Hybrid Formation and Fusion of Cancer Cells In Vitro and In Vivo
The generation of cancer hybrid cells by intra-tumoral cell fusion opens new avenues for tumor plasticity to develop cancer stem cells with altered properties, to escape from immune surveillance, to change metastatic behavior, and to broaden drug responsiveness/resistance. Genomic instability and ch...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/17/4496 |
| _version_ | 1797521553091461120 |
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| author | Ralf Hass Juliane von der Ohe Thomas Dittmar |
| author_facet | Ralf Hass Juliane von der Ohe Thomas Dittmar |
| author_sort | Ralf Hass |
| collection | DOAJ |
| description | The generation of cancer hybrid cells by intra-tumoral cell fusion opens new avenues for tumor plasticity to develop cancer stem cells with altered properties, to escape from immune surveillance, to change metastatic behavior, and to broaden drug responsiveness/resistance. Genomic instability and chromosomal rearrangements in bi- or multinucleated aneuploid cancer hybrid cells contribute to these new functions. However, the significance of cell fusion in tumorigenesis is controversial with respect to the low frequency of cancer cell fusion events and a clonal advantage of surviving cancer hybrid cells following a post-hybrid selection process. This review highlights alternative processes of cancer hybrid cell development such as entosis, emperipolesis, cannibalism, therapy-induced polyploidization/endoreduplication, horizontal or lateral gene transfer, and focusses on the predominant mechanisms of cell fusion. Based upon new properties of cancer hybrid cells the arising clinical consequences of the subsequent tumor heterogeneity after cancer cell fusion represent a major therapeutic challenge. |
| first_indexed | 2024-03-10T08:15:07Z |
| format | Article |
| id | doaj.art-ded65a51312d4a98896ac704868180f2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T08:15:07Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ded65a51312d4a98896ac704868180f22023-11-22T10:28:17ZengMDPI AGCancers2072-66942021-09-011317449610.3390/cancers13174496Hybrid Formation and Fusion of Cancer Cells In Vitro and In VivoRalf Hass0Juliane von der Ohe1Thomas Dittmar2Biochemistry and Tumor Biology Laboratory, Department of Obstetrics and Gynecology, Hannover Medical School, 30625 Hannover, GermanyBiochemistry and Tumor Biology Laboratory, Department of Obstetrics and Gynecology, Hannover Medical School, 30625 Hannover, GermanyInstitute of Immunology, Center of Biomedical Education and Research (ZABF), Witten/Herdecke University, 58448 Witten, GermanyThe generation of cancer hybrid cells by intra-tumoral cell fusion opens new avenues for tumor plasticity to develop cancer stem cells with altered properties, to escape from immune surveillance, to change metastatic behavior, and to broaden drug responsiveness/resistance. Genomic instability and chromosomal rearrangements in bi- or multinucleated aneuploid cancer hybrid cells contribute to these new functions. However, the significance of cell fusion in tumorigenesis is controversial with respect to the low frequency of cancer cell fusion events and a clonal advantage of surviving cancer hybrid cells following a post-hybrid selection process. This review highlights alternative processes of cancer hybrid cell development such as entosis, emperipolesis, cannibalism, therapy-induced polyploidization/endoreduplication, horizontal or lateral gene transfer, and focusses on the predominant mechanisms of cell fusion. Based upon new properties of cancer hybrid cells the arising clinical consequences of the subsequent tumor heterogeneity after cancer cell fusion represent a major therapeutic challenge.https://www.mdpi.com/2072-6694/13/17/4496hybrid cell formationhorizontal gene transfer/lateral gene transfermesenchymal stroma-/stem-like cellsheterokaryon-to-synkaryon transitioncell fusion |
| spellingShingle | Ralf Hass Juliane von der Ohe Thomas Dittmar Hybrid Formation and Fusion of Cancer Cells In Vitro and In Vivo Cancers hybrid cell formation horizontal gene transfer/lateral gene transfer mesenchymal stroma-/stem-like cells heterokaryon-to-synkaryon transition cell fusion |
| title | Hybrid Formation and Fusion of Cancer Cells In Vitro and In Vivo |
| title_full | Hybrid Formation and Fusion of Cancer Cells In Vitro and In Vivo |
| title_fullStr | Hybrid Formation and Fusion of Cancer Cells In Vitro and In Vivo |
| title_full_unstemmed | Hybrid Formation and Fusion of Cancer Cells In Vitro and In Vivo |
| title_short | Hybrid Formation and Fusion of Cancer Cells In Vitro and In Vivo |
| title_sort | hybrid formation and fusion of cancer cells in vitro and in vivo |
| topic | hybrid cell formation horizontal gene transfer/lateral gene transfer mesenchymal stroma-/stem-like cells heterokaryon-to-synkaryon transition cell fusion |
| url | https://www.mdpi.com/2072-6694/13/17/4496 |
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