Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5
<b><i>Background:</i></b> Low bone mass is common in malnourished patients with chronic kidney disease (CKD) and can lead to a higher risk of fractures. Elderly and CKD patients have the same risk factors for protein-energy wasting, sarcopenia, and osteoporosis. Here, we inve...
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MDPI AG
2023-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/7/1680 |
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| author | Byoung-Geun Han Daewoo Pak Jun Young Lee Jae-Seok Kim Jae-Won Yang Seongyup Kim |
| author_facet | Byoung-Geun Han Daewoo Pak Jun Young Lee Jae-Seok Kim Jae-Won Yang Seongyup Kim |
| author_sort | Byoung-Geun Han |
| collection | DOAJ |
| description | <b><i>Background:</i></b> Low bone mass is common in malnourished patients with chronic kidney disease (CKD) and can lead to a higher risk of fractures. Elderly and CKD patients have the same risk factors for protein-energy wasting, sarcopenia, and osteoporosis. Here, we investigated the association between phase angle (PhA) and bone mineral density (BMD) in dialysis-naïve patients with CKD stage 5 (CKD5) and identified a statistical relationship between PhA and age, which affects bone density. <b><i>Methods:</i></b> Bio-impedance spectroscopy for evaluating body composition and PhA and dual-energy X-ray absorptiometry for determining the BMD were simultaneously performed in 167 consecutive patients (mean age, 59.65 ± 13.98 years; women, 40.1%). Two-way analysis of variance (ANOVA) was conducted to assess the potential interaction effect of PhA and age on femoral neck BMD (FN-BMD). <b><i>Results:</i></b> Our results showed that PhA and age were independently associated with FN-BMD and T-score in multiple linear regressions analyses. A significant interaction effect of PhA and age on FN-BMD was found on two-way ANOVA (<i>p</i> = 0.028). The average BMD values for the first and second tertiles of the PhA were higher in the young versus elderly group, whereas patients in the elderly group had higher BMD in the third tertiles. <b><i>Conclusions:</i></b> A relationship was noted between PhA and BMD in patients with advanced-stage CKD. The effect of PhA level on FN-BMD differed between elderly and young patients. Our study suggested that higher PhA levels could be a marker explaining the maintenance of good bone health in elderly patients with CKD5. Further longitudinal analyses are needed to determine whether PhA predicts the risk of CKD-MBD-related fractures during CKD progression. |
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| last_indexed | 2024-03-11T05:28:15Z |
| publishDate | 2023-03-01 |
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| series | Nutrients |
| spelling | doaj.art-dec2901f8ac642f38bd760d66c22b7ee2023-11-17T17:20:30ZengMDPI AGNutrients2072-66432023-03-01157168010.3390/nu15071680Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5Byoung-Geun Han0Daewoo Pak1Jun Young Lee2Jae-Seok Kim3Jae-Won Yang4Seongyup Kim5Department of Nephrology, Yonsei University Wonju College of Medicine, Wonju 26426, Kang-won, Republic of KoreaDivision of Data Science, Yonsei University, Wonju 26493, Kang-won, Republic of KoreaDepartment of Nephrology, Yonsei University Wonju College of Medicine, Wonju 26426, Kang-won, Republic of KoreaDepartment of Nephrology, Yonsei University Wonju College of Medicine, Wonju 26426, Kang-won, Republic of KoreaDepartment of Nephrology, Yonsei University Wonju College of Medicine, Wonju 26426, Kang-won, Republic of KoreaDepartment of Surgery, Yonsei University Wonju College of Medicine, Wonju 26426, Kang-won, Republic of Korea<b><i>Background:</i></b> Low bone mass is common in malnourished patients with chronic kidney disease (CKD) and can lead to a higher risk of fractures. Elderly and CKD patients have the same risk factors for protein-energy wasting, sarcopenia, and osteoporosis. Here, we investigated the association between phase angle (PhA) and bone mineral density (BMD) in dialysis-naïve patients with CKD stage 5 (CKD5) and identified a statistical relationship between PhA and age, which affects bone density. <b><i>Methods:</i></b> Bio-impedance spectroscopy for evaluating body composition and PhA and dual-energy X-ray absorptiometry for determining the BMD were simultaneously performed in 167 consecutive patients (mean age, 59.65 ± 13.98 years; women, 40.1%). Two-way analysis of variance (ANOVA) was conducted to assess the potential interaction effect of PhA and age on femoral neck BMD (FN-BMD). <b><i>Results:</i></b> Our results showed that PhA and age were independently associated with FN-BMD and T-score in multiple linear regressions analyses. A significant interaction effect of PhA and age on FN-BMD was found on two-way ANOVA (<i>p</i> = 0.028). The average BMD values for the first and second tertiles of the PhA were higher in the young versus elderly group, whereas patients in the elderly group had higher BMD in the third tertiles. <b><i>Conclusions:</i></b> A relationship was noted between PhA and BMD in patients with advanced-stage CKD. The effect of PhA level on FN-BMD differed between elderly and young patients. Our study suggested that higher PhA levels could be a marker explaining the maintenance of good bone health in elderly patients with CKD5. Further longitudinal analyses are needed to determine whether PhA predicts the risk of CKD-MBD-related fractures during CKD progression.https://www.mdpi.com/2072-6643/15/7/1680agingbody compositionbone mineral densitychronic kidney diseaseimpedance |
| spellingShingle | Byoung-Geun Han Daewoo Pak Jun Young Lee Jae-Seok Kim Jae-Won Yang Seongyup Kim Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5 Nutrients aging body composition bone mineral density chronic kidney disease impedance |
| title | Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5 |
| title_full | Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5 |
| title_fullStr | Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5 |
| title_full_unstemmed | Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5 |
| title_short | Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5 |
| title_sort | interaction effect of phase angle and age on femoral neck bone mineral density in patients with non dialysis chronic kidney disease stage 5 |
| topic | aging body composition bone mineral density chronic kidney disease impedance |
| url | https://www.mdpi.com/2072-6643/15/7/1680 |
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