Interaction between mucus layer and gut microbiota in non-alcoholic fatty liver disease: Soil and seeds
Abstract. The intestinal mucus layer is a barrier that separates intestinal contents and epithelial cells, as well as acts as the "mucus layer-soil" for intestinal flora adhesion and colonization. Its structural and functional integrity is crucial to human health. Intestinal mucus is regul...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2023-06-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000002711 |
| _version_ | 1827913173126086656 |
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| author | Binbin Zhang Jie Li Jinlong Fu Li Shao Luping Yang Junping Shi Jinjiao Li Yuanyuan Ji |
| author_facet | Binbin Zhang Jie Li Jinlong Fu Li Shao Luping Yang Junping Shi Jinjiao Li Yuanyuan Ji |
| author_sort | Binbin Zhang |
| collection | DOAJ |
| description | Abstract. The intestinal mucus layer is a barrier that separates intestinal contents and epithelial cells, as well as acts as the "mucus layer-soil" for intestinal flora adhesion and colonization. Its structural and functional integrity is crucial to human health. Intestinal mucus is regulated by factors such as diet, living habits, hormones, neurotransmitters, cytokines, and intestinal flora. The mucus layer's thickness, viscosity, porosity, growth rate, and glycosylation status affect the structure of the gut flora colonized on it. The interaction between "mucus layer-soil" and "gut bacteria-seed" is an important factor leading to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Probiotics, prebiotics, fecal microbiota transplantation (FMT), and wash microbial transplantation are efficient methods for managing NAFLD, but their long-term efficacy is poor. FMT is focused on achieving the goal of treating diseases by enhancing the "gut bacteria-seed". However, a lack of effective repair and management of the "mucus layer-soil" may be a reason why "seeds" cannot be well colonized and grow in the host gut, as the thinning and destruction of the "mucus layer-soil" is an early symptom of NAFLD. This review summarizes the existing correlation between intestinal mucus and gut microbiota, as well as the pathogenesis of NAFLD, and proposes a new perspective that "mucus layer-soil" restoration combined with "gut bacteria-seed" FMT may be one of the most effective future strategies for enhancing the long-term efficacy of NAFLD treatment. |
| first_indexed | 2024-03-13T02:26:32Z |
| format | Article |
| id | doaj.art-deb1c697c29440ee991ee186c6d4ba9e |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-03-13T02:26:32Z |
| publishDate | 2023-06-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-deb1c697c29440ee991ee186c6d4ba9e2023-06-30T01:54:37ZengWolters KluwerChinese Medical Journal0366-69992542-56412023-06-01136121390140010.1097/CM9.0000000000002711202306200-00002Interaction between mucus layer and gut microbiota in non-alcoholic fatty liver disease: Soil and seedsBinbin Zhang0Jie Li1Jinlong Fu2Li Shao3Luping Yang4Junping Shi5Jinjiao LiYuanyuan Ji1Department of Translational Medicine Platform, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310015, China3Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 210008, China4Department of School of Clinical Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China1Department of Translational Medicine Platform, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310015, China5Department of Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China1Department of Translational Medicine Platform, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310015, ChinaAbstract. The intestinal mucus layer is a barrier that separates intestinal contents and epithelial cells, as well as acts as the "mucus layer-soil" for intestinal flora adhesion and colonization. Its structural and functional integrity is crucial to human health. Intestinal mucus is regulated by factors such as diet, living habits, hormones, neurotransmitters, cytokines, and intestinal flora. The mucus layer's thickness, viscosity, porosity, growth rate, and glycosylation status affect the structure of the gut flora colonized on it. The interaction between "mucus layer-soil" and "gut bacteria-seed" is an important factor leading to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Probiotics, prebiotics, fecal microbiota transplantation (FMT), and wash microbial transplantation are efficient methods for managing NAFLD, but their long-term efficacy is poor. FMT is focused on achieving the goal of treating diseases by enhancing the "gut bacteria-seed". However, a lack of effective repair and management of the "mucus layer-soil" may be a reason why "seeds" cannot be well colonized and grow in the host gut, as the thinning and destruction of the "mucus layer-soil" is an early symptom of NAFLD. This review summarizes the existing correlation between intestinal mucus and gut microbiota, as well as the pathogenesis of NAFLD, and proposes a new perspective that "mucus layer-soil" restoration combined with "gut bacteria-seed" FMT may be one of the most effective future strategies for enhancing the long-term efficacy of NAFLD treatment.http://journals.lww.com/10.1097/CM9.0000000000002711 |
| spellingShingle | Binbin Zhang Jie Li Jinlong Fu Li Shao Luping Yang Junping Shi Jinjiao Li Yuanyuan Ji Interaction between mucus layer and gut microbiota in non-alcoholic fatty liver disease: Soil and seeds Chinese Medical Journal |
| title | Interaction between mucus layer and gut microbiota in non-alcoholic fatty liver disease: Soil and seeds |
| title_full | Interaction between mucus layer and gut microbiota in non-alcoholic fatty liver disease: Soil and seeds |
| title_fullStr | Interaction between mucus layer and gut microbiota in non-alcoholic fatty liver disease: Soil and seeds |
| title_full_unstemmed | Interaction between mucus layer and gut microbiota in non-alcoholic fatty liver disease: Soil and seeds |
| title_short | Interaction between mucus layer and gut microbiota in non-alcoholic fatty liver disease: Soil and seeds |
| title_sort | interaction between mucus layer and gut microbiota in non alcoholic fatty liver disease soil and seeds |
| url | http://journals.lww.com/10.1097/CM9.0000000000002711 |
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