In vivo vesicular acetylcholine transporter density in human peripheral organs: an [18F]FEOBV PET/CT study
Abstract Background The autonomic nervous system is frequently affected in some neurodegenerative diseases, including Parkinson’s disease and Dementia with Lewy bodies. In vivo imaging methods to visualize and quantify the peripheral cholinergic nervous system are lacking. By using [18F]FEOBV PET, w...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-04-01
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| Series: | EJNMMI Research |
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| Online Access: | https://doi.org/10.1186/s13550-022-00889-9 |
| _version_ | 1818645298075926528 |
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| author | Jacob Horsager Niels Okkels Nathalie Van Den Berge Jan Jacobsen Anna Schact Ole Lajord Munk Kim Vang Dirk Bender David J. Brooks Per Borghammer |
| author_facet | Jacob Horsager Niels Okkels Nathalie Van Den Berge Jan Jacobsen Anna Schact Ole Lajord Munk Kim Vang Dirk Bender David J. Brooks Per Borghammer |
| author_sort | Jacob Horsager |
| collection | DOAJ |
| description | Abstract Background The autonomic nervous system is frequently affected in some neurodegenerative diseases, including Parkinson’s disease and Dementia with Lewy bodies. In vivo imaging methods to visualize and quantify the peripheral cholinergic nervous system are lacking. By using [18F]FEOBV PET, we here describe the peripheral distribution of the specific cholinergic marker, vesicular acetylcholine transporters (VAChT), in human subjects. We included 15 healthy subjects aged 53–86 years for 70 min dynamic PET protocol of peripheral organs. We performed kinetic modelling of the adrenal gland, pancreas, myocardium, renal cortex, spleen, colon, and muscle using an image-derived input function from the aorta. A metabolite correction model was generated from venous blood samples. Three non-linear compartment models were tested. Additional time-activity curves from 6 to 70 min post injection were generated for prostate, thyroid, submandibular-, parotid-, and lacrimal glands. Results A one-tissue compartment model generated the most robust fits to the data. Total volume-of-distribution rank order was: adrenal gland > pancreas > myocardium > spleen > renal cortex > muscle > colon. We found significant linear correlations between total volumes-of-distribution and standard uptake values in most organs. Conclusion High [18F]FEOBV PET signal was found in structures with known cholinergic activity. We conclude that [18F]FEOBV PET is a valid tool for estimating VAChT density in human peripheral organs. Simple static images may replace kinetic modeling in some organs and significantly shorten scan duration. Clinical Trial Registration Trial registration: NCT, NCT03554551. Registered 31 May 2018. https://clinicaltrials.gov/ct2/show/NCT03554551?term=NCT03554551&draw=2&rank=1 . |
| first_indexed | 2024-12-17T00:28:31Z |
| format | Article |
| id | doaj.art-dea18ac0e9764365a8f638a14a74f226 |
| institution | Directory Open Access Journal |
| issn | 2191-219X |
| language | English |
| last_indexed | 2024-12-17T00:28:31Z |
| publishDate | 2022-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj.art-dea18ac0e9764365a8f638a14a74f2262022-12-21T22:10:24ZengSpringerOpenEJNMMI Research2191-219X2022-04-0112111110.1186/s13550-022-00889-9In vivo vesicular acetylcholine transporter density in human peripheral organs: an [18F]FEOBV PET/CT studyJacob Horsager0Niels Okkels1Nathalie Van Den Berge2Jan Jacobsen3Anna Schact4Ole Lajord Munk5Kim Vang6Dirk Bender7David J. Brooks8Per Borghammer9Department of Nuclear Medicine and PET, Aarhus University HospitalDepartment of Nuclear Medicine and PET, Aarhus University HospitalDepartment of Nuclear Medicine and PET, Aarhus University HospitalDepartment of Nuclear Medicine and PET, Aarhus University HospitalDepartment of Nuclear Medicine and PET, Aarhus University HospitalDepartment of Nuclear Medicine and PET, Aarhus University HospitalDepartment of Nuclear Medicine and PET, Aarhus University HospitalDepartment of Nuclear Medicine and PET, Aarhus University HospitalDepartment of Nuclear Medicine and PET, Aarhus University HospitalDepartment of Nuclear Medicine and PET, Aarhus University HospitalAbstract Background The autonomic nervous system is frequently affected in some neurodegenerative diseases, including Parkinson’s disease and Dementia with Lewy bodies. In vivo imaging methods to visualize and quantify the peripheral cholinergic nervous system are lacking. By using [18F]FEOBV PET, we here describe the peripheral distribution of the specific cholinergic marker, vesicular acetylcholine transporters (VAChT), in human subjects. We included 15 healthy subjects aged 53–86 years for 70 min dynamic PET protocol of peripheral organs. We performed kinetic modelling of the adrenal gland, pancreas, myocardium, renal cortex, spleen, colon, and muscle using an image-derived input function from the aorta. A metabolite correction model was generated from venous blood samples. Three non-linear compartment models were tested. Additional time-activity curves from 6 to 70 min post injection were generated for prostate, thyroid, submandibular-, parotid-, and lacrimal glands. Results A one-tissue compartment model generated the most robust fits to the data. Total volume-of-distribution rank order was: adrenal gland > pancreas > myocardium > spleen > renal cortex > muscle > colon. We found significant linear correlations between total volumes-of-distribution and standard uptake values in most organs. Conclusion High [18F]FEOBV PET signal was found in structures with known cholinergic activity. We conclude that [18F]FEOBV PET is a valid tool for estimating VAChT density in human peripheral organs. Simple static images may replace kinetic modeling in some organs and significantly shorten scan duration. Clinical Trial Registration Trial registration: NCT, NCT03554551. Registered 31 May 2018. https://clinicaltrials.gov/ct2/show/NCT03554551?term=NCT03554551&draw=2&rank=1 .https://doi.org/10.1186/s13550-022-00889-9VAChTVesicular acetylcholine transporterCholinergic neuronsParasympathetic nervous systemPET imaging[18F]FEOBV |
| spellingShingle | Jacob Horsager Niels Okkels Nathalie Van Den Berge Jan Jacobsen Anna Schact Ole Lajord Munk Kim Vang Dirk Bender David J. Brooks Per Borghammer In vivo vesicular acetylcholine transporter density in human peripheral organs: an [18F]FEOBV PET/CT study EJNMMI Research VAChT Vesicular acetylcholine transporter Cholinergic neurons Parasympathetic nervous system PET imaging [18F]FEOBV |
| title | In vivo vesicular acetylcholine transporter density in human peripheral organs: an [18F]FEOBV PET/CT study |
| title_full | In vivo vesicular acetylcholine transporter density in human peripheral organs: an [18F]FEOBV PET/CT study |
| title_fullStr | In vivo vesicular acetylcholine transporter density in human peripheral organs: an [18F]FEOBV PET/CT study |
| title_full_unstemmed | In vivo vesicular acetylcholine transporter density in human peripheral organs: an [18F]FEOBV PET/CT study |
| title_short | In vivo vesicular acetylcholine transporter density in human peripheral organs: an [18F]FEOBV PET/CT study |
| title_sort | in vivo vesicular acetylcholine transporter density in human peripheral organs an 18f feobv pet ct study |
| topic | VAChT Vesicular acetylcholine transporter Cholinergic neurons Parasympathetic nervous system PET imaging [18F]FEOBV |
| url | https://doi.org/10.1186/s13550-022-00889-9 |
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