PPARγ negatively regulates T cell activation to prevent follicular helper T cells and germinal center formation.

PPARγ negatively regulates T cell activation to prevent follicular helper T cells and germinal center formation.

Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor that regulates lipid and glucose metabolism. Although studies of PPARγ ligands have demonstrated its regulatory functions in inflammation and adaptive immunity, its intrinsic role in T cells and autoimmunity has yet t...

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Bibliographic Details
Main Authors: Hong-Jai Park, Do-Hyun Kim, Jin-Young Choi, Won-Ju Kim, Ji Yun Kim, Alireza G Senejani, Soo Seok Hwang, Lark Kyun Kim, Zuzana Tobiasova, Gap Ryol Lee, Joseph Craft, Alfred L M Bothwell, Je-Min Choi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4055678?pdf=render

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