| Summary: | <p><strong>Aim.</strong> Comparative study of choroidea, retina ganglion cell complex (GCC) and regional hemodynamics in primary open angle (POAG) and pseudoexfoliative glaucoma (PEG) patients.</p><p><strong>Materials and methods.</strong> 40 POAG patients and 36 PEG patients with the same disease stage were observed. MD –1.52±0.27 in POAG group and –2.38±0.35 in PEG group (p = 0. 069). Subjects were age-matched (ranged from 60 to 70 years: 69.41±1.207 66.32±0.75 in PEG group;<br />p = 0.32) and comparable for axial eye length (24.08±0.38 in POAG group, 23.48±0.27 in PEG group; p = 0.208).<br /><strong>Results.</strong> Significant difference in focal loss of retinal ganglion cells (FLV) between POAG and PEG groups was revealed (1.875±0.399 and 3.535±0.684, respectively; p = 0.035). Choroidea thickness decrease was discovered in PEG patients as compared with POAG patients: 219.55±17.81 and 266.93±15.9, respectively, at the fovea (p = 0.048);<br />and 117.1±10.1 and 158.3±14.8, respectively, at the peripapillary area (p = 0.026). The reduction of blood flow velocity in ophthalmic artery (29.08±2.38 cm / sec), central retinal vein (5.22±0.29 cm / sec) and superior ophthalmic vein (5.22±0.29 cm / sec) were observed in PEG group as compared with POAG group (34.10±1.47, 7.54±0.53 and<br />6.47±0.33 cm / sec, respectively). The significance of these differences is confirmed by the following data: p = 0.05 (for Vsyst in ophthalmic artery), р = 0.012 (for Vsyst in central retinal vein) and p = 0.007 (for Vmean in superior ophthalmic vein).<br /><strong>Conclusion</strong>. At the same disease stage, PEG is characterized by greater choroidea thinning, GCC damage and reduced blood flow in large retrobulbar vessels as compared with POAG.</p>
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