Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch
Short-lived RNA folding intermediates have important roles in the folding of RNA. Here, the authors combine 15N relaxation dispersion NMR with chemical probing to visualise one of these intermediates, and are able to show it is a secondary structural switch, that might help with folding.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11768 |
| _version_ | 1818991309699940352 |
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| author | Yi Xue Brant Gracia Daniel Herschlag Rick Russell Hashim M. Al-Hashimi |
| author_facet | Yi Xue Brant Gracia Daniel Herschlag Rick Russell Hashim M. Al-Hashimi |
| author_sort | Yi Xue |
| collection | DOAJ |
| description | Short-lived RNA folding intermediates have important roles in the folding of RNA. Here, the authors combine 15N relaxation dispersion NMR with chemical probing to visualise one of these intermediates, and are able to show it is a secondary structural switch, that might help with folding. |
| first_indexed | 2024-12-20T20:08:13Z |
| format | Article |
| id | doaj.art-deaa5227c7d8451dba01c449d0c89643 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:08:13Z |
| publishDate | 2016-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-deaa5227c7d8451dba01c449d0c896432022-12-21T19:27:54ZengNature PortfolioNature Communications2041-17232016-06-017111110.1038/ncomms11768Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switchYi Xue0Brant Gracia1Daniel Herschlag2Rick Russell3Hashim M. Al-Hashimi4Department of Biochemistry, Duke Center for RNA Biology, Duke University Medical CenterDepartment of Molecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at AustinDepartment of Biochemistry, Beckman Center, Stanford UniversityDepartment of Molecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at AustinDepartment of Biochemistry, Duke Center for RNA Biology, Duke University Medical CenterShort-lived RNA folding intermediates have important roles in the folding of RNA. Here, the authors combine 15N relaxation dispersion NMR with chemical probing to visualise one of these intermediates, and are able to show it is a secondary structural switch, that might help with folding.https://doi.org/10.1038/ncomms11768 |
| spellingShingle | Yi Xue Brant Gracia Daniel Herschlag Rick Russell Hashim M. Al-Hashimi Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch Nature Communications |
| title | Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch |
| title_full | Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch |
| title_fullStr | Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch |
| title_full_unstemmed | Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch |
| title_short | Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch |
| title_sort | visualizing the formation of an rna folding intermediate through a fast highly modular secondary structure switch |
| url | https://doi.org/10.1038/ncomms11768 |
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