Predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma.
OBJECTIVE:To determine the predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy (RT) for nasopharyngeal carcinoma (NPC). METHODS:The present study investigated 129 post-RT NPC patients. Carotid atherosclerotic parameters, such as carotid intima-media thickness, c...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4281159?pdf=render |
| _version_ | 1829115479842619392 |
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| author | Chuang Yuan Vincent W C Wu Shea Ping Yip Dora L W Kwong Michael Ying |
| author_facet | Chuang Yuan Vincent W C Wu Shea Ping Yip Dora L W Kwong Michael Ying |
| author_sort | Chuang Yuan |
| collection | DOAJ |
| description | OBJECTIVE:To determine the predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy (RT) for nasopharyngeal carcinoma (NPC). METHODS:The present study investigated 129 post-RT NPC patients. Carotid atherosclerotic parameters, such as carotid intima-media thickness, carotid arterial stiffness and carotid plaque burden (plaque score, the presence of plaque and ≥50% stenosis) were assessed using ultrasonography. The association between carotid atherosclerotic parameters and nine potential predictors, including age, gender, post-RT duration, radiation dose, chemotherapy, diabetes mellitus, hypertension, hypercholesterolemia, and smoking, were determined using multiple regression. The cutoff values of age, post-RT duration and number of cardiovascular risk factors for the presence of carotid plaque or ≥50% carotid stenosis were analyzed using receiver operating characteristic (ROC) curve analysis. Multiple testing was corrected using Benjamini-Hochberg false discovery rate. RESULTS:Age, post-RT duration and number of cardiovascular risk factors were significantly associated with carotid plaque burden (corrected P value, Pcor<0.05). Age of 44.5 years (sensitivity = 99.2% and specificity = 50%, Pcor<0.01) and post-RT duration of 8.5 years (sensitivity = 75.7% and specificity = 64.3%, Pcor<0.001) were the cutoff values for detecting carotid plaque, while post-RT duration of 13.5 years (sensitivity = 66.7% and specificity = 71.6%, Pcor<0.001) and 1.5 cardiovascular risk factors (sensitivity = 40.7% and specificity = 84.3%, Pcor<0.05) were the cutoff values for screening ≥50% carotid stenosis. CONCLUSIONS:Age, post-RT duration and number of cardiovascular risk factors are significant predictors of carotid atherosclerosis in post-RT NPC patients. Post-RT NPC patients, who are at least 45 years old, with post-RT duration of 9 years or above, and/or have ≥2 cardiovascular risk factors, are more susceptible to carotid atherosclerosis. |
| first_indexed | 2024-12-12T16:15:02Z |
| format | Article |
| id | doaj.art-dec983b8f3364d5dac21f11c5c316f63 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T16:15:02Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dec983b8f3364d5dac21f11c5c316f632022-12-22T00:19:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11628410.1371/journal.pone.0116284Predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma.Chuang YuanVincent W C WuShea Ping YipDora L W KwongMichael YingOBJECTIVE:To determine the predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy (RT) for nasopharyngeal carcinoma (NPC). METHODS:The present study investigated 129 post-RT NPC patients. Carotid atherosclerotic parameters, such as carotid intima-media thickness, carotid arterial stiffness and carotid plaque burden (plaque score, the presence of plaque and ≥50% stenosis) were assessed using ultrasonography. The association between carotid atherosclerotic parameters and nine potential predictors, including age, gender, post-RT duration, radiation dose, chemotherapy, diabetes mellitus, hypertension, hypercholesterolemia, and smoking, were determined using multiple regression. The cutoff values of age, post-RT duration and number of cardiovascular risk factors for the presence of carotid plaque or ≥50% carotid stenosis were analyzed using receiver operating characteristic (ROC) curve analysis. Multiple testing was corrected using Benjamini-Hochberg false discovery rate. RESULTS:Age, post-RT duration and number of cardiovascular risk factors were significantly associated with carotid plaque burden (corrected P value, Pcor<0.05). Age of 44.5 years (sensitivity = 99.2% and specificity = 50%, Pcor<0.01) and post-RT duration of 8.5 years (sensitivity = 75.7% and specificity = 64.3%, Pcor<0.001) were the cutoff values for detecting carotid plaque, while post-RT duration of 13.5 years (sensitivity = 66.7% and specificity = 71.6%, Pcor<0.001) and 1.5 cardiovascular risk factors (sensitivity = 40.7% and specificity = 84.3%, Pcor<0.05) were the cutoff values for screening ≥50% carotid stenosis. CONCLUSIONS:Age, post-RT duration and number of cardiovascular risk factors are significant predictors of carotid atherosclerosis in post-RT NPC patients. Post-RT NPC patients, who are at least 45 years old, with post-RT duration of 9 years or above, and/or have ≥2 cardiovascular risk factors, are more susceptible to carotid atherosclerosis.http://europepmc.org/articles/PMC4281159?pdf=render |
| spellingShingle | Chuang Yuan Vincent W C Wu Shea Ping Yip Dora L W Kwong Michael Ying Predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma. PLoS ONE |
| title | Predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma. |
| title_full | Predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma. |
| title_fullStr | Predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma. |
| title_full_unstemmed | Predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma. |
| title_short | Predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma. |
| title_sort | predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma |
| url | http://europepmc.org/articles/PMC4281159?pdf=render |
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