Analysis of coronary artery lesion degree and related risk factors in patients with coronary heart disease
Background. The study of the association of risk factors and atherosclerotic burden assessed by coronary angiography is promising in terms of both understanding the pathogenesis of the disease and predicting its development. The aim of the study was to investigate the relationship between traditiona...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2023-05-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/4073 |
| _version_ | 1797237165460029440 |
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| author | O. V. Atamas M. V. Antonyuk |
| author_facet | O. V. Atamas M. V. Antonyuk |
| author_sort | O. V. Atamas |
| collection | DOAJ |
| description | Background. The study of the association of risk factors and atherosclerotic burden assessed by coronary angiography is promising in terms of both understanding the pathogenesis of the disease and predicting its development. The aim of the study was to investigate the relationship between traditional risk factors and the severity of coronary atherosclerosis in patients with stable CHD.Materials and methods. Risk factors were studied in 100 patients who underwent angiography. Based on the Gensini (GS) score, participants were divided into groups: patients with moderate lesion of coronary arteries (GS = 8–39), with severe lesion (GS ≥ 40), and control group (GS = 0). To verify the association between the variables, Pearson’s chi-square test was used. The results were presented as relative risk (RR) and the confidence interval (95% CI).Results. It was found that in patients with GS score less than 40 points, statistically significant factors were hypertension (RR = 2.6; 95% CI: 1.023–10.09; р = 0.018), family history (RR = 2.94; 95% CI: 1.501–5.762; р < 0.001), depression (RR = 1.81; 95% CI: 1.202–2.738; р = 0.028), In patients with GS ≥ 40, the most important factors were diabetes (RR = 1.72; 95% CI: 1.187–2.511; р = 0,017), family history (RR = 2.02; 95% CI: 1.233–3.315; р = 0.002), inactivity (RR = 1.85; 95% CI: 1.219–2.824; р = 0.005). The GS scores were significantly higher in smokers compared non-smokers (44.0 vs. 32.0; p = 0.043).Conclusion. The most significant influence on the development of coronary atherosclerosis is exerted by a family history and physical inactivity. Arterial hypertension and depression are associated with moderate coronary artery disease. Severe athero sclerosis is associated with diabetes mellitus, long smoking history, low levels of high-density lipoprotein cholesterol. |
| first_indexed | 2024-03-08T12:15:24Z |
| format | Article |
| id | doaj.art-deab8219bef947cc8c2950bd8e212d18 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:15:25Z |
| publishDate | 2023-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-deab8219bef947cc8c2950bd8e212d182024-03-28T07:49:28ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962023-05-01829310210.29413/ABS.2023-8.2.92531Analysis of coronary artery lesion degree and related risk factors in patients with coronary heart diseaseO. V. Atamas0M. V. Antonyuk1Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Institute of Medical Climatology and Rehabilitative Treatment; Far Eastern Federal University, Medical CenterVladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Institute of Medical Climatology and Rehabilitative TreatmentBackground. The study of the association of risk factors and atherosclerotic burden assessed by coronary angiography is promising in terms of both understanding the pathogenesis of the disease and predicting its development. The aim of the study was to investigate the relationship between traditional risk factors and the severity of coronary atherosclerosis in patients with stable CHD.Materials and methods. Risk factors were studied in 100 patients who underwent angiography. Based on the Gensini (GS) score, participants were divided into groups: patients with moderate lesion of coronary arteries (GS = 8–39), with severe lesion (GS ≥ 40), and control group (GS = 0). To verify the association between the variables, Pearson’s chi-square test was used. The results were presented as relative risk (RR) and the confidence interval (95% CI).Results. It was found that in patients with GS score less than 40 points, statistically significant factors were hypertension (RR = 2.6; 95% CI: 1.023–10.09; р = 0.018), family history (RR = 2.94; 95% CI: 1.501–5.762; р < 0.001), depression (RR = 1.81; 95% CI: 1.202–2.738; р = 0.028), In patients with GS ≥ 40, the most important factors were diabetes (RR = 1.72; 95% CI: 1.187–2.511; р = 0,017), family history (RR = 2.02; 95% CI: 1.233–3.315; р = 0.002), inactivity (RR = 1.85; 95% CI: 1.219–2.824; р = 0.005). The GS scores were significantly higher in smokers compared non-smokers (44.0 vs. 32.0; p = 0.043).Conclusion. The most significant influence on the development of coronary atherosclerosis is exerted by a family history and physical inactivity. Arterial hypertension and depression are associated with moderate coronary artery disease. Severe athero sclerosis is associated with diabetes mellitus, long smoking history, low levels of high-density lipoprotein cholesterol.https://www.actabiomedica.ru/jour/article/view/4073coronary heart diseasecoronarographygensini scorerisk factors |
| spellingShingle | O. V. Atamas M. V. Antonyuk Analysis of coronary artery lesion degree and related risk factors in patients with coronary heart disease Acta Biomedica Scientifica coronary heart disease coronarography gensini score risk factors |
| title | Analysis of coronary artery lesion degree and related risk factors in patients with coronary heart disease |
| title_full | Analysis of coronary artery lesion degree and related risk factors in patients with coronary heart disease |
| title_fullStr | Analysis of coronary artery lesion degree and related risk factors in patients with coronary heart disease |
| title_full_unstemmed | Analysis of coronary artery lesion degree and related risk factors in patients with coronary heart disease |
| title_short | Analysis of coronary artery lesion degree and related risk factors in patients with coronary heart disease |
| title_sort | analysis of coronary artery lesion degree and related risk factors in patients with coronary heart disease |
| topic | coronary heart disease coronarography gensini score risk factors |
| url | https://www.actabiomedica.ru/jour/article/view/4073 |
| work_keys_str_mv | AT ovatamas analysisofcoronaryarterylesiondegreeandrelatedriskfactorsinpatientswithcoronaryheartdisease AT mvantonyuk analysisofcoronaryarterylesiondegreeandrelatedriskfactorsinpatientswithcoronaryheartdisease |