Clinicopathologic and endoscopic features of early-stage colorectal serrated adenocarcinoma
Abstract Background Serrated adenocarcinoma (SAC) is a distinct colorectal carcinoma variant that accounts for approximately 7.5% of all advanced colorectal carcinomas. While its prognosis is worse than conventional carcinoma, its early-stage clinicopathologic features are unclear. We therefore aime...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | BMC Gastroenterology |
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| Online Access: | http://link.springer.com/article/10.1186/s12876-017-0702-x |
| _version_ | 1818342197460729856 |
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| author | Daiki Hirano Shiro Oka Shinji Tanaka Kyoku Sumimoto Yuki Ninomiya Yuzuru Tamaru Kenjiro Shigita Nana Hayashi Yuji Urabe Yasuhiko Kitadai Fumio Shimamoto Koji Arihiro Kazuaki Chayama |
| author_facet | Daiki Hirano Shiro Oka Shinji Tanaka Kyoku Sumimoto Yuki Ninomiya Yuzuru Tamaru Kenjiro Shigita Nana Hayashi Yuji Urabe Yasuhiko Kitadai Fumio Shimamoto Koji Arihiro Kazuaki Chayama |
| author_sort | Daiki Hirano |
| collection | DOAJ |
| description | Abstract Background Serrated adenocarcinoma (SAC) is a distinct colorectal carcinoma variant that accounts for approximately 7.5% of all advanced colorectal carcinomas. While its prognosis is worse than conventional carcinoma, its early-stage clinicopathologic features are unclear. We therefore aimed to clarify the clinicopathologic and endoscopic characteristics of early-stage SACs. Methods Forty consecutive early-stage SAC patients at Hiroshima University Hospital were enrolled; SACs were classified into epithelial serration (Group A, n = 17) and non-epithelial serration (Group B, n = 23) groups. Additionally, we classified serrated adenoma into 4 types: sessile serrated adenoma (SSA), traditional serrated adenoma (TSA), unclassified, and non-serrated adenoma type. Results There were significant differences between Groups A and B in terms of tumor size (27.6 vs. 43.1 mm), incidences of T1 carcinoma (71% vs. 13%), and having the same color as normal mucosa (47% vs. 17%), respectively (p <0.01). In SACs >20 mm, the incidence of T1 carcinoma in Group A (70%) was significantly greater than that in Group B (13%) (p <0.05). There were significant differences in ‘Japan NBI Expert Team’ type 3 and type V pit pattern classifications between the 2 groups. The average TSA-type tumor size (42.6 mm) was significantly larger than that of the SSA (17.2 mm) and non-serrated component types (18.3 mm). The incidences of submucosal invasion in SSA- (80%), unclassified- (100%), and non-serrated-type (100%) tumors were significantly higher than that in the TSA type (11%). Conclusions Epithelial serration in the cancerous area and a non-TSA background indicated aggressive behavior in early-stage SACs. |
| first_indexed | 2024-12-13T16:10:52Z |
| format | Article |
| id | doaj.art-deafd8dacc1443019f7df88f66a3a0fd |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-13T16:10:52Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-deafd8dacc1443019f7df88f66a3a0fd2022-12-21T23:38:56ZengBMCBMC Gastroenterology1471-230X2017-12-011711710.1186/s12876-017-0702-xClinicopathologic and endoscopic features of early-stage colorectal serrated adenocarcinomaDaiki Hirano0Shiro Oka1Shinji Tanaka2Kyoku Sumimoto3Yuki Ninomiya4Yuzuru Tamaru5Kenjiro Shigita6Nana Hayashi7Yuji Urabe8Yasuhiko Kitadai9Fumio Shimamoto10Koji Arihiro11Kazuaki Chayama12Department of Gastroenterology and Metabolism, Hiroshima University HospitalDepartment of Gastroenterology and Metabolism, Hiroshima University HospitalDepartment of Endoscopy, Hiroshima University HospitalDepartment of Gastroenterology and Metabolism, Hiroshima University HospitalDepartment of Gastroenterology and Metabolism, Hiroshima University HospitalDepartment of Gastroenterology and Metabolism, Hiroshima University HospitalDepartment of Gastroenterology and Metabolism, Hiroshima University HospitalDepartment of Endoscopy, Hiroshima University HospitalDepartment of Gastroenterology and Metabolism, Hiroshima University HospitalDepartment of the Faculty of Human Culture and Science, Prefectural University of HiroshimaThe Faculty of Humanities and Human Sciences, Hiroshima Shudo University HiroshimaDepartment of Anatomical Pathology, Hiroshima University HospitalDepartment of Gastroenterology and Metabolism, Hiroshima University HospitalAbstract Background Serrated adenocarcinoma (SAC) is a distinct colorectal carcinoma variant that accounts for approximately 7.5% of all advanced colorectal carcinomas. While its prognosis is worse than conventional carcinoma, its early-stage clinicopathologic features are unclear. We therefore aimed to clarify the clinicopathologic and endoscopic characteristics of early-stage SACs. Methods Forty consecutive early-stage SAC patients at Hiroshima University Hospital were enrolled; SACs were classified into epithelial serration (Group A, n = 17) and non-epithelial serration (Group B, n = 23) groups. Additionally, we classified serrated adenoma into 4 types: sessile serrated adenoma (SSA), traditional serrated adenoma (TSA), unclassified, and non-serrated adenoma type. Results There were significant differences between Groups A and B in terms of tumor size (27.6 vs. 43.1 mm), incidences of T1 carcinoma (71% vs. 13%), and having the same color as normal mucosa (47% vs. 17%), respectively (p <0.01). In SACs >20 mm, the incidence of T1 carcinoma in Group A (70%) was significantly greater than that in Group B (13%) (p <0.05). There were significant differences in ‘Japan NBI Expert Team’ type 3 and type V pit pattern classifications between the 2 groups. The average TSA-type tumor size (42.6 mm) was significantly larger than that of the SSA (17.2 mm) and non-serrated component types (18.3 mm). The incidences of submucosal invasion in SSA- (80%), unclassified- (100%), and non-serrated-type (100%) tumors were significantly higher than that in the TSA type (11%). Conclusions Epithelial serration in the cancerous area and a non-TSA background indicated aggressive behavior in early-stage SACs.http://link.springer.com/article/10.1186/s12876-017-0702-xSerrated adenocarcinomaColorectal cancerNarrow band imagingPit pattern |
| spellingShingle | Daiki Hirano Shiro Oka Shinji Tanaka Kyoku Sumimoto Yuki Ninomiya Yuzuru Tamaru Kenjiro Shigita Nana Hayashi Yuji Urabe Yasuhiko Kitadai Fumio Shimamoto Koji Arihiro Kazuaki Chayama Clinicopathologic and endoscopic features of early-stage colorectal serrated adenocarcinoma BMC Gastroenterology Serrated adenocarcinoma Colorectal cancer Narrow band imaging Pit pattern |
| title | Clinicopathologic and endoscopic features of early-stage colorectal serrated adenocarcinoma |
| title_full | Clinicopathologic and endoscopic features of early-stage colorectal serrated adenocarcinoma |
| title_fullStr | Clinicopathologic and endoscopic features of early-stage colorectal serrated adenocarcinoma |
| title_full_unstemmed | Clinicopathologic and endoscopic features of early-stage colorectal serrated adenocarcinoma |
| title_short | Clinicopathologic and endoscopic features of early-stage colorectal serrated adenocarcinoma |
| title_sort | clinicopathologic and endoscopic features of early stage colorectal serrated adenocarcinoma |
| topic | Serrated adenocarcinoma Colorectal cancer Narrow band imaging Pit pattern |
| url | http://link.springer.com/article/10.1186/s12876-017-0702-x |
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