Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer.

Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer.

The CD44 transmembrane glycoproteins play multifaceted roles in tumor progression and metastasis. CD44 expression has also been associated with stem-like breast cancer cells. Hypoxia commonly occurs in tumors and is a major cause of radiation and chemo-resistance. Hypoxia is known to inhibit differe...

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Bibliographic Details
Main Authors: Balaji Krishnamachary, Marie-France Penet, Sridhar Nimmagadda, Yelena Mironchik, Venu Raman, Meiyappan Solaiyappan, Gregg L Semenza, Martin G Pomper, Zaver M Bhujwalla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3429433?pdf=render

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