Effects of natural polyphenol-rich pomegranate juice on the acute and delayed response of Homocysteine and steroidal hormones following weightlifting exercises: a double-blind, placebo-controlled trial
Background Maximal strength-speed exercise is a powerful stimulus to acutely increase concentrations of circulating steroid hormones and homocysteine [Hcy]. There is some evidence that antioxidant beverages rich in polyphenols can attenuate [Hcy] levels and modulate endocrine responses in favor of a...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-03-01
|
| Series: | Journal of the International Society of Sports Nutrition |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1186/s12970-020-00345-w |
| _version_ | 1797684974815543296 |
|---|---|
| author | Achraf Ammar MounaTurki Khaled Trabelsi Nicola Luigi Bragazzi Omar Boukhris Mohamed Bouaziz Fatma Ayadi Kais El Abed Tarak Driss Nizar Souissi Hamdi Chtourou Stephen J. Bailey Anita Hoekelmann |
| author_facet | Achraf Ammar MounaTurki Khaled Trabelsi Nicola Luigi Bragazzi Omar Boukhris Mohamed Bouaziz Fatma Ayadi Kais El Abed Tarak Driss Nizar Souissi Hamdi Chtourou Stephen J. Bailey Anita Hoekelmann |
| author_sort | Achraf Ammar |
| collection | DOAJ |
| description | Background Maximal strength-speed exercise is a powerful stimulus to acutely increase concentrations of circulating steroid hormones and homocysteine [Hcy]. There is some evidence that antioxidant beverages rich in polyphenols can attenuate [Hcy] levels and modulate endocrine responses in favor of an anabolic environment. Polyphenols-rich pomegranate (POM) have been reported to possess one of the highest antioxidant capacities compared to other purported nutraceuticals and other food stuffs. Studies focused on proving the beneficial effect of POM consumption during maximal strength exercises have only measured physical performance, muscle damage, oxidative stress and inflammatory responses, while POM effects on [Hcy] and hormonal adaptations are lacking. The aim of the present study was to investigate the effect of consuming natural polyphenol-rich pomegranate juice (POMj) on the acute and delayed [Hcy] and steroidal hormonal responses to a weightlifting exercises session. Methods Nine elite weightlifters (21.0 ± 1 years) performed two Olympic-weightlifting sessions after ingesting either the placebo (PLA) or POMj supplements. Venous blood samples were collected at rest and 3 min and 48 h after each session. Results Compared to baseline values, circulating cortisol [C] decreased (p < 0.01) and testosterone/cortisol [T/C] ratio increased immediately following the training session in both PLA and POMj conditions (p = 0.003 for PLA and p = 0.02 for POM). During the 48 h recovery period, all tested parameters were shown to recover to baseline values in both conditions with significant increases in [C] and decreases in [T/C] (p < 0.01 for PLA and p < 0.05 for POMj) from 3 min to 48 h post-exercises. Compared to PLA, a lower level of plasma testosterone [T] was registered 3 min post exercise using POMj supplementation (p = 0.012) and a significant decrease (p = 0.04, %change = − 14%) in plasma [Hcy] was registered during the 48 h recovery period only using POMj. A moderate correlation was observed between [Hcy] and [T] responses (p = 0.002, r = − 0.50). Conclusion In conclusion, supplementation with POMj has the potential to attenuate the acute plasma [T] response, but did not effect 48 h recovery kinetics of [Hcy] following weightlifting exercise. Further studies investigating androgen levels in both plasma and muscular tissue are needed to resolve the functional consequences of the observed acute POMj effect on plasma [T]. Trial registration Clinical Trials.gov, ID: NCT02697903. Registered 03 March 2016. |
| first_indexed | 2024-03-12T00:38:40Z |
| format | Article |
| id | doaj.art-dea73e1317894658bc5403be691572c1 |
| institution | Directory Open Access Journal |
| issn | 1550-2783 |
| language | English |
| last_indexed | 2024-03-12T00:38:40Z |
| publishDate | 2020-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of the International Society of Sports Nutrition |
| spelling | doaj.art-dea73e1317894658bc5403be691572c12023-09-15T09:19:31ZengTaylor & Francis GroupJournal of the International Society of Sports Nutrition1550-27832020-03-0117110.1186/s12970-020-00345-w12130155Effects of natural polyphenol-rich pomegranate juice on the acute and delayed response of Homocysteine and steroidal hormones following weightlifting exercises: a double-blind, placebo-controlled trialAchraf Ammar0MounaTurki1Khaled Trabelsi2Nicola Luigi Bragazzi3Omar Boukhris4Mohamed Bouaziz5Fatma Ayadi6Kais El Abed7Tarak Driss8Nizar Souissi9Hamdi Chtourou10Stephen J. Bailey11Anita Hoekelmann12Institute of Sport SciencesLaboratory of Biochemistry, CHU Habib BourguibaHigh Institute of Sport and Physical EducationDepartment of Health Sciences (DISSAL), Postgraduate School of Public HealthHigh Institute of Sport and Physical EducationHigh Institute of BiotechnologyLaboratory of Biochemistry, CHU Habib BourguibaHigh Institute of Sport and Physical EducationInterdisciplinary Laboratory in Neurosciences, Physiology and Psychology: Physical Activity, Health and Learning (LINP2-2APS), UFR STAPS, UPLActivité Physique, Sport et Santé, UR18JS01, Observatoire National du SportHigh Institute of Sport and Physical EducationSchool of Sport, Exercise and Health SciencesInstitute of Sport SciencesBackground Maximal strength-speed exercise is a powerful stimulus to acutely increase concentrations of circulating steroid hormones and homocysteine [Hcy]. There is some evidence that antioxidant beverages rich in polyphenols can attenuate [Hcy] levels and modulate endocrine responses in favor of an anabolic environment. Polyphenols-rich pomegranate (POM) have been reported to possess one of the highest antioxidant capacities compared to other purported nutraceuticals and other food stuffs. Studies focused on proving the beneficial effect of POM consumption during maximal strength exercises have only measured physical performance, muscle damage, oxidative stress and inflammatory responses, while POM effects on [Hcy] and hormonal adaptations are lacking. The aim of the present study was to investigate the effect of consuming natural polyphenol-rich pomegranate juice (POMj) on the acute and delayed [Hcy] and steroidal hormonal responses to a weightlifting exercises session. Methods Nine elite weightlifters (21.0 ± 1 years) performed two Olympic-weightlifting sessions after ingesting either the placebo (PLA) or POMj supplements. Venous blood samples were collected at rest and 3 min and 48 h after each session. Results Compared to baseline values, circulating cortisol [C] decreased (p < 0.01) and testosterone/cortisol [T/C] ratio increased immediately following the training session in both PLA and POMj conditions (p = 0.003 for PLA and p = 0.02 for POM). During the 48 h recovery period, all tested parameters were shown to recover to baseline values in both conditions with significant increases in [C] and decreases in [T/C] (p < 0.01 for PLA and p < 0.05 for POMj) from 3 min to 48 h post-exercises. Compared to PLA, a lower level of plasma testosterone [T] was registered 3 min post exercise using POMj supplementation (p = 0.012) and a significant decrease (p = 0.04, %change = − 14%) in plasma [Hcy] was registered during the 48 h recovery period only using POMj. A moderate correlation was observed between [Hcy] and [T] responses (p = 0.002, r = − 0.50). Conclusion In conclusion, supplementation with POMj has the potential to attenuate the acute plasma [T] response, but did not effect 48 h recovery kinetics of [Hcy] following weightlifting exercise. Further studies investigating androgen levels in both plasma and muscular tissue are needed to resolve the functional consequences of the observed acute POMj effect on plasma [T]. Trial registration Clinical Trials.gov, ID: NCT02697903. Registered 03 March 2016.http://dx.doi.org/10.1186/s12970-020-00345-wsupplementationtestosteronecortisolcardio-vascular healthantioxidantstrength |
| spellingShingle | Achraf Ammar MounaTurki Khaled Trabelsi Nicola Luigi Bragazzi Omar Boukhris Mohamed Bouaziz Fatma Ayadi Kais El Abed Tarak Driss Nizar Souissi Hamdi Chtourou Stephen J. Bailey Anita Hoekelmann Effects of natural polyphenol-rich pomegranate juice on the acute and delayed response of Homocysteine and steroidal hormones following weightlifting exercises: a double-blind, placebo-controlled trial Journal of the International Society of Sports Nutrition supplementation testosterone cortisol cardio-vascular health antioxidant strength |
| title | Effects of natural polyphenol-rich pomegranate juice on the acute and delayed response of Homocysteine and steroidal hormones following weightlifting exercises: a double-blind, placebo-controlled trial |
| title_full | Effects of natural polyphenol-rich pomegranate juice on the acute and delayed response of Homocysteine and steroidal hormones following weightlifting exercises: a double-blind, placebo-controlled trial |
| title_fullStr | Effects of natural polyphenol-rich pomegranate juice on the acute and delayed response of Homocysteine and steroidal hormones following weightlifting exercises: a double-blind, placebo-controlled trial |
| title_full_unstemmed | Effects of natural polyphenol-rich pomegranate juice on the acute and delayed response of Homocysteine and steroidal hormones following weightlifting exercises: a double-blind, placebo-controlled trial |
| title_short | Effects of natural polyphenol-rich pomegranate juice on the acute and delayed response of Homocysteine and steroidal hormones following weightlifting exercises: a double-blind, placebo-controlled trial |
| title_sort | effects of natural polyphenol rich pomegranate juice on the acute and delayed response of homocysteine and steroidal hormones following weightlifting exercises a double blind placebo controlled trial |
| topic | supplementation testosterone cortisol cardio-vascular health antioxidant strength |
| url | http://dx.doi.org/10.1186/s12970-020-00345-w |
| work_keys_str_mv | AT achrafammar effectsofnaturalpolyphenolrichpomegranatejuiceontheacuteanddelayedresponseofhomocysteineandsteroidalhormonesfollowingweightliftingexercisesadoubleblindplacebocontrolledtrial AT mounaturki effectsofnaturalpolyphenolrichpomegranatejuiceontheacuteanddelayedresponseofhomocysteineandsteroidalhormonesfollowingweightliftingexercisesadoubleblindplacebocontrolledtrial AT khaledtrabelsi effectsofnaturalpolyphenolrichpomegranatejuiceontheacuteanddelayedresponseofhomocysteineandsteroidalhormonesfollowingweightliftingexercisesadoubleblindplacebocontrolledtrial AT nicolaluigibragazzi effectsofnaturalpolyphenolrichpomegranatejuiceontheacuteanddelayedresponseofhomocysteineandsteroidalhormonesfollowingweightliftingexercisesadoubleblindplacebocontrolledtrial AT omarboukhris effectsofnaturalpolyphenolrichpomegranatejuiceontheacuteanddelayedresponseofhomocysteineandsteroidalhormonesfollowingweightliftingexercisesadoubleblindplacebocontrolledtrial AT mohamedbouaziz effectsofnaturalpolyphenolrichpomegranatejuiceontheacuteanddelayedresponseofhomocysteineandsteroidalhormonesfollowingweightliftingexercisesadoubleblindplacebocontrolledtrial AT fatmaayadi effectsofnaturalpolyphenolrichpomegranatejuiceontheacuteanddelayedresponseofhomocysteineandsteroidalhormonesfollowingweightliftingexercisesadoubleblindplacebocontrolledtrial AT kaiselabed effectsofnaturalpolyphenolrichpomegranatejuiceontheacuteanddelayedresponseofhomocysteineandsteroidalhormonesfollowingweightliftingexercisesadoubleblindplacebocontrolledtrial AT tarakdriss effectsofnaturalpolyphenolrichpomegranatejuiceontheacuteanddelayedresponseofhomocysteineandsteroidalhormonesfollowingweightliftingexercisesadoubleblindplacebocontrolledtrial AT nizarsouissi effectsofnaturalpolyphenolrichpomegranatejuiceontheacuteanddelayedresponseofhomocysteineandsteroidalhormonesfollowingweightliftingexercisesadoubleblindplacebocontrolledtrial AT hamdichtourou effectsofnaturalpolyphenolrichpomegranatejuiceontheacuteanddelayedresponseofhomocysteineandsteroidalhormonesfollowingweightliftingexercisesadoubleblindplacebocontrolledtrial AT stephenjbailey effectsofnaturalpolyphenolrichpomegranatejuiceontheacuteanddelayedresponseofhomocysteineandsteroidalhormonesfollowingweightliftingexercisesadoubleblindplacebocontrolledtrial AT anitahoekelmann effectsofnaturalpolyphenolrichpomegranatejuiceontheacuteanddelayedresponseofhomocysteineandsteroidalhormonesfollowingweightliftingexercisesadoubleblindplacebocontrolledtrial |