Comparative Evaluation of Clinical, Spiro/Oscillometric and Tomographic Parameters as a Global Assessment of Children with Cystic Fibrosis
Aim:The aim of our study was to compare clinical severity scores and classic spirometry with impulse oscillometry (IOS) results and thoracic high resolution computed tomography (HRCT) scores in children with cystic fibrosis (CF) in order to determine the utility of the latter approach in patient fol...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2023-03-01
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| Series: | Journal of Pediatric Research |
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http://jpedres.org/archives/archive-detail/article-preview/comparative-evaluation-of-clinical-spiro-oscillome/58762
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| author | Esra Toprak Kanık Özge Yılmaz Ali Kanık Emine Ece Özdoğru Yurda Şimşek Hüseyin Hüdaver Alper Hasan Yüksel |
| author_facet | Esra Toprak Kanık Özge Yılmaz Ali Kanık Emine Ece Özdoğru Yurda Şimşek Hüseyin Hüdaver Alper Hasan Yüksel |
| author_sort | Esra Toprak Kanık |
| collection | DOAJ |
| description | Aim:The aim of our study was to compare clinical severity scores and classic spirometry with impulse oscillometry (IOS) results and thoracic high resolution computed tomography (HRCT) scores in children with cystic fibrosis (CF) in order to determine the utility of the latter approach in patient follow-up.Materials and Methods:CF patients over 6 years of age were included. Shwachman-Kulczycki score, underclassical spirometry and IOS were performed when not in acute exacerbation. Thoracic HRCT images obtained within the previous 6 months were evaluated using the Bhalla scoring system.Results:The mean age of the children studied (n=30) was 12.1±4.2 years and 40% were female. Pseudomonas aeruginosa (P. aeroginosa) was isolated from sputum cultures of 40% of the patients. Patients with forced expiratory volume in one second (FEV1) below 80% exhibited significantly higher (resistance) R5, R10 values and significantly lower (reactance) X5 values on IOS (p=0.03, 0.027, 0.006, respectively). Patients with P. aeruginosa had significantly lower FEV1, forced vital capacity, and forced expiratory flow (25-75) values in classic spirometry when compared with patients without P. aeruginosa (p=0.002, p=0.002, and p=0.005, respectively). P. aeruginosa-positive patients showed significantly higher R5 and lower X5 values (p=0.047, 0.046, respectively). Bhalla scoring, bronchiectasis weight, peribronchial thickening, mucous plaques, saccularization, bronchial division, mosaic pattern parameters in groups with P. aeroginosa growth and/or FEV1 <80%; was found to be significantly more serious than the non-reproductive group (p<0.005, respectively). Again, in the group with P. aeroginosa growth, Shwachman-Kulczycki score was found to be significantly lower (p=0.001). No significant correlation was found between thoracic score data such as bronchiectasis weight and mosaic pattern presence and IOS values. In addition, in the group with high clinical score of Shwachman Kulczycki, resistance values such as R5 R10 R15 which are IOS parameters, and FEV1 were found above 80% (p=0.016, p=0.037, p=0.042, 0.004, respectively).Conclusion:IOS and tomographic scoring can be used safely in early detection of impairment in lung function. Further studies are needed to evaluate the utility of IOS in the clinical monitoring of children with CF who are not compliant with spirometry maneuvers. |
| first_indexed | 2024-04-10T06:15:37Z |
| format | Article |
| id | doaj.art-dea982b65dd147729639909d7c2b31be |
| institution | Directory Open Access Journal |
| issn | 2147-9445 2587-2478 |
| language | English |
| last_indexed | 2024-04-10T06:15:37Z |
| publishDate | 2023-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Pediatric Research |
| spelling | doaj.art-dea982b65dd147729639909d7c2b31be2023-03-02T08:20:57ZengGalenos YayineviJournal of Pediatric Research2147-94452587-24782023-03-01101344210.4274/jpr.galenos.2022.0958213049054Comparative Evaluation of Clinical, Spiro/Oscillometric and Tomographic Parameters as a Global Assessment of Children with Cystic FibrosisEsra Toprak Kanık0Özge Yılmaz1Ali Kanık2Emine Ece Özdoğru3Yurda Şimşek4Hüseyin Hüdaver Alper5Hasan Yüksel6 Manisa Celal Bayar University Faculty of Medicine, Department of Pediatric Allergy and Pulmonology, Manisa, Turkey Manisa Celal Bayar University Faculty of Medicine, Department of Pediatric Allergy and Pulmonology, Manisa, Turkey İzmir Katip Çelebi University Faculty of Medicine, Department of Pediatrics, İzmir, Turkey University of Health Sciences Turkey, İzmir Tepecik Training and Research Hospital, Clinic of Pediatric Allergy, İzmir, Turkey Manisa Celal Bayar University Faculty of Medicine, Department of Pediatric Allergy and Pulmonology, Manisa, Turkey Ege University Faculty of Medicine, Department of Radiology, İzmir, Turkey Manisa Celal Bayar University Faculty of Medicine, Department of Pediatric Allergy and Pulmonology, Manisa, Turkey Aim:The aim of our study was to compare clinical severity scores and classic spirometry with impulse oscillometry (IOS) results and thoracic high resolution computed tomography (HRCT) scores in children with cystic fibrosis (CF) in order to determine the utility of the latter approach in patient follow-up.Materials and Methods:CF patients over 6 years of age were included. Shwachman-Kulczycki score, underclassical spirometry and IOS were performed when not in acute exacerbation. Thoracic HRCT images obtained within the previous 6 months were evaluated using the Bhalla scoring system.Results:The mean age of the children studied (n=30) was 12.1±4.2 years and 40% were female. Pseudomonas aeruginosa (P. aeroginosa) was isolated from sputum cultures of 40% of the patients. Patients with forced expiratory volume in one second (FEV1) below 80% exhibited significantly higher (resistance) R5, R10 values and significantly lower (reactance) X5 values on IOS (p=0.03, 0.027, 0.006, respectively). Patients with P. aeruginosa had significantly lower FEV1, forced vital capacity, and forced expiratory flow (25-75) values in classic spirometry when compared with patients without P. aeruginosa (p=0.002, p=0.002, and p=0.005, respectively). P. aeruginosa-positive patients showed significantly higher R5 and lower X5 values (p=0.047, 0.046, respectively). Bhalla scoring, bronchiectasis weight, peribronchial thickening, mucous plaques, saccularization, bronchial division, mosaic pattern parameters in groups with P. aeroginosa growth and/or FEV1 <80%; was found to be significantly more serious than the non-reproductive group (p<0.005, respectively). Again, in the group with P. aeroginosa growth, Shwachman-Kulczycki score was found to be significantly lower (p=0.001). No significant correlation was found between thoracic score data such as bronchiectasis weight and mosaic pattern presence and IOS values. In addition, in the group with high clinical score of Shwachman Kulczycki, resistance values such as R5 R10 R15 which are IOS parameters, and FEV1 were found above 80% (p=0.016, p=0.037, p=0.042, 0.004, respectively).Conclusion:IOS and tomographic scoring can be used safely in early detection of impairment in lung function. Further studies are needed to evaluate the utility of IOS in the clinical monitoring of children with CF who are not compliant with spirometry maneuvers. http://jpedres.org/archives/archive-detail/article-preview/comparative-evaluation-of-clinical-spiro-oscillome/58762 bhallacystic fibrosisspirometryimpulse oscillometrythoracic hrct |
| spellingShingle | Esra Toprak Kanık Özge Yılmaz Ali Kanık Emine Ece Özdoğru Yurda Şimşek Hüseyin Hüdaver Alper Hasan Yüksel Comparative Evaluation of Clinical, Spiro/Oscillometric and Tomographic Parameters as a Global Assessment of Children with Cystic Fibrosis Journal of Pediatric Research bhalla cystic fibrosis spirometry impulse oscillometry thoracic hrct |
| title | Comparative Evaluation of Clinical, Spiro/Oscillometric and Tomographic Parameters as a Global Assessment of Children with Cystic Fibrosis |
| title_full | Comparative Evaluation of Clinical, Spiro/Oscillometric and Tomographic Parameters as a Global Assessment of Children with Cystic Fibrosis |
| title_fullStr | Comparative Evaluation of Clinical, Spiro/Oscillometric and Tomographic Parameters as a Global Assessment of Children with Cystic Fibrosis |
| title_full_unstemmed | Comparative Evaluation of Clinical, Spiro/Oscillometric and Tomographic Parameters as a Global Assessment of Children with Cystic Fibrosis |
| title_short | Comparative Evaluation of Clinical, Spiro/Oscillometric and Tomographic Parameters as a Global Assessment of Children with Cystic Fibrosis |
| title_sort | comparative evaluation of clinical spiro oscillometric and tomographic parameters as a global assessment of children with cystic fibrosis |
| topic | bhalla cystic fibrosis spirometry impulse oscillometry thoracic hrct |
| url |
http://jpedres.org/archives/archive-detail/article-preview/comparative-evaluation-of-clinical-spiro-oscillome/58762
|
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