Effect of BMI on the value of serum progesterone to predict clinical pregnancy outcome in IVF/ICSI cycles: a retrospective cohort study
BackgroundNumerous research have investigated the predictor role of progesterone (P) level on the human Chorionic Gonadotropin (hCG) trigger day of assisted reproductive technology (ART) outcomes. However, the relationship of progesterone levels on hCG day to clinical pregnancy outcomes in IVF/ICSI...
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1162302/full |
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| author | Zhaoyang Shen Zhaoyang Shen Zhaoyang Shen Xiaoyan Luo Xiaoyan Luo Xiaoyan Luo Jianming Xu Jianming Xu Jianming Xu Yuqing Jiang Yuqing Jiang Yuqing Jiang Wenhui Chen Wenhui Chen Wenhui Chen Qingling Yang Qingling Yang Qingling Yang Yingpu Sun Yingpu Sun Yingpu Sun |
| author_facet | Zhaoyang Shen Zhaoyang Shen Zhaoyang Shen Xiaoyan Luo Xiaoyan Luo Xiaoyan Luo Jianming Xu Jianming Xu Jianming Xu Yuqing Jiang Yuqing Jiang Yuqing Jiang Wenhui Chen Wenhui Chen Wenhui Chen Qingling Yang Qingling Yang Qingling Yang Yingpu Sun Yingpu Sun Yingpu Sun |
| author_sort | Zhaoyang Shen |
| collection | DOAJ |
| description | BackgroundNumerous research have investigated the predictor role of progesterone (P) level on the human Chorionic Gonadotropin (hCG) trigger day of assisted reproductive technology (ART) outcomes. However, the relationship of progesterone levels on hCG day to clinical pregnancy outcomes in IVF/ICSI cycles for patients with different BMI groups is still elusive. This study aimed to investigate the effects of progesterone elevation on triggering day on clinical pregnancy rate (CPR) of IVF/ICSI cycles in patients with different female BMI.MethodsWe conducted a retrospective cohort study included 6982 normal-weight parents (18.5Kg/m2≤BMI<25Kg/m2) and 2628 overweight/obese patients (BMI≥25Kg/m2) who underwent fresh day 3 cleavage embryo transfer (ET) in IVF/ICSI cycles utilizing GnRH agonist to control ovarian stimulation.ResultsThe interaction between BMI and P level on triggering day on CPRs was significant (p<0.001). The average level of serum P was reduced with the increase in maternal BMI. Serum P adversely affected CPR in distinct BMI groups. In the normal weight group, CPRs were decreasedas serum P concentrations gradually increased (p<0.001 for overall trend). The CPRs (lower than 65.8%) of progesterone level > 1.00 ng/ml on triggering day were significantly lower than that (72.4%) of progesterone level <0.5 ng/ml. In the overweight/obese group, CPRs showed a decrease statistically with progesterone levels of ≥2.00 ng/ml compared to progesterone levels of <0.5 ng/ml (51.0% VS. 64.9%, p=0.016). After adjusting for confounders, progesterone elevation (PE) negatively correlated with CPRs only in the normal weight group (OR: 0.755 [0.677–0.841], p<0.001), not in the overweight/obese group (p=0.063).ConclusionWomen with higher BMI exhibited a lower progesterone level on triggering day. Additionally, PE on hCG day is related to decreased CPRs in GnRH agonist IVF/ICSI cycles with cleavage embryo transfers regardless of women’s BMI level (normal weight VS. overweight/obesity). |
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| spelling | doaj.art-decb9d484a384ba4b8acd807fdeac7c92023-04-19T05:25:05ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-04-011410.3389/fendo.2023.11623021162302Effect of BMI on the value of serum progesterone to predict clinical pregnancy outcome in IVF/ICSI cycles: a retrospective cohort studyZhaoyang Shen0Zhaoyang Shen1Zhaoyang Shen2Xiaoyan Luo3Xiaoyan Luo4Xiaoyan Luo5Jianming Xu6Jianming Xu7Jianming Xu8Yuqing Jiang9Yuqing Jiang10Yuqing Jiang11Wenhui Chen12Wenhui Chen13Wenhui Chen14Qingling Yang15Qingling Yang16Qingling Yang17Yingpu Sun18Yingpu Sun19Yingpu Sun20Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaBackgroundNumerous research have investigated the predictor role of progesterone (P) level on the human Chorionic Gonadotropin (hCG) trigger day of assisted reproductive technology (ART) outcomes. However, the relationship of progesterone levels on hCG day to clinical pregnancy outcomes in IVF/ICSI cycles for patients with different BMI groups is still elusive. This study aimed to investigate the effects of progesterone elevation on triggering day on clinical pregnancy rate (CPR) of IVF/ICSI cycles in patients with different female BMI.MethodsWe conducted a retrospective cohort study included 6982 normal-weight parents (18.5Kg/m2≤BMI<25Kg/m2) and 2628 overweight/obese patients (BMI≥25Kg/m2) who underwent fresh day 3 cleavage embryo transfer (ET) in IVF/ICSI cycles utilizing GnRH agonist to control ovarian stimulation.ResultsThe interaction between BMI and P level on triggering day on CPRs was significant (p<0.001). The average level of serum P was reduced with the increase in maternal BMI. Serum P adversely affected CPR in distinct BMI groups. In the normal weight group, CPRs were decreasedas serum P concentrations gradually increased (p<0.001 for overall trend). The CPRs (lower than 65.8%) of progesterone level > 1.00 ng/ml on triggering day were significantly lower than that (72.4%) of progesterone level <0.5 ng/ml. In the overweight/obese group, CPRs showed a decrease statistically with progesterone levels of ≥2.00 ng/ml compared to progesterone levels of <0.5 ng/ml (51.0% VS. 64.9%, p=0.016). After adjusting for confounders, progesterone elevation (PE) negatively correlated with CPRs only in the normal weight group (OR: 0.755 [0.677–0.841], p<0.001), not in the overweight/obese group (p=0.063).ConclusionWomen with higher BMI exhibited a lower progesterone level on triggering day. Additionally, PE on hCG day is related to decreased CPRs in GnRH agonist IVF/ICSI cycles with cleavage embryo transfers regardless of women’s BMI level (normal weight VS. overweight/obesity).https://www.frontiersin.org/articles/10.3389/fendo.2023.1162302/fullIVF/ICSIprogesteronehCGobesityclinical pregnancy |
| spellingShingle | Zhaoyang Shen Zhaoyang Shen Zhaoyang Shen Xiaoyan Luo Xiaoyan Luo Xiaoyan Luo Jianming Xu Jianming Xu Jianming Xu Yuqing Jiang Yuqing Jiang Yuqing Jiang Wenhui Chen Wenhui Chen Wenhui Chen Qingling Yang Qingling Yang Qingling Yang Yingpu Sun Yingpu Sun Yingpu Sun Effect of BMI on the value of serum progesterone to predict clinical pregnancy outcome in IVF/ICSI cycles: a retrospective cohort study Frontiers in Endocrinology IVF/ICSI progesterone hCG obesity clinical pregnancy |
| title | Effect of BMI on the value of serum progesterone to predict clinical pregnancy outcome in IVF/ICSI cycles: a retrospective cohort study |
| title_full | Effect of BMI on the value of serum progesterone to predict clinical pregnancy outcome in IVF/ICSI cycles: a retrospective cohort study |
| title_fullStr | Effect of BMI on the value of serum progesterone to predict clinical pregnancy outcome in IVF/ICSI cycles: a retrospective cohort study |
| title_full_unstemmed | Effect of BMI on the value of serum progesterone to predict clinical pregnancy outcome in IVF/ICSI cycles: a retrospective cohort study |
| title_short | Effect of BMI on the value of serum progesterone to predict clinical pregnancy outcome in IVF/ICSI cycles: a retrospective cohort study |
| title_sort | effect of bmi on the value of serum progesterone to predict clinical pregnancy outcome in ivf icsi cycles a retrospective cohort study |
| topic | IVF/ICSI progesterone hCG obesity clinical pregnancy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1162302/full |
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