Regulation of microRNA expression and function by nuclear receptor signaling
<p>Abstract</p> <p>MicroRNAs (miRNAs) are small non-coding RNA transcripts that affect various cellular pathways by serving as regulators of gene expression at the translational and transcriptional level. Nuclear receptors (NRs) are ligand-activated transcription factors that regul...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2011-09-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | http://www.cellandbioscience.com/content/1/1/31 |
| _version_ | 1828260594053021696 |
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| author | Yang Zhihong Wang Li |
| author_facet | Yang Zhihong Wang Li |
| author_sort | Yang Zhihong |
| collection | DOAJ |
| description | <p>Abstract</p> <p>MicroRNAs (miRNAs) are small non-coding RNA transcripts that affect various cellular pathways by serving as regulators of gene expression at the translational and transcriptional level. Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene transcription by binding to the promoter region or by interacting with other transcription factors. NRs can regulate miRNA expression either at the transcriptional level, or through posttranscriptional maturation by interacting with miRNA processing factors. This review will summarize recent advances in knowledge of the modulation of miRNA expression by NRs. Increased understanding of the molecular basis of miRNA expression may enable new therapeutic interventions that modulate miRNA activities through NR-mediated signaling.</p> |
| first_indexed | 2024-04-13T03:25:32Z |
| format | Article |
| id | doaj.art-ded651deb2bc418988a3472bb1afc2c6 |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-04-13T03:25:32Z |
| publishDate | 2011-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-ded651deb2bc418988a3472bb1afc2c62022-12-22T03:04:40ZengBMCCell & Bioscience2045-37012011-09-01113110.1186/2045-3701-1-31Regulation of microRNA expression and function by nuclear receptor signalingYang ZhihongWang Li<p>Abstract</p> <p>MicroRNAs (miRNAs) are small non-coding RNA transcripts that affect various cellular pathways by serving as regulators of gene expression at the translational and transcriptional level. Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene transcription by binding to the promoter region or by interacting with other transcription factors. NRs can regulate miRNA expression either at the transcriptional level, or through posttranscriptional maturation by interacting with miRNA processing factors. This review will summarize recent advances in knowledge of the modulation of miRNA expression by NRs. Increased understanding of the molecular basis of miRNA expression may enable new therapeutic interventions that modulate miRNA activities through NR-mediated signaling.</p>http://www.cellandbioscience.com/content/1/1/31miRNAsnuclear receptorsgene regulation |
| spellingShingle | Yang Zhihong Wang Li Regulation of microRNA expression and function by nuclear receptor signaling Cell & Bioscience miRNAs nuclear receptors gene regulation |
| title | Regulation of microRNA expression and function by nuclear receptor signaling |
| title_full | Regulation of microRNA expression and function by nuclear receptor signaling |
| title_fullStr | Regulation of microRNA expression and function by nuclear receptor signaling |
| title_full_unstemmed | Regulation of microRNA expression and function by nuclear receptor signaling |
| title_short | Regulation of microRNA expression and function by nuclear receptor signaling |
| title_sort | regulation of microrna expression and function by nuclear receptor signaling |
| topic | miRNAs nuclear receptors gene regulation |
| url | http://www.cellandbioscience.com/content/1/1/31 |
| work_keys_str_mv | AT yangzhihong regulationofmicrornaexpressionandfunctionbynuclearreceptorsignaling AT wangli regulationofmicrornaexpressionandfunctionbynuclearreceptorsignaling |