AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity

AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity

Abstract Background N-arachidonoylphenolamine (AM404), a paracetamol metabolite, is a potent agonist of the transient receptor potential vanilloid type 1 (TRPV1) and low-affinity ligand of the cannabinoid receptor type 1 (CB1). There is evidence that AM404 exerts its pharmacological effects in immun...

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Bibliographic Details
Main Authors: Soraya Wilke Saliba, Ariel R. Marcotegui, Ellen Fortwängler, Johannes Ditrich, Juan Carlos Perazzo, Eduardo Muñoz, Antônio Carlos Pinheiro de Oliveira, Bernd L. Fiebich
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Journal of Neuroinflammation
Subjects:
AM404
Acetaminophen
Microglia
Inflammation
Prostaglandins
Cyclooxygenase
Online Access:http://link.springer.com/article/10.1186/s12974-017-1014-3

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