Prenatal Exposure to Air Pollution and Immune Thrombocytopenia: A Nationwide Population-Based Cohort Study
IntroductionImmune thrombocytopenia (ITP) is one of the most common hematologic disorders in children. However, its etiology is still unclear. Epidemiological studies have shown that air pollution is a plausible risk factor in stimulation of oxidative stress, induction of inflammation, and onset of...
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.837101/full |
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| author | Hsin-Chien Yen Chien-Heng Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ya-Chi Hsu Yi-Hsuan Lin |
| author_facet | Hsin-Chien Yen Chien-Heng Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ya-Chi Hsu Yi-Hsuan Lin |
| author_sort | Hsin-Chien Yen |
| collection | DOAJ |
| description | IntroductionImmune thrombocytopenia (ITP) is one of the most common hematologic disorders in children. However, its etiology is still unclear. Epidemiological studies have shown that air pollution is a plausible risk factor in stimulation of oxidative stress, induction of inflammation, and onset of autoimmune diseases. The objective of this article is to examine the effects of prenatal exposure to air pollution on the occurrence of immune thrombocytopenia (ITP) in children.Materials and MethodsThis is a nationwide, population-based, matched case-control study. Using data from Taiwan’s Maternal and Child Health Database (MCHD), we identified 427 children with ITP less than 6 years of age and age-matched controls without ITP between 2004 and 2016. Levels of prenatal exposure to air pollutants were obtained from 71 Environmental Protection Administration monitoring stations across Taiwan according to the maternal residence during pregnancy. Patients who had outpatient visits or admission with diagnosis of ITP and subsequently received first-line treatment of intravenous immunoglobulin or oral glucocorticoids were defined as incidence cases.ResultsPrenatal exposure to particulate matter <10 μm (PM10) in diameter and the pollutant standard index (PSI) increased the risk of childhood ITP. Conversely, carbon monoxide (CO) exposure during pregnancy was negatively associated with the development of ITP.ConclusionCertain prenatal air pollutant exposure may increase the incidence of ITP in children. |
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| last_indexed | 2024-12-13T00:54:20Z |
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| series | Frontiers in Pediatrics |
| spelling | doaj.art-ded39c98a577400f8a0f64fc1bcb08a92022-12-22T00:04:50ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-03-011010.3389/fped.2022.837101837101Prenatal Exposure to Air Pollution and Immune Thrombocytopenia: A Nationwide Population-Based Cohort StudyHsin-Chien Yen0Chien-Heng Lin1Ming-Chih Lin2Ming-Chih Lin3Ming-Chih Lin4Ming-Chih Lin5Ming-Chih Lin6Ya-Chi Hsu7Yi-Hsuan Lin8Children’s Medical Center, Taichung Veterans General Hospital, Taichung City, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung City, TaiwanChildren’s Medical Center, Taichung Veterans General Hospital, Taichung City, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei City, TaiwanDepartment of Food and Nutrition, Providence University, Taichung City, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung City, TaiwanDepartment of Post-baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung City, TaiwanChildren’s Medical Center, Taichung Veterans General Hospital, Taichung City, TaiwanChildren’s Medical Center, Taichung Veterans General Hospital, Taichung City, TaiwanIntroductionImmune thrombocytopenia (ITP) is one of the most common hematologic disorders in children. However, its etiology is still unclear. Epidemiological studies have shown that air pollution is a plausible risk factor in stimulation of oxidative stress, induction of inflammation, and onset of autoimmune diseases. The objective of this article is to examine the effects of prenatal exposure to air pollution on the occurrence of immune thrombocytopenia (ITP) in children.Materials and MethodsThis is a nationwide, population-based, matched case-control study. Using data from Taiwan’s Maternal and Child Health Database (MCHD), we identified 427 children with ITP less than 6 years of age and age-matched controls without ITP between 2004 and 2016. Levels of prenatal exposure to air pollutants were obtained from 71 Environmental Protection Administration monitoring stations across Taiwan according to the maternal residence during pregnancy. Patients who had outpatient visits or admission with diagnosis of ITP and subsequently received first-line treatment of intravenous immunoglobulin or oral glucocorticoids were defined as incidence cases.ResultsPrenatal exposure to particulate matter <10 μm (PM10) in diameter and the pollutant standard index (PSI) increased the risk of childhood ITP. Conversely, carbon monoxide (CO) exposure during pregnancy was negatively associated with the development of ITP.ConclusionCertain prenatal air pollutant exposure may increase the incidence of ITP in children.https://www.frontiersin.org/articles/10.3389/fped.2022.837101/fullimmune thrombocytopenia (ITP)air pollutionprenatal exposurechildrenpollutant standard index (PSI)PM10 |
| spellingShingle | Hsin-Chien Yen Chien-Heng Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ya-Chi Hsu Yi-Hsuan Lin Prenatal Exposure to Air Pollution and Immune Thrombocytopenia: A Nationwide Population-Based Cohort Study Frontiers in Pediatrics immune thrombocytopenia (ITP) air pollution prenatal exposure children pollutant standard index (PSI) PM10 |
| title | Prenatal Exposure to Air Pollution and Immune Thrombocytopenia: A Nationwide Population-Based Cohort Study |
| title_full | Prenatal Exposure to Air Pollution and Immune Thrombocytopenia: A Nationwide Population-Based Cohort Study |
| title_fullStr | Prenatal Exposure to Air Pollution and Immune Thrombocytopenia: A Nationwide Population-Based Cohort Study |
| title_full_unstemmed | Prenatal Exposure to Air Pollution and Immune Thrombocytopenia: A Nationwide Population-Based Cohort Study |
| title_short | Prenatal Exposure to Air Pollution and Immune Thrombocytopenia: A Nationwide Population-Based Cohort Study |
| title_sort | prenatal exposure to air pollution and immune thrombocytopenia a nationwide population based cohort study |
| topic | immune thrombocytopenia (ITP) air pollution prenatal exposure children pollutant standard index (PSI) PM10 |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.837101/full |
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