Association of LINC00673 Genetic Variants with Progression of Oral Cancer
Oral squamous cell carcinoma (OSCC) is a multifactorial malignancy, and its high incidence and mortality rate remain a global public health burden. Polymorphisms in the long intergenic noncoding RNA 673 (<i>LINC00673</i>) have been currently connected to the predisposition to various can...
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MDPI AG
2021-05-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/6/468 |
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| author | Shih-Chi Su Chiao-Wen Lin Po-Chung Ju Lun-Ching Chang Chun-Yi Chuang Yu-Fan Liu Ming-Ju Hsieh Shun-Fa Yang |
| author_facet | Shih-Chi Su Chiao-Wen Lin Po-Chung Ju Lun-Ching Chang Chun-Yi Chuang Yu-Fan Liu Ming-Ju Hsieh Shun-Fa Yang |
| author_sort | Shih-Chi Su |
| collection | DOAJ |
| description | Oral squamous cell carcinoma (OSCC) is a multifactorial malignancy, and its high incidence and mortality rate remain a global public health burden. Polymorphisms in the long intergenic noncoding RNA 673 (<i>LINC00673</i>) have been currently connected to the predisposition to various cancer types. The present study attempted to explore the impact of <i>LINC00673</i> gene polymorphisms on the risk and progression of OSCC. Three <i>LINC00673</i> single-nucleotide polymorphisms (SNPs), including rs11655237, rs9914618, and rs6501551, were evaluated in 1231 OSCCC cases and 1194 cancer-free controls. We did not observe any significant association of three individual SNPs with the risk of OSCC between the case and control group. However, while assessing the clinicopathological parameters, patients carrying at least one minor allele of rs9914618 (GA and AA; OR, 1.286; 95% CI, 1.008–1.642; <i>p</i> = 0.043) were found to develop lymph node metastasis more often compared to those who are homozygous for the major allele. Further stratification analyses revealed that this genetic correlation with increased risk of lymphatic spread was further fortified in habitual betel quid chewers (OR, 1.534; 95% CI, 1.160–2.028; <i>p</i> = 0.003) or smokers (OR, 1.320; 95% CI, 1.013–1.721; <i>p</i> = 0.040). Moreover, through analyzing the dataset from The Cancer Genome Atlas (TCGA), we found that elevated <i>LINC00673</i> levels were associated with the development of large tumors in patients with head and neck squamous cell carcinoma and the risk of lymphatic spread in smokers. These data demonstrate a joint effect of <i>LINC00673</i> rs9914618 with betel nut chewing or smoking on the progression of oral cancer. |
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| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T11:03:55Z |
| publishDate | 2021-05-01 |
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| spelling | doaj.art-dea9543a49e64bc585c714a58223d1642023-11-21T21:19:03ZengMDPI AGJournal of Personalized Medicine2075-44262021-05-0111646810.3390/jpm11060468Association of LINC00673 Genetic Variants with Progression of Oral CancerShih-Chi Su0Chiao-Wen Lin1Po-Chung Ju2Lun-Ching Chang3Chun-Yi Chuang4Yu-Fan Liu5Ming-Ju Hsieh6Shun-Fa Yang7Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung 204, TaiwanInstitute of Oral Sciences, Chung Shan Medical University, Taichung 402, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung 402, TaiwanDepartment of Mathematical Sciences, Florida Atlantic University, Boca Raton, FL 33431, USASchool of Medicine, Chung Shan Medical University, Taichung 402, TaiwanDepartment of Biomedical Sciences, Chung Shan Medical University, Taichung 402, TaiwanOral Cancer Research Center, Changhua Christian Hospital, Changhua 500, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanOral squamous cell carcinoma (OSCC) is a multifactorial malignancy, and its high incidence and mortality rate remain a global public health burden. Polymorphisms in the long intergenic noncoding RNA 673 (<i>LINC00673</i>) have been currently connected to the predisposition to various cancer types. The present study attempted to explore the impact of <i>LINC00673</i> gene polymorphisms on the risk and progression of OSCC. Three <i>LINC00673</i> single-nucleotide polymorphisms (SNPs), including rs11655237, rs9914618, and rs6501551, were evaluated in 1231 OSCCC cases and 1194 cancer-free controls. We did not observe any significant association of three individual SNPs with the risk of OSCC between the case and control group. However, while assessing the clinicopathological parameters, patients carrying at least one minor allele of rs9914618 (GA and AA; OR, 1.286; 95% CI, 1.008–1.642; <i>p</i> = 0.043) were found to develop lymph node metastasis more often compared to those who are homozygous for the major allele. Further stratification analyses revealed that this genetic correlation with increased risk of lymphatic spread was further fortified in habitual betel quid chewers (OR, 1.534; 95% CI, 1.160–2.028; <i>p</i> = 0.003) or smokers (OR, 1.320; 95% CI, 1.013–1.721; <i>p</i> = 0.040). Moreover, through analyzing the dataset from The Cancer Genome Atlas (TCGA), we found that elevated <i>LINC00673</i> levels were associated with the development of large tumors in patients with head and neck squamous cell carcinoma and the risk of lymphatic spread in smokers. These data demonstrate a joint effect of <i>LINC00673</i> rs9914618 with betel nut chewing or smoking on the progression of oral cancer.https://www.mdpi.com/2075-4426/11/6/468oral squamous cell carcinomalong noncoding RNAsingle-nucleotide polymorphismlymph node metastasis |
| spellingShingle | Shih-Chi Su Chiao-Wen Lin Po-Chung Ju Lun-Ching Chang Chun-Yi Chuang Yu-Fan Liu Ming-Ju Hsieh Shun-Fa Yang Association of LINC00673 Genetic Variants with Progression of Oral Cancer Journal of Personalized Medicine oral squamous cell carcinoma long noncoding RNA single-nucleotide polymorphism lymph node metastasis |
| title | Association of LINC00673 Genetic Variants with Progression of Oral Cancer |
| title_full | Association of LINC00673 Genetic Variants with Progression of Oral Cancer |
| title_fullStr | Association of LINC00673 Genetic Variants with Progression of Oral Cancer |
| title_full_unstemmed | Association of LINC00673 Genetic Variants with Progression of Oral Cancer |
| title_short | Association of LINC00673 Genetic Variants with Progression of Oral Cancer |
| title_sort | association of linc00673 genetic variants with progression of oral cancer |
| topic | oral squamous cell carcinoma long noncoding RNA single-nucleotide polymorphism lymph node metastasis |
| url | https://www.mdpi.com/2075-4426/11/6/468 |
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