Searching for drug leads targeted to the hydrophobic cleft of dengue virus capsid protein

Searching for drug leads targeted to the hydrophobic cleft of dengue virus capsid protein

We synthesised and screened 18 aromatic derivatives of guanylhydrazones and oximes aromatic for their capacity to bind to dengue virus capsid protein (DENVC). The intended therapeutic target was the hydrophobic cleft of DENVC, which is a region responsible for its anchoring in lipid droplets in the...

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Bibliographic Details
Main Authors: Liliane O. Ortlieb, Ícaro P. Caruso, Nathane C. Mebus-Antunes, Andrea T. Da Poian, Elaine da C. Petronilho, José Daniel Figueroa-Villar, Claudia J. Nascimento, Fabio C. L. Almeida
Format: Article
Language:English
Published: Taylor & Francis Group 2022-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
dengue virus
denvc
nmr
drug-ligand interaction
fluorescence
Online Access:http://dx.doi.org/10.1080/14756366.2021.2004591

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