Morphometric Analysis of Brain in Newborn with Congenital Diaphragmatic Hernia
Congenital diaphragmatic hernia (CDH) is a severe pediatric disorder with herniation of abdominal viscera into the thoracic cavity. Since neurodevelopmental impairment constitutes a common outcome, we performed morphometric magnetic resonance imaging (MRI) analysis on CDH infants to investigate cort...
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| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/4/455 |
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| author | Martina Lucignani Daniela Longo Elena Fontana Maria Camilla Rossi-Espagnet Giulia Lucignani Sara Savelli Stefano Bascetta Stefania Sgrò Francesco Morini Paola Giliberti Antonio Napolitano |
| author_facet | Martina Lucignani Daniela Longo Elena Fontana Maria Camilla Rossi-Espagnet Giulia Lucignani Sara Savelli Stefano Bascetta Stefania Sgrò Francesco Morini Paola Giliberti Antonio Napolitano |
| author_sort | Martina Lucignani |
| collection | DOAJ |
| description | Congenital diaphragmatic hernia (CDH) is a severe pediatric disorder with herniation of abdominal viscera into the thoracic cavity. Since neurodevelopmental impairment constitutes a common outcome, we performed morphometric magnetic resonance imaging (MRI) analysis on CDH infants to investigate cortical parameters such as cortical thickness (CT) and local gyrification index (LGI). By assessing CT and LGI distributions and their correlations with variables which might have an impact on oxygen delivery (total lung volume, TLV), we aimed to detect how altered perfusion affects cortical development in CDH. A group of CDH patients received both prenatal (i.e., fetal stage) and postnatal MRI. From postnatal high-resolution T2-weighted images, mean CT and LGI distributions of 16 CDH were computed and statistically compared to those of 13 controls. Moreover, TLV measures obtained from fetal MRI were further correlated to LGI. Compared to controls, CDH infants exhibited areas of hypogiria within bilateral fronto-temporo-parietal labels, while no differences were found for CT. LGI significantly correlated with TLV within bilateral temporal lobes and left frontal lobe, involving language- and auditory-related brain areas. Although the causes of neurodevelopmental impairment in CDH are still unclear, our results may suggest their link with altered cortical maturation and possible impaired oxygen perfusion. |
| first_indexed | 2024-03-10T12:39:06Z |
| format | Article |
| id | doaj.art-deb728957e5e49aba16dbde127a28e00 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T12:39:06Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-deb728957e5e49aba16dbde127a28e002023-11-21T14:04:51ZengMDPI AGBrain Sciences2076-34252021-04-0111445510.3390/brainsci11040455Morphometric Analysis of Brain in Newborn with Congenital Diaphragmatic HerniaMartina Lucignani0Daniela Longo1Elena Fontana2Maria Camilla Rossi-Espagnet3Giulia Lucignani4Sara Savelli5Stefano Bascetta6Stefania Sgrò7Francesco Morini8Paola Giliberti9Antonio Napolitano10Medical Physics Department, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyNeuroradiology Unit, Imaging Department, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyNeuroradiology Unit, Imaging Department, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyNeuroradiology Unit, Imaging Department, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyNeuroradiology Unit, Imaging Department, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyImaging Department, Bambino Gesù Children’s Hospital and Research Institute, 00165 Rome, ItalyImaging Department, Bambino Gesù Children’s Hospital and Research Institute, 00165 Rome, ItalyDepartment of Anesthesia and Critical Care, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyDepartment of Medical and Surgical Neonatology, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyDepartment of Medical and Surgical Neonatology, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyMedical Physics Department, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyCongenital diaphragmatic hernia (CDH) is a severe pediatric disorder with herniation of abdominal viscera into the thoracic cavity. Since neurodevelopmental impairment constitutes a common outcome, we performed morphometric magnetic resonance imaging (MRI) analysis on CDH infants to investigate cortical parameters such as cortical thickness (CT) and local gyrification index (LGI). By assessing CT and LGI distributions and their correlations with variables which might have an impact on oxygen delivery (total lung volume, TLV), we aimed to detect how altered perfusion affects cortical development in CDH. A group of CDH patients received both prenatal (i.e., fetal stage) and postnatal MRI. From postnatal high-resolution T2-weighted images, mean CT and LGI distributions of 16 CDH were computed and statistically compared to those of 13 controls. Moreover, TLV measures obtained from fetal MRI were further correlated to LGI. Compared to controls, CDH infants exhibited areas of hypogiria within bilateral fronto-temporo-parietal labels, while no differences were found for CT. LGI significantly correlated with TLV within bilateral temporal lobes and left frontal lobe, involving language- and auditory-related brain areas. Although the causes of neurodevelopmental impairment in CDH are still unclear, our results may suggest their link with altered cortical maturation and possible impaired oxygen perfusion.https://www.mdpi.com/2076-3425/11/4/455magnetic resonance imaging (MRI)congenital diaphragmatic hernia (CDH)cortical thickness (CT)local gyrification index (LGI)total lung volume (TLV) |
| spellingShingle | Martina Lucignani Daniela Longo Elena Fontana Maria Camilla Rossi-Espagnet Giulia Lucignani Sara Savelli Stefano Bascetta Stefania Sgrò Francesco Morini Paola Giliberti Antonio Napolitano Morphometric Analysis of Brain in Newborn with Congenital Diaphragmatic Hernia Brain Sciences magnetic resonance imaging (MRI) congenital diaphragmatic hernia (CDH) cortical thickness (CT) local gyrification index (LGI) total lung volume (TLV) |
| title | Morphometric Analysis of Brain in Newborn with Congenital Diaphragmatic Hernia |
| title_full | Morphometric Analysis of Brain in Newborn with Congenital Diaphragmatic Hernia |
| title_fullStr | Morphometric Analysis of Brain in Newborn with Congenital Diaphragmatic Hernia |
| title_full_unstemmed | Morphometric Analysis of Brain in Newborn with Congenital Diaphragmatic Hernia |
| title_short | Morphometric Analysis of Brain in Newborn with Congenital Diaphragmatic Hernia |
| title_sort | morphometric analysis of brain in newborn with congenital diaphragmatic hernia |
| topic | magnetic resonance imaging (MRI) congenital diaphragmatic hernia (CDH) cortical thickness (CT) local gyrification index (LGI) total lung volume (TLV) |
| url | https://www.mdpi.com/2076-3425/11/4/455 |
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