Functional Dizziness as a Spatial Cognitive Dysfunction
(1) Background: Persistent postural-perceptual dizziness (PPPD) is a common chronic dizziness disorder with an unclear pathophysiology. It is hypothesized that PPPD may involve disrupted spatial cognition processes as a core feature. (2) Methods: A cohort of 19 PPPD patients underwent psycho-cogniti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/14/1/16 |
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| author | Hayo A. Breinbauer Camilo Arévalo-Romero Karen Villarroel Claudio Lavin Felipe Faúndez Rosario Garrido Kevin Alarcón Ximena Stecher Francisco Zamorano Pablo Billeke Paul H. Delano |
| author_facet | Hayo A. Breinbauer Camilo Arévalo-Romero Karen Villarroel Claudio Lavin Felipe Faúndez Rosario Garrido Kevin Alarcón Ximena Stecher Francisco Zamorano Pablo Billeke Paul H. Delano |
| author_sort | Hayo A. Breinbauer |
| collection | DOAJ |
| description | (1) Background: Persistent postural-perceptual dizziness (PPPD) is a common chronic dizziness disorder with an unclear pathophysiology. It is hypothesized that PPPD may involve disrupted spatial cognition processes as a core feature. (2) Methods: A cohort of 19 PPPD patients underwent psycho-cognitive testing, including assessments for anxiety, depression, memory, attention, planning, and executive functions, with an emphasis on spatial navigation via a virtual Morris water maze. These patients were compared with 12 healthy controls and 20 individuals with other vestibular disorders but without PPPD. Vestibular function was evaluated using video head impulse testing and vestibular evoked myogenic potentials, while brain magnetic resonance imaging was used to exclude confounding pathology. (3) Results: PPPD patients demonstrated unique impairments in allocentric spatial navigation (as evidenced by the virtual Morris water maze) and in other high-demand visuospatial cognitive tasks that involve executive functions and planning, such as the Towers of London and Trail Making B tests. A factor analysis highlighted spatial navigation and advanced visuospatial functions as being central to PPPD, with a strong correlation to symptom severity. (4) Conclusions: PPPD may broadly impair higher cognitive functions, especially in spatial cognition. We discuss a disruption in the creation of enriched cognitive spatial maps as a possible pathophysiology for PPPD. |
| first_indexed | 2024-03-08T11:03:44Z |
| format | Article |
| id | doaj.art-deb496a1e50b43cd964c9aa6bcb9283d |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-08T11:03:44Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-deb496a1e50b43cd964c9aa6bcb9283d2024-01-26T15:23:31ZengMDPI AGBrain Sciences2076-34252023-12-011411610.3390/brainsci14010016Functional Dizziness as a Spatial Cognitive DysfunctionHayo A. Breinbauer0Camilo Arévalo-Romero1Karen Villarroel2Claudio Lavin3Felipe Faúndez4Rosario Garrido5Kevin Alarcón6Ximena Stecher7Francisco Zamorano8Pablo Billeke9Paul H. Delano10Laboratory for Clinical Neuro-Otology and Balance-Neuroscience, Department of Neuroscience, Facultad de Medicina, Universidad de Chile, Santiago 8331150, ChileLaboratory for Clinical Neuro-Otology and Balance-Neuroscience, Department of Neuroscience, Facultad de Medicina, Universidad de Chile, Santiago 8331150, ChileLaboratory for Clinical Neuro-Otology and Balance-Neuroscience, Department of Neuroscience, Facultad de Medicina, Universidad de Chile, Santiago 8331150, ChileLaboratorio de Neurociencia Social y Neuromodulación, Centro de Investigación en Complejidad Social (neuroCICS), Facultad de Gobierno, Universidad del Desarrollo, Santiago 7610615, ChileLaboratory for Clinical Neuro-Otology and Balance-Neuroscience, Department of Neuroscience, Facultad de Medicina, Universidad de Chile, Santiago 8331150, ChileLaboratory for Clinical Neuro-Otology and Balance-Neuroscience, Department of Neuroscience, Facultad de Medicina, Universidad de Chile, Santiago 8331150, ChileLaboratory for Clinical Neuro-Otology and Balance-Neuroscience, Department of Neuroscience, Facultad de Medicina, Universidad de Chile, Santiago 8331150, ChileDepartment of Radiology, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7610615, ChileDepartment of Radiology, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7610615, ChileLaboratorio de Neurociencia Social y Neuromodulación, Centro de Investigación en Complejidad Social (neuroCICS), Facultad de Gobierno, Universidad del Desarrollo, Santiago 7610615, ChileLaboratory for Clinical Neuro-Otology and Balance-Neuroscience, Department of Neuroscience, Facultad de Medicina, Universidad de Chile, Santiago 8331150, Chile(1) Background: Persistent postural-perceptual dizziness (PPPD) is a common chronic dizziness disorder with an unclear pathophysiology. It is hypothesized that PPPD may involve disrupted spatial cognition processes as a core feature. (2) Methods: A cohort of 19 PPPD patients underwent psycho-cognitive testing, including assessments for anxiety, depression, memory, attention, planning, and executive functions, with an emphasis on spatial navigation via a virtual Morris water maze. These patients were compared with 12 healthy controls and 20 individuals with other vestibular disorders but without PPPD. Vestibular function was evaluated using video head impulse testing and vestibular evoked myogenic potentials, while brain magnetic resonance imaging was used to exclude confounding pathology. (3) Results: PPPD patients demonstrated unique impairments in allocentric spatial navigation (as evidenced by the virtual Morris water maze) and in other high-demand visuospatial cognitive tasks that involve executive functions and planning, such as the Towers of London and Trail Making B tests. A factor analysis highlighted spatial navigation and advanced visuospatial functions as being central to PPPD, with a strong correlation to symptom severity. (4) Conclusions: PPPD may broadly impair higher cognitive functions, especially in spatial cognition. We discuss a disruption in the creation of enriched cognitive spatial maps as a possible pathophysiology for PPPD.https://www.mdpi.com/2076-3425/14/1/16persistent postural perceptual dizzinessfunctional dizzinessspatial navigationspatial cognitionfunctional neurological disorderchronic dizziness |
| spellingShingle | Hayo A. Breinbauer Camilo Arévalo-Romero Karen Villarroel Claudio Lavin Felipe Faúndez Rosario Garrido Kevin Alarcón Ximena Stecher Francisco Zamorano Pablo Billeke Paul H. Delano Functional Dizziness as a Spatial Cognitive Dysfunction Brain Sciences persistent postural perceptual dizziness functional dizziness spatial navigation spatial cognition functional neurological disorder chronic dizziness |
| title | Functional Dizziness as a Spatial Cognitive Dysfunction |
| title_full | Functional Dizziness as a Spatial Cognitive Dysfunction |
| title_fullStr | Functional Dizziness as a Spatial Cognitive Dysfunction |
| title_full_unstemmed | Functional Dizziness as a Spatial Cognitive Dysfunction |
| title_short | Functional Dizziness as a Spatial Cognitive Dysfunction |
| title_sort | functional dizziness as a spatial cognitive dysfunction |
| topic | persistent postural perceptual dizziness functional dizziness spatial navigation spatial cognition functional neurological disorder chronic dizziness |
| url | https://www.mdpi.com/2076-3425/14/1/16 |
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