition of HMOs of women with normal weight (18.5–24.9 kg/m<sup>2</sup>), overweight (25.0–29.9 kg/m<sup>2</sup>), or obesity (30.0–60.0 kg/m<s...
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MDPI AG
2021-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/2/446 |
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| author | Jessica L. Saben Clark R. Sims Ann Abraham Lars Bode Aline Andres |
| author_facet | Jessica L. Saben Clark R. Sims Ann Abraham Lars Bode Aline Andres |
| author_sort | Jessica L. Saben |
| collection | DOAJ |
| description | Human milk oligosaccharides (HMOs) are bioactive molecules playing a critical role in infant health. We aimed to quantify the composition of HMOs of women with normal weight (18.5–24.9 kg/m<sup>2</sup>), overweight (25.0–29.9 kg/m<sup>2</sup>), or obesity (30.0–60.0 kg/m<sup>2</sup>) and determine the effect of HMO intake on infant growth. Human milk (HM) samples collected at 2 months (2 M; <i>n</i> = 194) postpartum were analyzed for HMO concentrations via high-performance liquid chromatography. Infant HM intake, anthropometrics and body composition were assessed at 2 M and 6 M postpartum. Linear regressions and linear mixed-effects models were conducted examining the relationships between maternal BMI and HMO composition and HMO intake and infant growth over the first 6 M, respectively. Maternal obesity was associated with lower concentrations of several fucosylated and sialylated HMOs and infants born to women with obesity had lower intakes of these HMOs. Maternal BMI was positively associated with lacto-N-neotetraose, 3-fucosyllactose, 3-sialyllactose and 6-sialyllactose and negatively associated with disialyllacto-N-tetraose, disialyllacto-N-hexaose, fucodisialyllacto-N-hexaose and total acidic HMOs concentrations at 2 M. Infant intakes of 3-fucosyllactose, 3-sialyllactose, 6-sialyllactose, disialyllacto-N-tetraose, disialyllacto-N-hexaose, and total acidic HMOs were positively associated with infant growth over the first 6 M of life. Maternal obesity is associated with changes in HMO concentrations that are associated with infant adiposity. |
| first_indexed | 2024-03-09T03:19:51Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T03:19:51Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-de9d7c50ff75499989d2d63eae8ca5d02023-12-03T15:13:04ZengMDPI AGNutrients2072-66432021-01-0113244610.3390/nu13020446Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant GrowthJessica L. Saben0Clark R. Sims1Ann Abraham2Lars Bode3Aline Andres4J.L.S. Scientific Consulting, L.L.C., Thornton, CO 80229, USAArkansas Children’s Nutrition Center, Little Rock, AR 72202, USALarsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USALarsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USAArkansas Children’s Nutrition Center, Little Rock, AR 72202, USAHuman milk oligosaccharides (HMOs) are bioactive molecules playing a critical role in infant health. We aimed to quantify the composition of HMOs of women with normal weight (18.5–24.9 kg/m<sup>2</sup>), overweight (25.0–29.9 kg/m<sup>2</sup>), or obesity (30.0–60.0 kg/m<sup>2</sup>) and determine the effect of HMO intake on infant growth. Human milk (HM) samples collected at 2 months (2 M; <i>n</i> = 194) postpartum were analyzed for HMO concentrations via high-performance liquid chromatography. Infant HM intake, anthropometrics and body composition were assessed at 2 M and 6 M postpartum. Linear regressions and linear mixed-effects models were conducted examining the relationships between maternal BMI and HMO composition and HMO intake and infant growth over the first 6 M, respectively. Maternal obesity was associated with lower concentrations of several fucosylated and sialylated HMOs and infants born to women with obesity had lower intakes of these HMOs. Maternal BMI was positively associated with lacto-N-neotetraose, 3-fucosyllactose, 3-sialyllactose and 6-sialyllactose and negatively associated with disialyllacto-N-tetraose, disialyllacto-N-hexaose, fucodisialyllacto-N-hexaose and total acidic HMOs concentrations at 2 M. Infant intakes of 3-fucosyllactose, 3-sialyllactose, 6-sialyllactose, disialyllacto-N-tetraose, disialyllacto-N-hexaose, and total acidic HMOs were positively associated with infant growth over the first 6 M of life. Maternal obesity is associated with changes in HMO concentrations that are associated with infant adiposity.https://www.mdpi.com/2072-6643/13/2/446lactationHMOmaternal obesitybreastfeedingbreastmilkDOHaD |
| spellingShingle | Jessica L. Saben Clark R. Sims Ann Abraham Lars Bode Aline Andres Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth Nutrients lactation HMO maternal obesity breastfeeding breastmilk DOHaD |
| title | Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth |
| title_full | Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth |
| title_fullStr | Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth |
| title_full_unstemmed | Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth |
| title_short | Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth |
| title_sort | human milk oligosaccharide concentrations and infant intakes are associated with maternal overweight and obesity and predict infant growth |
| topic | lactation HMO maternal obesity breastfeeding breastmilk DOHaD |
| url | https://www.mdpi.com/2072-6643/13/2/446 |
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