What do patients consider to be the most important outcomes for effectiveness studies on migraine treatment? Results of a Delphi study.
BACKGROUND: The outcome measures most frequently used in studies on the effectiveness of migraine treatment are whether the patient is free of pain, nausea, and free of photophobia/phonophobia within two hours. However, no patient-centred outcome measures are available. Therefore, we performed an on...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4059644?pdf=render |
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| author | Antonia F H Smelt Mark A Louter Dennis A Kies Jeanet W Blom Gisela M Terwindt Geert J M G van der Heijden Véronique De Gucht Michel D Ferrari Willem J J Assendelft |
| author_facet | Antonia F H Smelt Mark A Louter Dennis A Kies Jeanet W Blom Gisela M Terwindt Geert J M G van der Heijden Véronique De Gucht Michel D Ferrari Willem J J Assendelft |
| author_sort | Antonia F H Smelt |
| collection | DOAJ |
| description | BACKGROUND: The outcome measures most frequently used in studies on the effectiveness of migraine treatment are whether the patient is free of pain, nausea, and free of photophobia/phonophobia within two hours. However, no patient-centred outcome measures are available. Therefore, we performed an online Delphi procedure to compile a list of outcome measures deemed most important to migraine patients. METHODS: From a large database of migraine patients, we randomly selected 150 males and 150 females patients. We asked the open-ended question: 'If a new medicine was developed for migraine attacks, what would you wish the effect of this medication to be?' In the second and third rounds, we presented the answers of the first round and asked the patients to rate the importance of each item. RESULTS: The initial response rate was 56% (n = 169). In the subsequent rounds the response rates were 90% (n = 152), and 97% (n = 147), respectively. Patients wanted their attack medication to treat the headache within 30 min, to prevent the attack from getting worse, to ensure they could function properly within 1 h, and prevent the recurrence of symptoms during the same day. CONCLUSIONS: The currently used outcome measures in migraine research do not sufficiently reflect the wishes of patients. Patients want the medication to work faster, to take away pain at an earlier stage, to make them able to function properly quickly, and to prevent recurrence. These aspects should be considered in future evaluation of new attack medication for migraine. |
| first_indexed | 2024-12-20T07:20:53Z |
| format | Article |
| id | doaj.art-dec72e422cf1403dba4964075c256d5d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T07:20:53Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dec72e422cf1403dba4964075c256d5d2022-12-21T19:48:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e9893310.1371/journal.pone.0098933What do patients consider to be the most important outcomes for effectiveness studies on migraine treatment? Results of a Delphi study.Antonia F H SmeltMark A LouterDennis A KiesJeanet W BlomGisela M TerwindtGeert J M G van der HeijdenVéronique De GuchtMichel D FerrariWillem J J AssendelftBACKGROUND: The outcome measures most frequently used in studies on the effectiveness of migraine treatment are whether the patient is free of pain, nausea, and free of photophobia/phonophobia within two hours. However, no patient-centred outcome measures are available. Therefore, we performed an online Delphi procedure to compile a list of outcome measures deemed most important to migraine patients. METHODS: From a large database of migraine patients, we randomly selected 150 males and 150 females patients. We asked the open-ended question: 'If a new medicine was developed for migraine attacks, what would you wish the effect of this medication to be?' In the second and third rounds, we presented the answers of the first round and asked the patients to rate the importance of each item. RESULTS: The initial response rate was 56% (n = 169). In the subsequent rounds the response rates were 90% (n = 152), and 97% (n = 147), respectively. Patients wanted their attack medication to treat the headache within 30 min, to prevent the attack from getting worse, to ensure they could function properly within 1 h, and prevent the recurrence of symptoms during the same day. CONCLUSIONS: The currently used outcome measures in migraine research do not sufficiently reflect the wishes of patients. Patients want the medication to work faster, to take away pain at an earlier stage, to make them able to function properly quickly, and to prevent recurrence. These aspects should be considered in future evaluation of new attack medication for migraine.http://europepmc.org/articles/PMC4059644?pdf=render |
| spellingShingle | Antonia F H Smelt Mark A Louter Dennis A Kies Jeanet W Blom Gisela M Terwindt Geert J M G van der Heijden Véronique De Gucht Michel D Ferrari Willem J J Assendelft What do patients consider to be the most important outcomes for effectiveness studies on migraine treatment? Results of a Delphi study. PLoS ONE |
| title | What do patients consider to be the most important outcomes for effectiveness studies on migraine treatment? Results of a Delphi study. |
| title_full | What do patients consider to be the most important outcomes for effectiveness studies on migraine treatment? Results of a Delphi study. |
| title_fullStr | What do patients consider to be the most important outcomes for effectiveness studies on migraine treatment? Results of a Delphi study. |
| title_full_unstemmed | What do patients consider to be the most important outcomes for effectiveness studies on migraine treatment? Results of a Delphi study. |
| title_short | What do patients consider to be the most important outcomes for effectiveness studies on migraine treatment? Results of a Delphi study. |
| title_sort | what do patients consider to be the most important outcomes for effectiveness studies on migraine treatment results of a delphi study |
| url | http://europepmc.org/articles/PMC4059644?pdf=render |
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