Renal AA-amyloidosis in intravenous drug users – a role for HIV-infection?
<p>Abstract</p> <p>Background</p> <p>Chronic renal disease is a serious complication of long-term intravenous drug use (IVDU). Recent reports have postulated a changing pattern of underlying nephropathy over the last decades.</p> <p>Methods</p> <p&g...
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| Format: | Article |
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BMC
2012-11-01
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| Series: | BMC Nephrology |
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| Online Access: | http://www.biomedcentral.com/1471-2369/13/151 |
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| author | Jung Oliver Haack Hans Buettner Maike Betz Christoph Stephan Christoph Gruetzmacher Peter Amann Kerstin Bickel Markus |
| author_facet | Jung Oliver Haack Hans Buettner Maike Betz Christoph Stephan Christoph Gruetzmacher Peter Amann Kerstin Bickel Markus |
| author_sort | Jung Oliver |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Chronic renal disease is a serious complication of long-term intravenous drug use (IVDU). Recent reports have postulated a changing pattern of underlying nephropathy over the last decades.</p> <p>Methods</p> <p>Retrospective investigation including all patients with prior or present IVDU that underwent renal biopsy because of chronic kidney disease between 01.04.2002 and 31.03.2012 in the city of Frankfurt/Main, Germany.</p> <p>Results</p> <p>Twenty four patients with IVDU underwent renal biopsy because of progressive chronic kidney disease or proteinuria. Renal AA-amyloidosis was the predominant cause of renal failure in 50% of patients. Membranoproliferative glomerulonephritis (GN) was the second most common cause found in 21%. Patients with AA-amyloidosis were more likely to be HIV infected (67 vs.17%; p=0.036) and tended to have a higher rate of repeated systemic infections (92 vs. 50%; p=0.069). Patients with AA-amyloidosis presented with progressive renal disease and nephrotic-range proteinuria but most patients had no peripheral edema or systemic hypertension. Development of proteinuria preceded the decline of GFR for approximately 1–2 years.</p> <p>Conclusions</p> <p>AA-amyloidosis was the predominant cause of progressive renal disease in the last 10 years in patients with IVDU. The highest rate of AA-amyloidosis observed was seen in HIV infected patients with IVDU. We speculate that chronic HIV-infection as well as the associated immunosuppression might promote development of AA-amyloidosis by increasing frequency and duration of infections acquired by IVDU.</p> |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-18T06:32:27Z |
| publishDate | 2012-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-dec06fb75e124229866836e1ac42bef22022-12-21T21:17:53ZengBMCBMC Nephrology1471-23692012-11-0113115110.1186/1471-2369-13-151Renal AA-amyloidosis in intravenous drug users – a role for HIV-infection?Jung OliverHaack HansBuettner MaikeBetz ChristophStephan ChristophGruetzmacher PeterAmann KerstinBickel Markus<p>Abstract</p> <p>Background</p> <p>Chronic renal disease is a serious complication of long-term intravenous drug use (IVDU). Recent reports have postulated a changing pattern of underlying nephropathy over the last decades.</p> <p>Methods</p> <p>Retrospective investigation including all patients with prior or present IVDU that underwent renal biopsy because of chronic kidney disease between 01.04.2002 and 31.03.2012 in the city of Frankfurt/Main, Germany.</p> <p>Results</p> <p>Twenty four patients with IVDU underwent renal biopsy because of progressive chronic kidney disease or proteinuria. Renal AA-amyloidosis was the predominant cause of renal failure in 50% of patients. Membranoproliferative glomerulonephritis (GN) was the second most common cause found in 21%. Patients with AA-amyloidosis were more likely to be HIV infected (67 vs.17%; p=0.036) and tended to have a higher rate of repeated systemic infections (92 vs. 50%; p=0.069). Patients with AA-amyloidosis presented with progressive renal disease and nephrotic-range proteinuria but most patients had no peripheral edema or systemic hypertension. Development of proteinuria preceded the decline of GFR for approximately 1–2 years.</p> <p>Conclusions</p> <p>AA-amyloidosis was the predominant cause of progressive renal disease in the last 10 years in patients with IVDU. The highest rate of AA-amyloidosis observed was seen in HIV infected patients with IVDU. We speculate that chronic HIV-infection as well as the associated immunosuppression might promote development of AA-amyloidosis by increasing frequency and duration of infections acquired by IVDU.</p>http://www.biomedcentral.com/1471-2369/13/151AA-amylodosisIVDUChronic kidney diseaseHIV |
| spellingShingle | Jung Oliver Haack Hans Buettner Maike Betz Christoph Stephan Christoph Gruetzmacher Peter Amann Kerstin Bickel Markus Renal AA-amyloidosis in intravenous drug users – a role for HIV-infection? BMC Nephrology AA-amylodosis IVDU Chronic kidney disease HIV |
| title | Renal AA-amyloidosis in intravenous drug users – a role for HIV-infection? |
| title_full | Renal AA-amyloidosis in intravenous drug users – a role for HIV-infection? |
| title_fullStr | Renal AA-amyloidosis in intravenous drug users – a role for HIV-infection? |
| title_full_unstemmed | Renal AA-amyloidosis in intravenous drug users – a role for HIV-infection? |
| title_short | Renal AA-amyloidosis in intravenous drug users – a role for HIV-infection? |
| title_sort | renal aa amyloidosis in intravenous drug users a role for hiv infection |
| topic | AA-amylodosis IVDU Chronic kidney disease HIV |
| url | http://www.biomedcentral.com/1471-2369/13/151 |
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