Mosquito CYP4C21 knockout reduces dengue virus and Zika virus replication in Aedes aegypti cells

Mosquito CYP4C21 knockout reduces dengue virus and Zika virus replication in Aedes aegypti cells

Aedes aegypti (Ae. aegypti) is a major vector of dengue virus (DENV) and Zika virus (ZIKV). Understanding the complex interaction mechanisms between mosquito vectors and arboviruses is essential to interrupt virus transmission. This study constructed CYP4C21 knockout (KO) Aag2 cells (Ae. aegypti cel...

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Bibliographic Details
Main Authors:	Xiaoxue Xie, Di Wang, Bo Li, Manjin Li, Dan Xing, Teng Zhao, Xinyu Zhou, Chunxiao Li
Format:	Article
Language:	English
Published:	Elsevier 2023-06-01
Series:	Biosafety and Health
Subjects:	CYP4C21 Aag2 cell DENV2 ZIKV CRISPR/Cas9
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590053623000496

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