Novel dandelion mannan-lipid nanoparticle: Exploring the molecular mechanism underlying the potent anticancer effect against non-small lung carcinoma

Novel dandelion mannan-lipid nanoparticle: Exploring the molecular mechanism underlying the potent anticancer effect against non-small lung carcinoma

New β-branched glucomannan (TOPL) with an average molecular weight (4.29 × 104 Da) was purified from dandelion leaves for the first time. TOPL possesses a potent IC50 against non-small lung carcinoma (NSCLC); A549 and H460 cell lines (4.01 and 6.57 μg/ml), respectively. To improve the drug-like prop...

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Bibliographic Details
Main Authors: Soad Z. El-Emam, Dina Moustafa Abo El-Ella, Sahar M. Fayez, Mohsen Asker, Jilan A. Nazeam
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Journal of Functional Foods
Subjects:
Solid lipid nanoparticles
Taraxacum officinale
Dandelion
Mannan
Autophagy
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621004308

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