Polymorphism in COX-2 modifies the inverse association between <it>Helicobacter pylori </it>seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study
<p>Abstract</p> <p>Background</p> <p>Overexpression of Cyclooxygenase-2 (COX-2) was observed in many types of cancers, including esophageal squamous cell carcinoma (ESCC). One functional SNP, COX-2 -1195G/A, has been reported to mediate susceptibility of ESCC in Chinese...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-05-01
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| Series: | BMC Gastroenterology |
| Online Access: | http://www.biomedcentral.com/1471-230X/9/37 |
| _version_ | 1818050007104749568 |
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| author | Lee Jang-Ming Lee Ka-Wo Wu I-Chen Lee Chien-Hung Kuo Chao-Hung Hu Huang-Ming Goan Yih-Gang Chou Shah-Hwa Kao Ein-Long Wu Ming-Tsang Wu Deng-Chyang |
| author_facet | Lee Jang-Ming Lee Ka-Wo Wu I-Chen Lee Chien-Hung Kuo Chao-Hung Hu Huang-Ming Goan Yih-Gang Chou Shah-Hwa Kao Ein-Long Wu Ming-Tsang Wu Deng-Chyang |
| author_sort | Lee Jang-Ming |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Overexpression of Cyclooxygenase-2 (COX-2) was observed in many types of cancers, including esophageal squamous cell carcinoma (ESCC). One functional SNP, COX-2 -1195G/A, has been reported to mediate susceptibility of ESCC in Chinese populations. In our previous study, the presence of <it>Helicobacter pylori </it>(<it>H. pylori</it>) was found to play a protective role in development of ESCC. The interaction of COX-2 and <it>H. pylori </it>in gastric cancer was well investigated. However, literature on their interaction in ESCC risk is scarce. The purpose of this study was to evaluate the association and interaction between COX-2 single nucleotide polymorphism (SNP), <it>H. pylori </it>infection and the risk of developing ESCC.</p> <p>Methods</p> <p>One hundred and eighty patients with ESCC and 194 controls were enrolled in this study. Personal data regarding related risk factors, including alcohol consumption, smoking habits and betel quid chewing, were collected via questionnaire. Genotypes of the COX-2 -1195 polymorphism were determined by PCR-based restriction fragment length polymorphism. <it>H. pylori </it>seropositivity was defined by immunochromatographic screening test. Data was analyzed by chi-squared tests and polytomous logistics regression.</p> <p>Results</p> <p>In analysis adjusting for the covariates and confounders, <it>H. pylori </it>seropositivity was found to be inversely association with the ESCC development (adjusted OR: 0.5, 95% CI: 0.3 – 0.9). COX-2 -1195 AA homozygous was associated with an increased risk of contracting ESCC in comparison with the non-AA group, especially among patients with <it>H. pylori </it>seronegative (adjusted OR ratio: 2.9, 95% CI: 1.2 – 7.3). The effect was strengthened among patients with lower third ESCC (adjusted OR ratio: 6.9, 95% CI 2.1 – 22.5). Besides, <it>H. pylori </it>seropositivity conveyed a notably inverse effect among patients with COX-2 AA polymorphism (AOR ratio: 0.3, 95% CI: 0.1 – 0.9), and the effect was observed to be enhanced for the lower third ESCC patients (AOR ratio: 0.09, 95% CI: 0.02 – 0.47, <it>p </it>for multiplicative interaction 0.008)</p> <p>Conclusion</p> <p><it>H. pylori </it>seropositivity is inversely associated with the risk of ESCC in Taiwan, and COX-2 -1195 polymorphism plays a role in modifying the influence between <it>H. pylori </it>and ESCC, especially in lower third esophagus.</p> |
| first_indexed | 2024-12-10T10:46:37Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-12-10T10:46:37Z |
| publishDate | 2009-05-01 |
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| series | BMC Gastroenterology |
| spelling | doaj.art-dea451ecb5be48fe8fb8e3296eb58aa92022-12-22T01:52:09ZengBMCBMC Gastroenterology1471-230X2009-05-01913710.1186/1471-230X-9-37Polymorphism in COX-2 modifies the inverse association between <it>Helicobacter pylori </it>seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control studyLee Jang-MingLee Ka-WoWu I-ChenLee Chien-HungKuo Chao-HungHu Huang-MingGoan Yih-GangChou Shah-HwaKao Ein-LongWu Ming-TsangWu Deng-Chyang<p>Abstract</p> <p>Background</p> <p>Overexpression of Cyclooxygenase-2 (COX-2) was observed in many types of cancers, including esophageal squamous cell carcinoma (ESCC). One functional SNP, COX-2 -1195G/A, has been reported to mediate susceptibility of ESCC in Chinese populations. In our previous study, the presence of <it>Helicobacter pylori </it>(<it>H. pylori</it>) was found to play a protective role in development of ESCC. The interaction of COX-2 and <it>H. pylori </it>in gastric cancer was well investigated. However, literature on their interaction in ESCC risk is scarce. The purpose of this study was to evaluate the association and interaction between COX-2 single nucleotide polymorphism (SNP), <it>H. pylori </it>infection and the risk of developing ESCC.</p> <p>Methods</p> <p>One hundred and eighty patients with ESCC and 194 controls were enrolled in this study. Personal data regarding related risk factors, including alcohol consumption, smoking habits and betel quid chewing, were collected via questionnaire. Genotypes of the COX-2 -1195 polymorphism were determined by PCR-based restriction fragment length polymorphism. <it>H. pylori </it>seropositivity was defined by immunochromatographic screening test. Data was analyzed by chi-squared tests and polytomous logistics regression.</p> <p>Results</p> <p>In analysis adjusting for the covariates and confounders, <it>H. pylori </it>seropositivity was found to be inversely association with the ESCC development (adjusted OR: 0.5, 95% CI: 0.3 – 0.9). COX-2 -1195 AA homozygous was associated with an increased risk of contracting ESCC in comparison with the non-AA group, especially among patients with <it>H. pylori </it>seronegative (adjusted OR ratio: 2.9, 95% CI: 1.2 – 7.3). The effect was strengthened among patients with lower third ESCC (adjusted OR ratio: 6.9, 95% CI 2.1 – 22.5). Besides, <it>H. pylori </it>seropositivity conveyed a notably inverse effect among patients with COX-2 AA polymorphism (AOR ratio: 0.3, 95% CI: 0.1 – 0.9), and the effect was observed to be enhanced for the lower third ESCC patients (AOR ratio: 0.09, 95% CI: 0.02 – 0.47, <it>p </it>for multiplicative interaction 0.008)</p> <p>Conclusion</p> <p><it>H. pylori </it>seropositivity is inversely associated with the risk of ESCC in Taiwan, and COX-2 -1195 polymorphism plays a role in modifying the influence between <it>H. pylori </it>and ESCC, especially in lower third esophagus.</p>http://www.biomedcentral.com/1471-230X/9/37 |
| spellingShingle | Lee Jang-Ming Lee Ka-Wo Wu I-Chen Lee Chien-Hung Kuo Chao-Hung Hu Huang-Ming Goan Yih-Gang Chou Shah-Hwa Kao Ein-Long Wu Ming-Tsang Wu Deng-Chyang Polymorphism in COX-2 modifies the inverse association between <it>Helicobacter pylori </it>seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study BMC Gastroenterology |
| title | Polymorphism in COX-2 modifies the inverse association between <it>Helicobacter pylori </it>seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study |
| title_full | Polymorphism in COX-2 modifies the inverse association between <it>Helicobacter pylori </it>seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study |
| title_fullStr | Polymorphism in COX-2 modifies the inverse association between <it>Helicobacter pylori </it>seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study |
| title_full_unstemmed | Polymorphism in COX-2 modifies the inverse association between <it>Helicobacter pylori </it>seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study |
| title_short | Polymorphism in COX-2 modifies the inverse association between <it>Helicobacter pylori </it>seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study |
| title_sort | polymorphism in cox 2 modifies the inverse association between it helicobacter pylori it seropositivity and esophageal squamous cell carcinoma risk in taiwan a case control study |
| url | http://www.biomedcentral.com/1471-230X/9/37 |
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