Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition
Detecting Alzheimer’s disease from blood samples is challenging because amyloid β blood levels are lower than the ELISA detection limit. Here the authors capture amyloid β bound to circulating exosomes on a plasmonic nanosensor, followed by enzymatic amplification to improve detection sensitivity....
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09030-2 |
| _version_ | 1818855824409231360 |
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| author | Carine Z. J. Lim Yan Zhang Yu Chen Haitao Zhao Mary C. Stephenson Nicholas R. Y. Ho Yuan Chen Jaehoon Chung Anthonin Reilhac Tze Ping Loh Christopher L. H. Chen Huilin Shao |
| author_facet | Carine Z. J. Lim Yan Zhang Yu Chen Haitao Zhao Mary C. Stephenson Nicholas R. Y. Ho Yuan Chen Jaehoon Chung Anthonin Reilhac Tze Ping Loh Christopher L. H. Chen Huilin Shao |
| author_sort | Carine Z. J. Lim |
| collection | DOAJ |
| description | Detecting Alzheimer’s disease from blood samples is challenging because amyloid β blood levels are lower than the ELISA detection limit. Here the authors capture amyloid β bound to circulating exosomes on a plasmonic nanosensor, followed by enzymatic amplification to improve detection sensitivity. |
| first_indexed | 2024-12-19T08:14:44Z |
| format | Article |
| id | doaj.art-dec9dff033f84a82beaf5f86c984fcd5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:14:44Z |
| publishDate | 2019-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-dec9dff033f84a82beaf5f86c984fcd52022-12-21T20:29:32ZengNature PortfolioNature Communications2041-17232019-03-0110111110.1038/s41467-019-09030-2Subtyping of circulating exosome-bound amyloid β reflects brain plaque depositionCarine Z. J. Lim0Yan Zhang1Yu Chen2Haitao Zhao3Mary C. Stephenson4Nicholas R. Y. Ho5Yuan Chen6Jaehoon Chung7Anthonin Reilhac8Tze Ping Loh9Christopher L. H. Chen10Huilin Shao11Department of Biomedical Engineering, Faculty of Engineering, National University of SingaporeDepartment of Biomedical Engineering, Faculty of Engineering, National University of SingaporeInstitute of Microelectronics, Agency for Science, Technology and ResearchDepartment of Biomedical Engineering, Faculty of Engineering, National University of SingaporeClinical Imaging Research Center, National University of SingaporeBiomedical Institute for Global Health Research and Technology, National University of SingaporeDepartment of Biomedical Engineering, Faculty of Engineering, National University of SingaporeInstitute of Microelectronics, Agency for Science, Technology and ResearchClinical Imaging Research Center, National University of SingaporeBiomedical Institute for Global Health Research and Technology, National University of SingaporeMemory Ageing and Cognition Center, National University HospitalDepartment of Biomedical Engineering, Faculty of Engineering, National University of SingaporeDetecting Alzheimer’s disease from blood samples is challenging because amyloid β blood levels are lower than the ELISA detection limit. Here the authors capture amyloid β bound to circulating exosomes on a plasmonic nanosensor, followed by enzymatic amplification to improve detection sensitivity.https://doi.org/10.1038/s41467-019-09030-2 |
| spellingShingle | Carine Z. J. Lim Yan Zhang Yu Chen Haitao Zhao Mary C. Stephenson Nicholas R. Y. Ho Yuan Chen Jaehoon Chung Anthonin Reilhac Tze Ping Loh Christopher L. H. Chen Huilin Shao Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition Nature Communications |
| title | Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition |
| title_full | Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition |
| title_fullStr | Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition |
| title_full_unstemmed | Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition |
| title_short | Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition |
| title_sort | subtyping of circulating exosome bound amyloid β reflects brain plaque deposition |
| url | https://doi.org/10.1038/s41467-019-09030-2 |
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