Correlations between OCT4 Expression and Clinicopathological Factors and Prognosis of Patients with Lung Adenocarcinoma
Background and objective In recent years, cases of lung adenocarcinoma morbidity have consistently grown. OCT4 is the key gene that controls the automatic renewal of stem cells, and regulates the proliferation and differentiation of cancer stem cells. The aim of this study is to detect OCT4 expressi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2013-04-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2013.04.05 |
| _version_ | 1818941231164555264 |
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| author | Xueyan ZHANG Huimin WANG Bo JIN Qianggang DONG Jinsu HUANG Baohui HAN |
| author_facet | Xueyan ZHANG Huimin WANG Bo JIN Qianggang DONG Jinsu HUANG Baohui HAN |
| author_sort | Xueyan ZHANG |
| collection | DOAJ |
| description | Background and objective In recent years, cases of lung adenocarcinoma morbidity have consistently grown. OCT4 is the key gene that controls the automatic renewal of stem cells, and regulates the proliferation and differentiation of cancer stem cells. The aim of this study is to detect OCT4 expression in lung adenocarcinoma tissues, and to evaluate its relevance in the metastasis, chemotherapeutic effect, and prognosis in lung adenocarcinoma patients. Methods Immunofluorescence method was employed to detect OCT4 expression in lung adenocarcinoma tissues. The relationship between OCT4 expression and clinical pathological indicators is examined through chi-square test. Moreover, the survival rate is calculated through the Kaplan-Meier survivorship curve. Finally, the relevance between the indicators and patient survival is estimated using Cox analysis. Results Among the 126 tissue samples of lung adenocarcinoma, 91 showed OCT4 positive cells. OCT4 expression is closely related to metastasis and chemoresistance in lung adenocarcinoma patients, and negatively corresponds to the patients’ disease-free survival and survival periods. Conclusion OCT4 expression is related to metastasis and chemoresistance in lung adenocarcinoma patients, and thus indicates poor prognosis. |
| first_indexed | 2024-12-20T06:52:15Z |
| format | Article |
| id | doaj.art-dea364d67d2b4712bf15268001e8cb54 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-20T06:52:15Z |
| publishDate | 2013-04-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-dea364d67d2b4712bf15268001e8cb542022-12-21T19:49:31ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872013-04-0116419720210.3779/j.issn.1009-3419.2013.04.05Correlations between OCT4 Expression and Clinicopathological Factors
and Prognosis of Patients with Lung AdenocarcinomaXueyan ZHANGHuimin WANGBo JINQianggang DONGJinsu HUANGBaohui HANBackground and objective In recent years, cases of lung adenocarcinoma morbidity have consistently grown. OCT4 is the key gene that controls the automatic renewal of stem cells, and regulates the proliferation and differentiation of cancer stem cells. The aim of this study is to detect OCT4 expression in lung adenocarcinoma tissues, and to evaluate its relevance in the metastasis, chemotherapeutic effect, and prognosis in lung adenocarcinoma patients. Methods Immunofluorescence method was employed to detect OCT4 expression in lung adenocarcinoma tissues. The relationship between OCT4 expression and clinical pathological indicators is examined through chi-square test. Moreover, the survival rate is calculated through the Kaplan-Meier survivorship curve. Finally, the relevance between the indicators and patient survival is estimated using Cox analysis. Results Among the 126 tissue samples of lung adenocarcinoma, 91 showed OCT4 positive cells. OCT4 expression is closely related to metastasis and chemoresistance in lung adenocarcinoma patients, and negatively corresponds to the patients’ disease-free survival and survival periods. Conclusion OCT4 expression is related to metastasis and chemoresistance in lung adenocarcinoma patients, and thus indicates poor prognosis.http://dx.doi.org/10.3779/j.issn.1009-3419.2013.04.05Lung neoplasmsOCT4Prognosis |
| spellingShingle | Xueyan ZHANG Huimin WANG Bo JIN Qianggang DONG Jinsu HUANG Baohui HAN Correlations between OCT4 Expression and Clinicopathological Factors and Prognosis of Patients with Lung Adenocarcinoma Chinese Journal of Lung Cancer Lung neoplasms OCT4 Prognosis |
| title | Correlations between OCT4 Expression and Clinicopathological Factors
and Prognosis of Patients with Lung Adenocarcinoma |
| title_full | Correlations between OCT4 Expression and Clinicopathological Factors
and Prognosis of Patients with Lung Adenocarcinoma |
| title_fullStr | Correlations between OCT4 Expression and Clinicopathological Factors
and Prognosis of Patients with Lung Adenocarcinoma |
| title_full_unstemmed | Correlations between OCT4 Expression and Clinicopathological Factors
and Prognosis of Patients with Lung Adenocarcinoma |
| title_short | Correlations between OCT4 Expression and Clinicopathological Factors
and Prognosis of Patients with Lung Adenocarcinoma |
| title_sort | correlations between oct4 expression and clinicopathological factors
and prognosis of patients with lung adenocarcinoma |
| topic | Lung neoplasms OCT4 Prognosis |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2013.04.05 |
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