Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach
One in five cancers is attributed to infectious agents, and the extent of the impact on the initiation, progression, and disease outcomes may be underestimated. Infection-associated cancers are commonly attributed to viral, and to a lesser extent, parasitic and bacterial etiologies. There is growing...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/18/5659 |
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| author | Rebecca M. Rodriguez Mark Menor Brenda Y. Hernandez Youping Deng Vedbar S. Khadka |
| author_facet | Rebecca M. Rodriguez Mark Menor Brenda Y. Hernandez Youping Deng Vedbar S. Khadka |
| author_sort | Rebecca M. Rodriguez |
| collection | DOAJ |
| description | One in five cancers is attributed to infectious agents, and the extent of the impact on the initiation, progression, and disease outcomes may be underestimated. Infection-associated cancers are commonly attributed to viral, and to a lesser extent, parasitic and bacterial etiologies. There is growing evidence that microbial community variation rather than a single agent can influence cancer development, progression, response to therapy, and outcome. We evaluated microbial sequences from a subset of infection-associated cancers—namely, head and neck squamous cell carcinoma (HNSC), liver hepatocellular carcinoma (LIHC), and stomach adenocarcinoma (STAD) from The Cancer Genome Atlas (TCGA). A total of 470 paired tumor and adjacent normal samples were analyzed. In STAD, concurrent presence of EBV and <i>Selemonas sputigena</i> with a high diversity index were associated with poorer survival (HR: 2.23, 95% CI 1.26–3.94, <i>p</i> = 0.006 and HR: 2.31, 95% CI 1.1–4.9, <i>p</i> = 0.03, respectively). In LIHC, lower microbial diversity was associated with poorer overall survival (HR: 2.57, 95% CI: 1.2, 5.5, <i>p</i> = 0.14). Bacterial within-sample diversity correlates with overall survival in infection-associated cancers in a subset of TCGA cohorts. |
| first_indexed | 2024-03-10T07:23:37Z |
| format | Article |
| id | doaj.art-deb19b9e57b945d682e866d321a575f0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T07:23:37Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-deb19b9e57b945d682e866d321a575f02023-11-22T14:26:32ZengMDPI AGMolecules1420-30492021-09-012618565910.3390/molecules26185659Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and StomachRebecca M. Rodriguez0Mark Menor1Brenda Y. Hernandez2Youping Deng3Vedbar S. Khadka4Bioinformatics Core, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii Mānoa, Honolulu, HI 96813, USABioinformatics Core, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii Mānoa, Honolulu, HI 96813, USAPopulation Sciences in the Pacific Program-Cancer Epidemiology, University of Hawaii Cancer Center, Honolulu, HI 96813, USABioinformatics Core, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii Mānoa, Honolulu, HI 96813, USABioinformatics Core, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii Mānoa, Honolulu, HI 96813, USAOne in five cancers is attributed to infectious agents, and the extent of the impact on the initiation, progression, and disease outcomes may be underestimated. Infection-associated cancers are commonly attributed to viral, and to a lesser extent, parasitic and bacterial etiologies. There is growing evidence that microbial community variation rather than a single agent can influence cancer development, progression, response to therapy, and outcome. We evaluated microbial sequences from a subset of infection-associated cancers—namely, head and neck squamous cell carcinoma (HNSC), liver hepatocellular carcinoma (LIHC), and stomach adenocarcinoma (STAD) from The Cancer Genome Atlas (TCGA). A total of 470 paired tumor and adjacent normal samples were analyzed. In STAD, concurrent presence of EBV and <i>Selemonas sputigena</i> with a high diversity index were associated with poorer survival (HR: 2.23, 95% CI 1.26–3.94, <i>p</i> = 0.006 and HR: 2.31, 95% CI 1.1–4.9, <i>p</i> = 0.03, respectively). In LIHC, lower microbial diversity was associated with poorer overall survival (HR: 2.57, 95% CI: 1.2, 5.5, <i>p</i> = 0.14). Bacterial within-sample diversity correlates with overall survival in infection-associated cancers in a subset of TCGA cohorts.https://www.mdpi.com/1420-3049/26/18/5659microbial diversitytumor microenvironmentinfection-associated cancers |
| spellingShingle | Rebecca M. Rodriguez Mark Menor Brenda Y. Hernandez Youping Deng Vedbar S. Khadka Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach Molecules microbial diversity tumor microenvironment infection-associated cancers |
| title | Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach |
| title_full | Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach |
| title_fullStr | Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach |
| title_full_unstemmed | Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach |
| title_short | Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach |
| title_sort | bacterial diversity correlates with overall survival in cancers of the head and neck liver and stomach |
| topic | microbial diversity tumor microenvironment infection-associated cancers |
| url | https://www.mdpi.com/1420-3049/26/18/5659 |
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