New bone-like tissue formation in calcific tendinopathy: A case report
Currently, the pathogenesis of nontraumatic heterotopic ossification (HO), e.g., bone-like tissue in calcific tendinopathy remains unclear. Here, we report a 75-year-old, right-handed Japanese woman who had been on hemodialysis for 3 years and was admitted to our hospital to evaluate pain and swelli...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Bone Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S235218722100317X |
| _version_ | 1819155989504458752 |
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| author | Masaki Hatano Izuru Kitajima Seizo Yamamoto Masaki Nakamura Kazuya Isawa Yutaka Hirota Tatsuya Suwabe Junichi Hoshino Naoki Sawa Yoshihumi Ubara |
| author_facet | Masaki Hatano Izuru Kitajima Seizo Yamamoto Masaki Nakamura Kazuya Isawa Yutaka Hirota Tatsuya Suwabe Junichi Hoshino Naoki Sawa Yoshihumi Ubara |
| author_sort | Masaki Hatano |
| collection | DOAJ |
| description | Currently, the pathogenesis of nontraumatic heterotopic ossification (HO), e.g., bone-like tissue in calcific tendinopathy remains unclear. Here, we report a 75-year-old, right-handed Japanese woman who had been on hemodialysis for 3 years and was admitted to our hospital to evaluate pain and swelling of the right forearm. She worked as a cook, and her main job over the 3 most recent years had been the frequent and continuous shredding of cabbage. A radiograph showed the highly radiopaque material on the dorsal aspect of the right wrist and in the right shoulder. The biopsy of this radiopaque material revealed HO with marrow, as well as calcified material. Histomorphometric analysis of the HO identified a severe type of osteitis fibrosa with a fibrous tissue volume to total volume of 19.8% (>0.5% required for diagnosis) and an osteoid volume to bone volume of 20.0% (>15% required for diagnosis). We found more woven bone-like tissue than lamellar bone-like tissue. However, the intact parathyroid hormone level was 3-times the normal upper limit with 203 pg/mL, but histomorphometric analysis of the right iliac crest revealed normal bone structure. These findings indicate that the frequent and continuous shredding action with the right hand contributed to the nontraumatic HO localized on the dorsal aspect of the right wrist. |
| first_indexed | 2024-12-22T15:45:44Z |
| format | Article |
| id | doaj.art-ded2a085952745c59b198b1a33d71550 |
| institution | Directory Open Access Journal |
| issn | 2352-1872 |
| language | English |
| last_indexed | 2024-12-22T15:45:44Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj.art-ded2a085952745c59b198b1a33d715502022-12-21T18:21:02ZengElsevierBone Reports2352-18722021-06-0114101062New bone-like tissue formation in calcific tendinopathy: A case reportMasaki Hatano0Izuru Kitajima1Seizo Yamamoto2Masaki Nakamura3Kazuya Isawa4Yutaka Hirota5Tatsuya Suwabe6Junichi Hoshino7Naoki Sawa8Yoshihumi Ubara9Department of Orthopaedic Surgery, Toranomon Hospital, Tokyo, Japan; Corresponding authors at: Department of Orthopaedic Surgery, Department of Nephrology Center, Toranomon Hospital, Kajigaya, 1-3-1, Takatsu, Kawasaki, Kanagawa 212-0015, Japan.Department of Orthopaedic Surgery, Toranomon Hospital, Tokyo, JapanDepartment of Orthopaedic Surgery, Toranomon Hospital, Tokyo, JapanDepartment of Orthopaedic Surgery, Toranomon Hospital, Tokyo, JapanDepartment of Orthopaedic Surgery, Toranomon Hospital, Tokyo, JapanDepartment of Orthopaedic Surgery, Toranomon Hospital, Tokyo, JapanDepartment of Nephrology Center, Toranomon Hospital, Tokyo, Japan; Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, JapanDepartment of Nephrology Center, Toranomon Hospital, Tokyo, Japan; Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, JapanDepartment of Nephrology Center, Toranomon Hospital, Tokyo, Japan; Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, JapanDepartment of Nephrology Center, Toranomon Hospital, Tokyo, Japan; Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan; Corresponding authors at: Department of Orthopaedic Surgery, Department of Nephrology Center, Toranomon Hospital, Kajigaya, 1-3-1, Takatsu, Kawasaki, Kanagawa 212-0015, Japan.Currently, the pathogenesis of nontraumatic heterotopic ossification (HO), e.g., bone-like tissue in calcific tendinopathy remains unclear. Here, we report a 75-year-old, right-handed Japanese woman who had been on hemodialysis for 3 years and was admitted to our hospital to evaluate pain and swelling of the right forearm. She worked as a cook, and her main job over the 3 most recent years had been the frequent and continuous shredding of cabbage. A radiograph showed the highly radiopaque material on the dorsal aspect of the right wrist and in the right shoulder. The biopsy of this radiopaque material revealed HO with marrow, as well as calcified material. Histomorphometric analysis of the HO identified a severe type of osteitis fibrosa with a fibrous tissue volume to total volume of 19.8% (>0.5% required for diagnosis) and an osteoid volume to bone volume of 20.0% (>15% required for diagnosis). We found more woven bone-like tissue than lamellar bone-like tissue. However, the intact parathyroid hormone level was 3-times the normal upper limit with 203 pg/mL, but histomorphometric analysis of the right iliac crest revealed normal bone structure. These findings indicate that the frequent and continuous shredding action with the right hand contributed to the nontraumatic HO localized on the dorsal aspect of the right wrist.http://www.sciencedirect.com/science/article/pii/S235218722100317XBone histomorphometryHeterotopic ossificationNew bone-like tissue formationCalcific tendinopathy |
| spellingShingle | Masaki Hatano Izuru Kitajima Seizo Yamamoto Masaki Nakamura Kazuya Isawa Yutaka Hirota Tatsuya Suwabe Junichi Hoshino Naoki Sawa Yoshihumi Ubara New bone-like tissue formation in calcific tendinopathy: A case report Bone Reports Bone histomorphometry Heterotopic ossification New bone-like tissue formation Calcific tendinopathy |
| title | New bone-like tissue formation in calcific tendinopathy: A case report |
| title_full | New bone-like tissue formation in calcific tendinopathy: A case report |
| title_fullStr | New bone-like tissue formation in calcific tendinopathy: A case report |
| title_full_unstemmed | New bone-like tissue formation in calcific tendinopathy: A case report |
| title_short | New bone-like tissue formation in calcific tendinopathy: A case report |
| title_sort | new bone like tissue formation in calcific tendinopathy a case report |
| topic | Bone histomorphometry Heterotopic ossification New bone-like tissue formation Calcific tendinopathy |
| url | http://www.sciencedirect.com/science/article/pii/S235218722100317X |
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