Changes in erythrocyte deformability in patients with T2DM are associated with RBC energy metabolism
Objective To investigate the relationship between erythrocyte (RBC) deformability and RBC energy metabolism in patients with type 2 diabetes mellitus (T2DM). Methods Totally 80 T2DM and 50 controls with age of 40 to 70 years were selected. Rough hematology laboratory test, ATP content, Hexokinase...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2021-02-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a200420.pdf |
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| author | SUN Ming-yue, LI Xu-yan, SA Ru-la, LI Jing-jing, LIANG Hao, YAN Zhao-li, SU Yan |
| author_facet | SUN Ming-yue, LI Xu-yan, SA Ru-la, LI Jing-jing, LIANG Hao, YAN Zhao-li, SU Yan |
| author_sort | SUN Ming-yue, LI Xu-yan, SA Ru-la, LI Jing-jing, LIANG Hao, YAN Zhao-li, SU Yan |
| collection | DOAJ |
| description | Objective To investigate the relationship between erythrocyte (RBC) deformability and RBC energy metabolism in patients with type 2 diabetes mellitus (T2DM). Methods Totally 80 T2DM and 50 controls with age of 40 to 70 years were selected. Rough hematology laboratory test, ATP content, Hexokinase (HK) and Pyruvate kinase (PK) activity were detected.Results BMI, DBP and SBP of patients with T2DM were higher than those of control group (P＜0.05). T2DM of RBC deformation index (TK), rigidity index(IR), RBC distribution width (RDW) and average RBC volume (MCV) were higher than that of control group (P＜0.05); The content of ATP and PK activity in RBC of T2DM group were higher than that of control group (P＜0.05), while the activity of HK was lower than that of control group(P＜0.05). In the T2DM, TK was negatively correlated with ATP content and HK activity, and positively correlated with HbA1c. IR was negatively correlated with HK and PK values, and positively correlated with HbA1c (P＜0.05). Compared with Group A, the TK value of Group C increased (P＜0.05) in the HbA1c group. Compared with Group A, Group C had higher ATP, PK and HK (P＜0.05). Compared with Group A, ROS in Group C increased (P＜0.05). Results RCD damage in diabetic patients is closely related to HbA1c, and RBC energy metabolism plays an important role in maintaining RCD. In diabetic patients, ATP production in RBC increased, PK activity increased, and energy metabolism was vigorous, but this did not improve the reduced RCD status caused by high glucose. Conclusions The energy metabolism of erythrocytes in diabetic patients was more vigorous and is closely related to the decrease of RCD. RCD reduction is a risk factor for diabetic microangiopathy, so monitoring erythrocytes energy metabolism may provide a new basis for monitoring the progress of clinical diabetes patients and support clinical diagnosis and treatment. |
| first_indexed | 2024-03-08T16:55:23Z |
| format | Article |
| id | doaj.art-decc4c1e5bd14522b4981f5e8acbc05c |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:55:23Z |
| publishDate | 2021-02-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-decc4c1e5bd14522b4981f5e8acbc05c2024-01-05T03:04:29ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252021-02-01412245249Changes in erythrocyte deformability in patients with T2DM are associated with RBC energy metabolismSUN Ming-yue, LI Xu-yan, SA Ru-la, LI Jing-jing, LIANG Hao, YAN Zhao-li, SU Yan01. Department of Biochemistry and Molecular Biology, Baotou Medical College, Baotou 014000; ;2. Department of Endocrinology, the First Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000; ;3. Class 13, Clinical Medicine 2017, Baotou Medical College, Baotou 014000, ChinaObjective To investigate the relationship between erythrocyte (RBC) deformability and RBC energy metabolism in patients with type 2 diabetes mellitus (T2DM). Methods Totally 80 T2DM and 50 controls with age of 40 to 70 years were selected. Rough hematology laboratory test, ATP content, Hexokinase (HK) and Pyruvate kinase (PK) activity were detected.Results BMI, DBP and SBP of patients with T2DM were higher than those of control group (P＜0.05). T2DM of RBC deformation index (TK), rigidity index(IR), RBC distribution width (RDW) and average RBC volume (MCV) were higher than that of control group (P＜0.05); The content of ATP and PK activity in RBC of T2DM group were higher than that of control group (P＜0.05), while the activity of HK was lower than that of control group(P＜0.05). In the T2DM, TK was negatively correlated with ATP content and HK activity, and positively correlated with HbA1c. IR was negatively correlated with HK and PK values, and positively correlated with HbA1c (P＜0.05). Compared with Group A, the TK value of Group C increased (P＜0.05) in the HbA1c group. Compared with Group A, Group C had higher ATP, PK and HK (P＜0.05). Compared with Group A, ROS in Group C increased (P＜0.05). Results RCD damage in diabetic patients is closely related to HbA1c, and RBC energy metabolism plays an important role in maintaining RCD. In diabetic patients, ATP production in RBC increased, PK activity increased, and energy metabolism was vigorous, but this did not improve the reduced RCD status caused by high glucose. Conclusions The energy metabolism of erythrocytes in diabetic patients was more vigorous and is closely related to the decrease of RCD. RCD reduction is a risk factor for diabetic microangiopathy, so monitoring erythrocytes energy metabolism may provide a new basis for monitoring the progress of clinical diabetes patients and support clinical diagnosis and treatment.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a200420.pdftype 2 diabetes mellitus|red blood cells|energy metabolism|glycolytic key enzyme|red cell deformability |
| spellingShingle | SUN Ming-yue, LI Xu-yan, SA Ru-la, LI Jing-jing, LIANG Hao, YAN Zhao-li, SU Yan Changes in erythrocyte deformability in patients with T2DM are associated with RBC energy metabolism Jichu yixue yu linchuang type 2 diabetes mellitus|red blood cells|energy metabolism|glycolytic key enzyme|red cell deformability |
| title | Changes in erythrocyte deformability in patients with T2DM are associated with RBC energy metabolism |
| title_full | Changes in erythrocyte deformability in patients with T2DM are associated with RBC energy metabolism |
| title_fullStr | Changes in erythrocyte deformability in patients with T2DM are associated with RBC energy metabolism |
| title_full_unstemmed | Changes in erythrocyte deformability in patients with T2DM are associated with RBC energy metabolism |
| title_short | Changes in erythrocyte deformability in patients with T2DM are associated with RBC energy metabolism |
| title_sort | changes in erythrocyte deformability in patients with t2dm are associated with rbc energy metabolism |
| topic | type 2 diabetes mellitus|red blood cells|energy metabolism|glycolytic key enzyme|red cell deformability |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a200420.pdf |
| work_keys_str_mv | AT sunmingyuelixuyansarulalijingjinglianghaoyanzhaolisuyan changesinerythrocytedeformabilityinpatientswitht2dmareassociatedwithrbcenergymetabolism |