Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss

Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss

Summary: SARM1 is an inducible TIR-domain NAD+ hydrolase that mediates pathological axon degeneration. SARM1 is activated by an increased ratio of NMN to NAD+, which competes for binding to an allosteric activating site. When NMN binds, the TIR domain is released from autoinhibition, activating its...

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Bibliographic Details
Main Authors: Tong Wu, Jian Zhu, Amy Strickland, Kwang Woo Ko, Yo Sasaki, Caitlin B. Dingwall, Yurie Yamada, Matthew D. Figley, Xianrong Mao, Alicia Neiner, A. Joseph Bloom, Aaron DiAntonio, Jeffrey Milbrandt
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
base exchange reaction
mass spectrometry
metabolism
NAMPT
NMNAT
Vacor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721013395

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