Augmented reduction in colonic inflammatory markers of dextran sulfate sodium-induced colitis with a combination of 5-aminosalicylic acid and AD-lico™ from Glycyrrhiza inflata
The primary aim of this study was to determine whether the oral administration of AD-lico™, a functional extract from Glycyrrhiza inflata in combination with 5-aminosalicylic acid (5-ASA) could ameliorate the inflammatory symptoms in dextran sulfate sodium (DSS)-induced colitis in rodents. This DSS...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-05-01
|
| Series: | Animal Cells and Systems |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19768354.2018.1476409 |
| _version_ | 1819169831416496128 |
|---|---|
| author | Jaeyoung Cho Hyuck-Se Kweon Sung-Oh Huh Ali Sadra |
| author_facet | Jaeyoung Cho Hyuck-Se Kweon Sung-Oh Huh Ali Sadra |
| author_sort | Jaeyoung Cho |
| collection | DOAJ |
| description | The primary aim of this study was to determine whether the oral administration of AD-lico™, a functional extract from Glycyrrhiza inflata in combination with 5-aminosalicylic acid (5-ASA) could ameliorate the inflammatory symptoms in dextran sulfate sodium (DSS)-induced colitis in rodents. This DSS rodent model is used to study drug candidates for colitis, as part of the spectrum of diseases falling under the inflammatory bowel disease (IBD) category. Here, with oral AD-lico™ administration, there was a substantial disruption of the colonic architectural changes due to DSS and a significant reduction in colonic myeloperoxidase (MPO) activity, a marker of colitis. In the same samples, there were also reduced levels of colonic and serum IL-6 in the oral AD-lico™ treated rats. This study also addressed the possible mechanisms for AD-lico™ mediated changes on colonic inflammation markers. These included the observations that AD-lico™ dampened the IL-6 proinflammatory-signaling pathway in THP-1 human monocytic cells and reduced the TNFα-mediated upregulation of surface adhesion molecule ICAM-1 in human umbilical vein endothelial cells (HUVECs). Finally, it was shown that AD-lico™ could be combined with 5-ASA in reducing the inflammatory markers for colorectal sites affected by colitis, a first study of its kind for a combination therapy. |
| first_indexed | 2024-12-22T19:25:45Z |
| format | Article |
| id | doaj.art-dec568a2f4bc44bfac4f949821e0559d |
| institution | Directory Open Access Journal |
| issn | 1976-8354 2151-2485 |
| language | English |
| last_indexed | 2024-12-22T19:25:45Z |
| publishDate | 2018-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Cells and Systems |
| spelling | doaj.art-dec568a2f4bc44bfac4f949821e0559d2022-12-21T18:15:15ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852018-05-0122318919610.1080/19768354.2018.14764091476409Augmented reduction in colonic inflammatory markers of dextran sulfate sodium-induced colitis with a combination of 5-aminosalicylic acid and AD-lico™ from Glycyrrhiza inflataJaeyoung Cho0Hyuck-Se Kweon1Sung-Oh Huh2Ali Sadra3Unites IncSynergyBioHallym UniversityHallym UniversityThe primary aim of this study was to determine whether the oral administration of AD-lico™, a functional extract from Glycyrrhiza inflata in combination with 5-aminosalicylic acid (5-ASA) could ameliorate the inflammatory symptoms in dextran sulfate sodium (DSS)-induced colitis in rodents. This DSS rodent model is used to study drug candidates for colitis, as part of the spectrum of diseases falling under the inflammatory bowel disease (IBD) category. Here, with oral AD-lico™ administration, there was a substantial disruption of the colonic architectural changes due to DSS and a significant reduction in colonic myeloperoxidase (MPO) activity, a marker of colitis. In the same samples, there were also reduced levels of colonic and serum IL-6 in the oral AD-lico™ treated rats. This study also addressed the possible mechanisms for AD-lico™ mediated changes on colonic inflammation markers. These included the observations that AD-lico™ dampened the IL-6 proinflammatory-signaling pathway in THP-1 human monocytic cells and reduced the TNFα-mediated upregulation of surface adhesion molecule ICAM-1 in human umbilical vein endothelial cells (HUVECs). Finally, it was shown that AD-lico™ could be combined with 5-ASA in reducing the inflammatory markers for colorectal sites affected by colitis, a first study of its kind for a combination therapy.http://dx.doi.org/10.1080/19768354.2018.1476409Dextran sulfate sodiuminflammationinflammatory bowel diseasecolitisinterleukin-6tumor necrosis factor |
| spellingShingle | Jaeyoung Cho Hyuck-Se Kweon Sung-Oh Huh Ali Sadra Augmented reduction in colonic inflammatory markers of dextran sulfate sodium-induced colitis with a combination of 5-aminosalicylic acid and AD-lico™ from Glycyrrhiza inflata Animal Cells and Systems Dextran sulfate sodium inflammation inflammatory bowel disease colitis interleukin-6 tumor necrosis factor |
| title | Augmented reduction in colonic inflammatory markers of dextran sulfate sodium-induced colitis with a combination of 5-aminosalicylic acid and AD-lico™ from Glycyrrhiza inflata |
| title_full | Augmented reduction in colonic inflammatory markers of dextran sulfate sodium-induced colitis with a combination of 5-aminosalicylic acid and AD-lico™ from Glycyrrhiza inflata |
| title_fullStr | Augmented reduction in colonic inflammatory markers of dextran sulfate sodium-induced colitis with a combination of 5-aminosalicylic acid and AD-lico™ from Glycyrrhiza inflata |
| title_full_unstemmed | Augmented reduction in colonic inflammatory markers of dextran sulfate sodium-induced colitis with a combination of 5-aminosalicylic acid and AD-lico™ from Glycyrrhiza inflata |
| title_short | Augmented reduction in colonic inflammatory markers of dextran sulfate sodium-induced colitis with a combination of 5-aminosalicylic acid and AD-lico™ from Glycyrrhiza inflata |
| title_sort | augmented reduction in colonic inflammatory markers of dextran sulfate sodium induced colitis with a combination of 5 aminosalicylic acid and ad lico™ from glycyrrhiza inflata |
| topic | Dextran sulfate sodium inflammation inflammatory bowel disease colitis interleukin-6 tumor necrosis factor |
| url | http://dx.doi.org/10.1080/19768354.2018.1476409 |
| work_keys_str_mv | AT jaeyoungcho augmentedreductionincolonicinflammatorymarkersofdextransulfatesodiuminducedcolitiswithacombinationof5aminosalicylicacidandadlicofromglycyrrhizainflata AT hyucksekweon augmentedreductionincolonicinflammatorymarkersofdextransulfatesodiuminducedcolitiswithacombinationof5aminosalicylicacidandadlicofromglycyrrhizainflata AT sungohhuh augmentedreductionincolonicinflammatorymarkersofdextransulfatesodiuminducedcolitiswithacombinationof5aminosalicylicacidandadlicofromglycyrrhizainflata AT alisadra augmentedreductionincolonicinflammatorymarkersofdextransulfatesodiuminducedcolitiswithacombinationof5aminosalicylicacidandadlicofromglycyrrhizainflata |