Effects of levocarnitine on cardiac function, urinary albumin, hs-CRP, BNP, and troponin in patients with coronary heart disease and heart failure
Objective: To investigate the effects of levocarnitine on cardiac function, urinary albumin (ALB), high-sensitivity C-reactive protein (hs-CRP), brain natriuretic peptide (BNP), and troponin in patients with coronary heart disease (CHD) and heart failure (HF). Methods: In total, 246 patients with CH...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-03-01
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| Series: | Hellenic Journal of Cardiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1109966618300058 |
| _version_ | 1818422327796301824 |
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| author | Guoliang Zhao Haiying Zhang Yi Wang Xiaohui Gao Huaqing Liu Wei Liu |
| author_facet | Guoliang Zhao Haiying Zhang Yi Wang Xiaohui Gao Huaqing Liu Wei Liu |
| author_sort | Guoliang Zhao |
| collection | DOAJ |
| description | Objective: To investigate the effects of levocarnitine on cardiac function, urinary albumin (ALB), high-sensitivity C-reactive protein (hs-CRP), brain natriuretic peptide (BNP), and troponin in patients with coronary heart disease (CHD) and heart failure (HF). Methods: In total, 246 patients with CHD-caused HF were selected and randomly divided into Group A and Group B. A fully automatic biochemical analyzer was used to measure the levels of ALB, hs-CRP, BNP, and troponin in both groups of patients, and the expression levels of LVDD and LVEF were detected by cardiac color ultrasonography. Patients in Group B were intravenously injected with 3.0 g of levocarnitine, once per day. After 14 days, changes in levels of ALB, hs-CRP, BNP, troponin, LVDD, and LVEF in Group A patients were detected. Results: The effective cure rates of patients in both groups were 65.8% and 81.3%, respectively, and there was a statistically significant difference between the two groups (p < 0.05). After administration of levocarnitine, all indicators showed decreasing trends, but the LVEF level increased. Among them, patients treated with levocarnitine showed the most evident decrease in LVEF. Decrease in BNP was the largest (p < 0.05). Additionally, there was no statistical difference in incidence rate between the two groups (5.8% vs. 2.5%, p = 0.222). Conclusion: Levocarnitine can effectively improve ALB, hs-CRP, BNP, troponin, and LVDD levels to improve cardiac function rating and thus improve cardiac function. |
| first_indexed | 2024-12-14T13:24:30Z |
| format | Article |
| id | doaj.art-deb20eb1256d4718970d344e3a0d8da9 |
| institution | Directory Open Access Journal |
| issn | 1109-9666 |
| language | English |
| last_indexed | 2024-12-14T13:24:30Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hellenic Journal of Cardiology |
| spelling | doaj.art-deb20eb1256d4718970d344e3a0d8da92022-12-21T22:59:51ZengElsevierHellenic Journal of Cardiology1109-96662020-03-0161299102Effects of levocarnitine on cardiac function, urinary albumin, hs-CRP, BNP, and troponin in patients with coronary heart disease and heart failureGuoliang Zhao0Haiying Zhang1Yi Wang2Xiaohui Gao3Huaqing Liu4Wei Liu5Emergency Internal Medicine, The First People's Hospital of Jining, Jining 272011, PR ChinaClinical Laboratory, People's Hospital of Lanshan District, Rizhao 276800, PR ChinaDepartment of Respiration, People's Hospital of Zhangqiu District, Jinan 250000, PR ChinaMagnetic Resonance, People's Hospital of Zhangqiu District, Jinan 250000, PR ChinaDepartment of Neurology, People's Hospital of Zhangqiu District, Jinan 250000, PR ChinaEmergent Intensive Care Unit, The First People's Hospital of Jining, Jining 272011, PR China; Corresponding author. Wei Liu, Emergent Intensive Care Unit, The First People's Hospital of Jining, No.6 Jiankang Road, Jining 272011, PR China.Objective: To investigate the effects of levocarnitine on cardiac function, urinary albumin (ALB), high-sensitivity C-reactive protein (hs-CRP), brain natriuretic peptide (BNP), and troponin in patients with coronary heart disease (CHD) and heart failure (HF). Methods: In total, 246 patients with CHD-caused HF were selected and randomly divided into Group A and Group B. A fully automatic biochemical analyzer was used to measure the levels of ALB, hs-CRP, BNP, and troponin in both groups of patients, and the expression levels of LVDD and LVEF were detected by cardiac color ultrasonography. Patients in Group B were intravenously injected with 3.0 g of levocarnitine, once per day. After 14 days, changes in levels of ALB, hs-CRP, BNP, troponin, LVDD, and LVEF in Group A patients were detected. Results: The effective cure rates of patients in both groups were 65.8% and 81.3%, respectively, and there was a statistically significant difference between the two groups (p < 0.05). After administration of levocarnitine, all indicators showed decreasing trends, but the LVEF level increased. Among them, patients treated with levocarnitine showed the most evident decrease in LVEF. Decrease in BNP was the largest (p < 0.05). Additionally, there was no statistical difference in incidence rate between the two groups (5.8% vs. 2.5%, p = 0.222). Conclusion: Levocarnitine can effectively improve ALB, hs-CRP, BNP, troponin, and LVDD levels to improve cardiac function rating and thus improve cardiac function.http://www.sciencedirect.com/science/article/pii/S1109966618300058Coronary heart disease-caused heart failureHeart functionBNPhs-CRPLevocarnitine |
| spellingShingle | Guoliang Zhao Haiying Zhang Yi Wang Xiaohui Gao Huaqing Liu Wei Liu Effects of levocarnitine on cardiac function, urinary albumin, hs-CRP, BNP, and troponin in patients with coronary heart disease and heart failure Hellenic Journal of Cardiology Coronary heart disease-caused heart failure Heart function BNP hs-CRP Levocarnitine |
| title | Effects of levocarnitine on cardiac function, urinary albumin, hs-CRP, BNP, and troponin in patients with coronary heart disease and heart failure |
| title_full | Effects of levocarnitine on cardiac function, urinary albumin, hs-CRP, BNP, and troponin in patients with coronary heart disease and heart failure |
| title_fullStr | Effects of levocarnitine on cardiac function, urinary albumin, hs-CRP, BNP, and troponin in patients with coronary heart disease and heart failure |
| title_full_unstemmed | Effects of levocarnitine on cardiac function, urinary albumin, hs-CRP, BNP, and troponin in patients with coronary heart disease and heart failure |
| title_short | Effects of levocarnitine on cardiac function, urinary albumin, hs-CRP, BNP, and troponin in patients with coronary heart disease and heart failure |
| title_sort | effects of levocarnitine on cardiac function urinary albumin hs crp bnp and troponin in patients with coronary heart disease and heart failure |
| topic | Coronary heart disease-caused heart failure Heart function BNP hs-CRP Levocarnitine |
| url | http://www.sciencedirect.com/science/article/pii/S1109966618300058 |
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