Distribusi Genotipe dan Subtipe Virus Hepatitis B pada Penderita Hepatitis B Kronik di Pekanbaru
Genetic variance of hepatitis B virus (HBV) may influence the clinical manifestation, development of hepatocellular carcinoma (HCC), and response to antiviral treatment. This was analytic cross-sectional study which aimed to investigate the distribution of HBV genotypes and subtypes among different...
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| Format: | Article |
| Language: | English |
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Universitas Padjajaran
2011-09-01
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| Series: | Majalah Kedokteran Bandung |
| Subjects: | |
| Online Access: | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/54 |
| _version_ | 1811266854354681856 |
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| author | Arfianti Andi Zainal Fauzia Andrini Rita Endriani |
| author_facet | Arfianti Andi Zainal Fauzia Andrini Rita Endriani |
| author_sort | Arfianti |
| collection | DOAJ |
| description | Genetic variance of hepatitis B virus (HBV) may influence the clinical manifestation, development of hepatocellular carcinoma (HCC), and response to antiviral treatment. This was analytic cross-sectional study which aimed to investigate the distribution of HBV genotypes and subtypes among different clinical status of chronic hepatitis B in Pekanbaru. A total of fifty-two of sera from chronic hepatitis B patients in Pekanbaru was collected from March to August 2009. Statistical analysis was performed by using Fisher test. HBV genotypes were examined based on homology of S gene from this study with those of GenBank database. Of these subjects, 31 (60%) and 21 (40%) were infected by genotype C and B, respectively. Based on clinical manifestation, genotype C was predominantly found among HBsAg-positive blood donors (7/10 patients) and liver cirrhosis (7/10 patients), whereas genotype B and C were comparable among chronic hepatitis B active and hepatocellular carcinoma patients. Subtype adr (60%) was the most prevalent, followed by subtype adw (38%) and subtype ayw (2%). There were no significant difference in the distribution of HBV genotypes and subtypes among diverse clinical manifestation of HBV infection. However, genotype C was predominantly detected among cirrhotic-HCC (8/9 patients) , while genotype B was mostly identified among non cirrhotic-HCC (8/11 patients) (p=0.01). In conclusion, HBV genotype may be associated with the pathogenesis of cirrhotic and noncirrhotic-HCC. |
| first_indexed | 2024-04-12T20:50:47Z |
| format | Article |
| id | doaj.art-dec7bc5009c6444ebcf651808a9c7445 |
| institution | Directory Open Access Journal |
| issn | 0126-074X 2338-6223 |
| language | English |
| last_indexed | 2024-04-12T20:50:47Z |
| publishDate | 2011-09-01 |
| publisher | Universitas Padjajaran |
| record_format | Article |
| series | Majalah Kedokteran Bandung |
| spelling | doaj.art-dec7bc5009c6444ebcf651808a9c74452022-12-22T03:17:09ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X2338-62232011-09-0143310511110.15395/mkb.v43n3.54Distribusi Genotipe dan Subtipe Virus Hepatitis B pada Penderita Hepatitis B Kronik di PekanbaruArfianti0Andi Zainal1Fauzia Andrini2Rita Endriani3Bagian Biologi Kedokteran Fakultas Kedokteran Universitas RiauBagian Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Riau-RSUD Arifin Ahmad PekanbaruBagian Mikrobiologi Fakultas Kedokteran Universitas RiauBagian Mikrobiologi Fakultas Kedokteran Universitas RiauGenetic variance of hepatitis B virus (HBV) may influence the clinical manifestation, development of hepatocellular carcinoma (HCC), and response to antiviral treatment. This was analytic cross-sectional study which aimed to investigate the distribution of HBV genotypes and subtypes among different clinical status of chronic hepatitis B in Pekanbaru. A total of fifty-two of sera from chronic hepatitis B patients in Pekanbaru was collected from March to August 2009. Statistical analysis was performed by using Fisher test. HBV genotypes were examined based on homology of S gene from this study with those of GenBank database. Of these subjects, 31 (60%) and 21 (40%) were infected by genotype C and B, respectively. Based on clinical manifestation, genotype C was predominantly found among HBsAg-positive blood donors (7/10 patients) and liver cirrhosis (7/10 patients), whereas genotype B and C were comparable among chronic hepatitis B active and hepatocellular carcinoma patients. Subtype adr (60%) was the most prevalent, followed by subtype adw (38%) and subtype ayw (2%). There were no significant difference in the distribution of HBV genotypes and subtypes among diverse clinical manifestation of HBV infection. However, genotype C was predominantly detected among cirrhotic-HCC (8/9 patients) , while genotype B was mostly identified among non cirrhotic-HCC (8/11 patients) (p=0.01). In conclusion, HBV genotype may be associated with the pathogenesis of cirrhotic and noncirrhotic-HCC.http://journal.fk.unpad.ac.id/index.php/mkb/article/view/54Chronic hepatitis Bgenotypehepatocellular carcinomaliver cirrhosissubtype |
| spellingShingle | Arfianti Andi Zainal Fauzia Andrini Rita Endriani Distribusi Genotipe dan Subtipe Virus Hepatitis B pada Penderita Hepatitis B Kronik di Pekanbaru Majalah Kedokteran Bandung Chronic hepatitis B genotype hepatocellular carcinoma liver cirrhosis subtype |
| title | Distribusi Genotipe dan Subtipe Virus Hepatitis B pada Penderita Hepatitis B Kronik di Pekanbaru |
| title_full | Distribusi Genotipe dan Subtipe Virus Hepatitis B pada Penderita Hepatitis B Kronik di Pekanbaru |
| title_fullStr | Distribusi Genotipe dan Subtipe Virus Hepatitis B pada Penderita Hepatitis B Kronik di Pekanbaru |
| title_full_unstemmed | Distribusi Genotipe dan Subtipe Virus Hepatitis B pada Penderita Hepatitis B Kronik di Pekanbaru |
| title_short | Distribusi Genotipe dan Subtipe Virus Hepatitis B pada Penderita Hepatitis B Kronik di Pekanbaru |
| title_sort | distribusi genotipe dan subtipe virus hepatitis b pada penderita hepatitis b kronik di pekanbaru |
| topic | Chronic hepatitis B genotype hepatocellular carcinoma liver cirrhosis subtype |
| url | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/54 |
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