Cinacalcet for Severe Secondary Hyperparathyroidism in Children with End-stage Kidney Disease
Advanced chronic kidney disease with mineral and bone disorder have a significant obstacles to control serum bone profile [serum intact parathyroid hormone (iPTH), calcium and phosphorus] which subsequently have major effect on optimal bone strength, final adult height, and cardiovascular health. A...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2021;volume=32;issue=6;spage=1628;epage=1636;aulast=Sheerah |
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| author | Areej Adel Sheerah Rafif Ali Al-Ahmed Sherif M. El-Desoky Khalid Abdulaziz Alhasan Amr S. Albanna Mohamed A. Shalaby Jameela Abdulaziz Kari |
| author_facet | Areej Adel Sheerah Rafif Ali Al-Ahmed Sherif M. El-Desoky Khalid Abdulaziz Alhasan Amr S. Albanna Mohamed A. Shalaby Jameela Abdulaziz Kari |
| author_sort | Areej Adel Sheerah |
| collection | DOAJ |
| description | Advanced chronic kidney disease with mineral and bone disorder have a significant obstacles to control serum bone profile [serum intact parathyroid hormone (iPTH), calcium and phosphorus] which subsequently have major effect on optimal bone strength, final adult height, and cardiovascular health. A retrospective, observational study, including a total of 36 children with end-stage kidney disease (ESKD). Fourteen children who were prescribed cinacalcet had been compared with the remaining 22 children who were managed with standard care. We report the efficacy and safety of cinacalcet for treatment of refractory secondary hyperparathyroidism (SHPT) in children with ESKD. After 6 months of cinacalcet treatment, the mean level of iPTH serum level decreased by 56% from 202 pmol/L [95% confidence interval (CI): 150-253] to 88 pmol/L (95% CI: 41-136), compared to the change observed in the control group (P <0.001). None of our patients reported serious adverse effects or developed hypocalcemia. Cinacalcet could be an effective and safe alternative to treat severe SHPT in children with ESKD. Further long-term and large-scale studies are necessary to confirm its safety and efficacy. |
| first_indexed | 2024-04-11T21:41:30Z |
| format | Article |
| id | doaj.art-deb0707842874bd4829439e254001811 |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-04-11T21:41:30Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-deb0707842874bd4829439e2540018112022-12-22T04:01:35ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422021-01-013261628163610.4103/1319-2442.352423Cinacalcet for Severe Secondary Hyperparathyroidism in Children with End-stage Kidney DiseaseAreej Adel SheerahRafif Ali Al-AhmedSherif M. El-DesokyKhalid Abdulaziz AlhasanAmr S. AlbannaMohamed A. ShalabyJameela Abdulaziz KariAdvanced chronic kidney disease with mineral and bone disorder have a significant obstacles to control serum bone profile [serum intact parathyroid hormone (iPTH), calcium and phosphorus] which subsequently have major effect on optimal bone strength, final adult height, and cardiovascular health. A retrospective, observational study, including a total of 36 children with end-stage kidney disease (ESKD). Fourteen children who were prescribed cinacalcet had been compared with the remaining 22 children who were managed with standard care. We report the efficacy and safety of cinacalcet for treatment of refractory secondary hyperparathyroidism (SHPT) in children with ESKD. After 6 months of cinacalcet treatment, the mean level of iPTH serum level decreased by 56% from 202 pmol/L [95% confidence interval (CI): 150-253] to 88 pmol/L (95% CI: 41-136), compared to the change observed in the control group (P <0.001). None of our patients reported serious adverse effects or developed hypocalcemia. Cinacalcet could be an effective and safe alternative to treat severe SHPT in children with ESKD. Further long-term and large-scale studies are necessary to confirm its safety and efficacy.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2021;volume=32;issue=6;spage=1628;epage=1636;aulast=Sheerah |
| spellingShingle | Areej Adel Sheerah Rafif Ali Al-Ahmed Sherif M. El-Desoky Khalid Abdulaziz Alhasan Amr S. Albanna Mohamed A. Shalaby Jameela Abdulaziz Kari Cinacalcet for Severe Secondary Hyperparathyroidism in Children with End-stage Kidney Disease Saudi Journal of Kidney Diseases and Transplantation |
| title | Cinacalcet for Severe Secondary Hyperparathyroidism in Children with End-stage Kidney Disease |
| title_full | Cinacalcet for Severe Secondary Hyperparathyroidism in Children with End-stage Kidney Disease |
| title_fullStr | Cinacalcet for Severe Secondary Hyperparathyroidism in Children with End-stage Kidney Disease |
| title_full_unstemmed | Cinacalcet for Severe Secondary Hyperparathyroidism in Children with End-stage Kidney Disease |
| title_short | Cinacalcet for Severe Secondary Hyperparathyroidism in Children with End-stage Kidney Disease |
| title_sort | cinacalcet for severe secondary hyperparathyroidism in children with end stage kidney disease |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2021;volume=32;issue=6;spage=1628;epage=1636;aulast=Sheerah |
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