Evaluation of strontium aluminate phosphorescent effect on blood as potential light source for phototherapy
Phototherapy has shown its effect on cell stimulation and inhibition based on Arndt-Schulz model. Even though this therapeutic method has apparent effect, but it has limitations for epithelial application due to limitations on light penetration. Hence, with the ideology of fully overcoming this limi...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2020-10-01
|
| Series: | Biomedical Photonics |
| Subjects: | |
| Online Access: | https://www.pdt-journal.com/jour/article/view/440 |
| _version_ | 1797883666167234560 |
|---|---|
| author | Heng Jie Choong Nursakinah Suardi Naser M. Ahmed |
| author_facet | Heng Jie Choong Nursakinah Suardi Naser M. Ahmed |
| author_sort | Heng Jie Choong |
| collection | DOAJ |
| description | Phototherapy has shown its effect on cell stimulation and inhibition based on Arndt-Schulz model. Even though this therapeutic method has apparent effect, but it has limitations for epithelial application due to limitations on light penetration. Hence, with the ideology of fully overcoming this limitation, phosphorescent powder (strontium aluminate) is proposed as the potential light source that emitting photon from inside the body for phototherapy purposes. The strontium aluminate powder used in the experiment has the highest peak absorption at wavelength around 650 nm and lowest at around 350 nm. According to FESEM images, the powder has the particle size varies from 10 to 50 μm at cubic phase. The assessment is done by studying the effect on erythrocyte after blood plasma is irradiated by strontium aluminate powder’s photon. The powder luminesces with a maximum at 491.5 nm when pumped with 473 nm laser at 100 mW in fixed amount of 0.005±0.001 g. Later, it is mixed with centrifuged blood plasma for a predetermined time period (5, 10, 15, and 20 minutes). From this study, it shows that 5 minutes irradiation is the optimum period for erythrocyte in term of morphology enhancement and increase of UV-visible absorption spectrum with at least 21% in comparing with control blood. While the significant increment located at wavelengths 340 nm and 414 nm with both increased by 54% and 41%, respectively. However, for 10 minutes and beyond, the irradiation leads to morphology deterioration while the UV-visible spectrum decrement starts at 15 minutes and beyond. In conjunction, a comparison between blood plasma that either interacted with powder emitting photon or powder with no emission shows that photon emission plays a role in the phototherapy effect. |
| first_indexed | 2024-04-10T03:55:27Z |
| format | Article |
| id | doaj.art-dece6cb366b4439bb9b60bdae6734277 |
| institution | Directory Open Access Journal |
| issn | 2413-9432 |
| language | Russian |
| last_indexed | 2024-04-10T03:55:27Z |
| publishDate | 2020-10-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj.art-dece6cb366b4439bb9b60bdae67342772023-03-13T07:12:31ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322020-10-0193212910.24931/2413-9432-2020-9-3-21-29212Evaluation of strontium aluminate phosphorescent effect on blood as potential light source for phototherapyHeng Jie Choong0Nursakinah Suardi1Naser M. Ahmed2Научный университет МалайзииНаучный университет МалайзииНаучный университет МалайзииPhototherapy has shown its effect on cell stimulation and inhibition based on Arndt-Schulz model. Even though this therapeutic method has apparent effect, but it has limitations for epithelial application due to limitations on light penetration. Hence, with the ideology of fully overcoming this limitation, phosphorescent powder (strontium aluminate) is proposed as the potential light source that emitting photon from inside the body for phototherapy purposes. The strontium aluminate powder used in the experiment has the highest peak absorption at wavelength around 650 nm and lowest at around 350 nm. According to FESEM images, the powder has the particle size varies from 10 to 50 μm at cubic phase. The assessment is done by studying the effect on erythrocyte after blood plasma is irradiated by strontium aluminate powder’s photon. The powder luminesces with a maximum at 491.5 nm when pumped with 473 nm laser at 100 mW in fixed amount of 0.005±0.001 g. Later, it is mixed with centrifuged blood plasma for a predetermined time period (5, 10, 15, and 20 minutes). From this study, it shows that 5 minutes irradiation is the optimum period for erythrocyte in term of morphology enhancement and increase of UV-visible absorption spectrum with at least 21% in comparing with control blood. While the significant increment located at wavelengths 340 nm and 414 nm with both increased by 54% and 41%, respectively. However, for 10 minutes and beyond, the irradiation leads to morphology deterioration while the UV-visible spectrum decrement starts at 15 minutes and beyond. In conjunction, a comparison between blood plasma that either interacted with powder emitting photon or powder with no emission shows that photon emission plays a role in the phototherapy effect.https://www.pdt-journal.com/jour/article/view/440фототерапияфосфоресценциякрасные кровяные клеткиуф-спектроскопияаутофлуоресценциялазер |
| spellingShingle | Heng Jie Choong Nursakinah Suardi Naser M. Ahmed Evaluation of strontium aluminate phosphorescent effect on blood as potential light source for phototherapy Biomedical Photonics фототерапия фосфоресценция красные кровяные клетки уф-спектроскопия аутофлуоресценция лазер |
| title | Evaluation of strontium aluminate phosphorescent effect on blood as potential light source for phototherapy |
| title_full | Evaluation of strontium aluminate phosphorescent effect on blood as potential light source for phototherapy |
| title_fullStr | Evaluation of strontium aluminate phosphorescent effect on blood as potential light source for phototherapy |
| title_full_unstemmed | Evaluation of strontium aluminate phosphorescent effect on blood as potential light source for phototherapy |
| title_short | Evaluation of strontium aluminate phosphorescent effect on blood as potential light source for phototherapy |
| title_sort | evaluation of strontium aluminate phosphorescent effect on blood as potential light source for phototherapy |
| topic | фототерапия фосфоресценция красные кровяные клетки уф-спектроскопия аутофлуоресценция лазер |
| url | https://www.pdt-journal.com/jour/article/view/440 |
| work_keys_str_mv | AT hengjiechoong evaluationofstrontiumaluminatephosphorescenteffectonbloodaspotentiallightsourceforphototherapy AT nursakinahsuardi evaluationofstrontiumaluminatephosphorescenteffectonbloodaspotentiallightsourceforphototherapy AT nasermahmed evaluationofstrontiumaluminatephosphorescenteffectonbloodaspotentiallightsourceforphototherapy |