Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors
ABSTRACT Atypical teratoid/rhabdoid tumors (AT/RTs) are lethal central nervous system tumors, which are primarily diagnosed in infants. Current treatments for AT/RTs include surgery, radiotherapy, and chemotherapy; these treatments have poor prognoses and challenging side effects. The pivotal geneti...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-06-01
|
| Series: | Pediatric Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ped4.12325 |
| _version_ | 1828315027060293632 |
|---|---|
| author | Chang Zhang Hao Li |
| author_facet | Chang Zhang Hao Li |
| author_sort | Chang Zhang |
| collection | DOAJ |
| description | ABSTRACT Atypical teratoid/rhabdoid tumors (AT/RTs) are lethal central nervous system tumors, which are primarily diagnosed in infants. Current treatments for AT/RTs include surgery, radiotherapy, and chemotherapy; these treatments have poor prognoses and challenging side effects. The pivotal genetic event in AT/RT pathogenesis comprises the inactivation of SMARCB1 or SMARCA4. Recent epigenetic studies have demonstrated mutual and subtype‐specific epigenetic derangements that drive tumorigenesis; the exploitation of these potential targets might improve the dismal treatment outcomes of AT/RTs. This review aims to summarize the literature concerning targeted molecular therapies for pediatric AT/RTs. |
| first_indexed | 2024-04-13T16:54:23Z |
| format | Article |
| id | doaj.art-deb8dc379d9b45548ac4cf373ec0c5e3 |
| institution | Directory Open Access Journal |
| issn | 2574-2272 |
| language | English |
| last_indexed | 2024-04-13T16:54:23Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pediatric Investigation |
| spelling | doaj.art-deb8dc379d9b45548ac4cf373ec0c5e32022-12-22T02:38:51ZengWileyPediatric Investigation2574-22722022-06-016211112210.1002/ped4.12325Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumorsChang Zhang0Hao Li1Department of Neurosurgery Children's Hospital of Fudan University Shanghai ChinaDepartment of Neurosurgery Children's Hospital of Fudan University Shanghai ChinaABSTRACT Atypical teratoid/rhabdoid tumors (AT/RTs) are lethal central nervous system tumors, which are primarily diagnosed in infants. Current treatments for AT/RTs include surgery, radiotherapy, and chemotherapy; these treatments have poor prognoses and challenging side effects. The pivotal genetic event in AT/RT pathogenesis comprises the inactivation of SMARCB1 or SMARCA4. Recent epigenetic studies have demonstrated mutual and subtype‐specific epigenetic derangements that drive tumorigenesis; the exploitation of these potential targets might improve the dismal treatment outcomes of AT/RTs. This review aims to summarize the literature concerning targeted molecular therapies for pediatric AT/RTs.https://doi.org/10.1002/ped4.12325Atypical teratoid/rhabdoid tumorsSMARCB1SMARCA4SWI/SNF complexTargeted molecular therapy |
| spellingShingle | Chang Zhang Hao Li Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors Pediatric Investigation Atypical teratoid/rhabdoid tumors SMARCB1 SMARCA4 SWI/SNF complex Targeted molecular therapy |
| title | Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors |
| title_full | Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors |
| title_fullStr | Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors |
| title_full_unstemmed | Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors |
| title_short | Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors |
| title_sort | molecular targeted therapies for pediatric atypical teratoid rhabdoid tumors |
| topic | Atypical teratoid/rhabdoid tumors SMARCB1 SMARCA4 SWI/SNF complex Targeted molecular therapy |
| url | https://doi.org/10.1002/ped4.12325 |
| work_keys_str_mv | AT changzhang moleculartargetedtherapiesforpediatricatypicalteratoidrhabdoidtumors AT haoli moleculartargetedtherapiesforpediatricatypicalteratoidrhabdoidtumors |