Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal

Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal

Adeno-associated viruses (AAV) are important vectors for gene therapy, and accordingly, many aspects of their cell transduction pathway have been well characterized. However, the specific mechanisms that AAV virions use to enter the host nucleus remain largely unresolved. We therefore aimed to revea...

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Bibliographic Details
Main Authors: Mikayla Hoad, Emily M. Cross, Camilla M. Donnelly, Subir Sarker, Justin A. Roby, Jade K. Forwood
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
Adeno-associated virus
importin alpha
nuclear localization
binding interface
structure
Online Access:https://www.mdpi.com/1999-4915/15/2/315

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https://www.mdpi.com/1999-4915/15/2/315

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