Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory

Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory

The histone modification H3K27me3 plays a central role in Polycomb-mediated epigenetic silencing. H3K27me3 recruits and allosterically activates Polycomb Repressive Complex 2 (PRC2), which adds this modification to nearby histones, providing a read/write mechanism for inheritance through DNA replica...

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Bibliographic Details
Main Authors: Cecilia Lövkvist, Pawel Mikulski, Svenja Reeck, Matthew Hartley, Caroline Dean, Martin Howard
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
FLC
epigenetics
mathematical modelling
PRC2
polycomb
H3K27me3
Online Access:https://elifesciences.org/articles/66454

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