Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review
Background: Sarcomas comprise approximately 1% of all human malignancies; treatment resistance is one of the major reasons for the poor prognosis of sarcomas. Accumulating evidence suggests that non-coding RNAs (ncRNAs), including miRNAs, long ncRNAs, and circular RNAs, are important molecules invol...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2022-11-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/79655 |
| _version_ | 1811304933557796864 |
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| author | Huan-Huan Chen Tie-Ning Zhang Fang-Yuan Zhang Tao Zhang |
| author_facet | Huan-Huan Chen Tie-Ning Zhang Fang-Yuan Zhang Tao Zhang |
| author_sort | Huan-Huan Chen |
| collection | DOAJ |
| description | Background: Sarcomas comprise approximately 1% of all human malignancies; treatment resistance is one of the major reasons for the poor prognosis of sarcomas. Accumulating evidence suggests that non-coding RNAs (ncRNAs), including miRNAs, long ncRNAs, and circular RNAs, are important molecules involved in the crosstalk between resistance to chemotherapy, targeted therapy, and radiotherapy via various pathways.
Methods: We searched the PubMed (MEDLINE) database for articles regarding sarcoma-associated ncRNAs from inception to August 17, 2022. Studies investigating the roles of host-derived miRNAs, long ncRNAs, and circular RNAs in sarcoma were included. Data relating to the roles of ncRNAs in therapeutic regulation and their applicability as biomarkers for predicting the therapeutic response of sarcomas were extracted. Two independent researchers assessed the quality of the studies using the Würzburg Methodological Quality Score (W-MeQS).
Results: Observational studies revealed the ectopic expression of ncRNAs in sarcoma patients who had different responses to antitumor treatments. Experimental studies have confirmed crosstalk between cellular pathways pertinent to chemotherapy, targeted therapy, and radiotherapy resistance. Of the included studies, W-MeQS scores ranged from 3 to 10 (average score = 5.42). Of the 12 articles that investigated ncRNAs as biomarkers, none included a validation cohort. Selective reporting of the sensitivity, specificity, and receiver operating curves was common.
Conclusions: Although ncRNAs appear to be good candidates as biomarkers for predicting treatment response and therapeutics for sarcoma, their differential expression across tissues complicates their application. Further research regarding their potential for inhibiting or activating these regulatory molecules to reverse treatment resistance may be useful.
Funding: This study’s literature retrieval was supported financially by the 345 Talent Project of Shengjing Hospital of China Medical University (M0949 to Tao Zhang). |
| first_indexed | 2024-04-13T08:16:17Z |
| format | Article |
| id | doaj.art-dec0215881d942d6a36752f86356c9e1 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-13T08:16:17Z |
| publishDate | 2022-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-dec0215881d942d6a36752f86356c9e12022-12-22T02:54:48ZengeLife Sciences Publications LtdeLife2050-084X2022-11-011110.7554/eLife.79655Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic reviewHuan-Huan Chen0Tie-Ning Zhang1Fang-Yuan Zhang2https://orcid.org/0000-0002-1551-6048Tao Zhang3https://orcid.org/0000-0001-5341-8249Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of General Surgery, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, ChinaBackground: Sarcomas comprise approximately 1% of all human malignancies; treatment resistance is one of the major reasons for the poor prognosis of sarcomas. Accumulating evidence suggests that non-coding RNAs (ncRNAs), including miRNAs, long ncRNAs, and circular RNAs, are important molecules involved in the crosstalk between resistance to chemotherapy, targeted therapy, and radiotherapy via various pathways. Methods: We searched the PubMed (MEDLINE) database for articles regarding sarcoma-associated ncRNAs from inception to August 17, 2022. Studies investigating the roles of host-derived miRNAs, long ncRNAs, and circular RNAs in sarcoma were included. Data relating to the roles of ncRNAs in therapeutic regulation and their applicability as biomarkers for predicting the therapeutic response of sarcomas were extracted. Two independent researchers assessed the quality of the studies using the Würzburg Methodological Quality Score (W-MeQS). Results: Observational studies revealed the ectopic expression of ncRNAs in sarcoma patients who had different responses to antitumor treatments. Experimental studies have confirmed crosstalk between cellular pathways pertinent to chemotherapy, targeted therapy, and radiotherapy resistance. Of the included studies, W-MeQS scores ranged from 3 to 10 (average score = 5.42). Of the 12 articles that investigated ncRNAs as biomarkers, none included a validation cohort. Selective reporting of the sensitivity, specificity, and receiver operating curves was common. Conclusions: Although ncRNAs appear to be good candidates as biomarkers for predicting treatment response and therapeutics for sarcoma, their differential expression across tissues complicates their application. Further research regarding their potential for inhibiting or activating these regulatory molecules to reverse treatment resistance may be useful. Funding: This study’s literature retrieval was supported financially by the 345 Talent Project of Shengjing Hospital of China Medical University (M0949 to Tao Zhang).https://elifesciences.org/articles/79655sarcomanon-coding RNAsdrug resistanceradioresistancebiomarker |
| spellingShingle | Huan-Huan Chen Tie-Ning Zhang Fang-Yuan Zhang Tao Zhang Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review eLife sarcoma non-coding RNAs drug resistance radioresistance biomarker |
| title | Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review |
| title_full | Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review |
| title_fullStr | Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review |
| title_full_unstemmed | Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review |
| title_short | Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review |
| title_sort | non coding rnas in drug and radiation resistance of bone and soft tissue sarcoma a systematic review |
| topic | sarcoma non-coding RNAs drug resistance radioresistance biomarker |
| url | https://elifesciences.org/articles/79655 |
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