Whole body‐diffusion weighted imaging for the assessment of treatment response in hairy cell leukaemia: A positive first step
Abstract We present the case of a patient diagnosed with hairy cell leukaemia (HCL) who subsequently developed biopsy confirmed bone lesions and underwent multiple lines of therapy. The reported incidence of bone lesions in HCL is 3%, and bony involvement can be associated with high tumour burden an...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-05-01
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| Series: | eJHaem |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jha2.158 |
| _version_ | 1797740069296013312 |
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| author | Ashwin Algudkar Dima El‐Sharkawi Matthew Cross Nina Tunariu Ayoma D Attygalle Bhupinder Sharma |
| author_facet | Ashwin Algudkar Dima El‐Sharkawi Matthew Cross Nina Tunariu Ayoma D Attygalle Bhupinder Sharma |
| author_sort | Ashwin Algudkar |
| collection | DOAJ |
| description | Abstract We present the case of a patient diagnosed with hairy cell leukaemia (HCL) who subsequently developed biopsy confirmed bone lesions and underwent multiple lines of therapy. The reported incidence of bone lesions in HCL is 3%, and bony involvement can be associated with high tumour burden and aggressive disease. The commonly lytic bone lesions in HCL are difficult to accurately assess for response. Whole body diffusion weighted imaging (WB‐DWI) has been used clinically in multiple myeloma; we postulate clinical utility in HCL, where hypercellularity also applies. In our case, WB‐DWI appears to discriminate sites of active disease from bone response. We present the salient radiological and pathological images. To our knowledge, this is the first description of WB‐DWI in HCL; we support research of WB‐DWI in the staging, prognostication and response assessment of HCL. |
| first_indexed | 2024-03-12T14:07:09Z |
| format | Article |
| id | doaj.art-dea16932c96b41f4abb54e4271a61976 |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-03-12T14:07:09Z |
| publishDate | 2021-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-dea16932c96b41f4abb54e4271a619762023-08-21T14:06:07ZengWileyeJHaem2688-61462021-05-012231131210.1002/jha2.158Whole body‐diffusion weighted imaging for the assessment of treatment response in hairy cell leukaemia: A positive first stepAshwin Algudkar0Dima El‐Sharkawi1Matthew Cross2Nina Tunariu3Ayoma D Attygalle4Bhupinder Sharma5The Royal Marsden Hospital London UKThe Royal Marsden Hospital London UKThe Royal Marsden Hospital London UKThe Royal Marsden Hospital London UKThe Royal Marsden Hospital London UKThe Royal Marsden Hospital London UKAbstract We present the case of a patient diagnosed with hairy cell leukaemia (HCL) who subsequently developed biopsy confirmed bone lesions and underwent multiple lines of therapy. The reported incidence of bone lesions in HCL is 3%, and bony involvement can be associated with high tumour burden and aggressive disease. The commonly lytic bone lesions in HCL are difficult to accurately assess for response. Whole body diffusion weighted imaging (WB‐DWI) has been used clinically in multiple myeloma; we postulate clinical utility in HCL, where hypercellularity also applies. In our case, WB‐DWI appears to discriminate sites of active disease from bone response. We present the salient radiological and pathological images. To our knowledge, this is the first description of WB‐DWI in HCL; we support research of WB‐DWI in the staging, prognostication and response assessment of HCL.https://doi.org/10.1002/jha2.158hairy cell leukaemiaimagingMRI |
| spellingShingle | Ashwin Algudkar Dima El‐Sharkawi Matthew Cross Nina Tunariu Ayoma D Attygalle Bhupinder Sharma Whole body‐diffusion weighted imaging for the assessment of treatment response in hairy cell leukaemia: A positive first step eJHaem hairy cell leukaemia imaging MRI |
| title | Whole body‐diffusion weighted imaging for the assessment of treatment response in hairy cell leukaemia: A positive first step |
| title_full | Whole body‐diffusion weighted imaging for the assessment of treatment response in hairy cell leukaemia: A positive first step |
| title_fullStr | Whole body‐diffusion weighted imaging for the assessment of treatment response in hairy cell leukaemia: A positive first step |
| title_full_unstemmed | Whole body‐diffusion weighted imaging for the assessment of treatment response in hairy cell leukaemia: A positive first step |
| title_short | Whole body‐diffusion weighted imaging for the assessment of treatment response in hairy cell leukaemia: A positive first step |
| title_sort | whole body diffusion weighted imaging for the assessment of treatment response in hairy cell leukaemia a positive first step |
| topic | hairy cell leukaemia imaging MRI |
| url | https://doi.org/10.1002/jha2.158 |
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