The Circulating Level of Klotho Is Not Dependent upon Physical Fitness and Age-Associated Methylation Increases at the Promoter Region of the Klotho Gene

The Circulating Level of Klotho Is Not Dependent upon Physical Fitness and Age-Associated Methylation Increases at the Promoter Region of the Klotho Gene

(1) Background: Higher levels of physical fitness are believed to increase the physiological quality of life and impact the aging process with a wide range of adaptive mechanisms, including the regulation of the expression of the age-associated klotho (KL) gene and protein levels. (2) Methods: Here,...

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Bibliographic Details
Main Authors: Dora Aczel, Ferenc Torma, Matyas Jokai, Kristen McGreevy, Anita Boros, Yasuhiro Seki, Istvan Boldogh, Steve Horvath, Zsolt Radak
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Genes
Subjects:
aging
klotho
methylation
epigenetic clock
physical fitness
Online Access:https://www.mdpi.com/2073-4425/14/2/525

Internet

https://www.mdpi.com/2073-4425/14/2/525

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