The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC)
Breast cancer is a leadingcause of cancer-related deaths in women globally, with triple-negative breast cancer (TNBC) being an aggressive subtype that lacks targeted therapies and is associated with a poor prognosis. Polyphenols, naturally occurring compounds in plants, have been investigated as a p...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223009617 |
| _version_ | 1797744095443025920 |
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| author | Reyhaneh Farghadani Rakesh Naidu |
| author_facet | Reyhaneh Farghadani Rakesh Naidu |
| author_sort | Reyhaneh Farghadani |
| collection | DOAJ |
| description | Breast cancer is a leadingcause of cancer-related deaths in women globally, with triple-negative breast cancer (TNBC) being an aggressive subtype that lacks targeted therapies and is associated with a poor prognosis. Polyphenols, naturally occurring compounds in plants, have been investigated as a potential therapeutic strategy for TNBC. This review provides an overview of the anticancer effects of polyphenols in TNBC and their mechanisms of action. Several polyphenols, including resveratrol, quercetin, kaempferol, genistein, epigallocatechin-3-gallate, apigenin, fisetin, hesperetin and luteolin, have been shown to inhibit TNBC cell proliferation, induce cell cycle arrest, promote apoptosis, and suppress migration/invasion in preclinical models. The molecular mechanisms underlying their anticancer effects involve the modulation of several signalling pathways, such as PI3K/Akt, MAPK, STATT, and NF-κB pathways. Polyphenols also exhibit synergistic effects with chemotherapy drugs, making them promising candidates for combination therapy. The review also highlights clinical trials investigating the potential use of polyphenols, individually or in combination therapy, against breast cancer. This review deepens the under-standing of the mechanism of action of respective polyphenols and provides valuable insights into the potential use of polyphenols as a therapeutic strategy for TNBC, and lays the groundwork for future research in this area. |
| first_indexed | 2024-03-12T15:04:49Z |
| format | Article |
| id | doaj.art-ded69c218eb74b62b96149a98265d9db |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T15:04:49Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-ded69c218eb74b62b96149a98265d9db2023-08-13T04:52:51ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-09-01165115170The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC)Reyhaneh Farghadani0Rakesh Naidu1Corresponding authors.; Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 47500, MalaysiaCorresponding authors.; Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 47500, MalaysiaBreast cancer is a leadingcause of cancer-related deaths in women globally, with triple-negative breast cancer (TNBC) being an aggressive subtype that lacks targeted therapies and is associated with a poor prognosis. Polyphenols, naturally occurring compounds in plants, have been investigated as a potential therapeutic strategy for TNBC. This review provides an overview of the anticancer effects of polyphenols in TNBC and their mechanisms of action. Several polyphenols, including resveratrol, quercetin, kaempferol, genistein, epigallocatechin-3-gallate, apigenin, fisetin, hesperetin and luteolin, have been shown to inhibit TNBC cell proliferation, induce cell cycle arrest, promote apoptosis, and suppress migration/invasion in preclinical models. The molecular mechanisms underlying their anticancer effects involve the modulation of several signalling pathways, such as PI3K/Akt, MAPK, STATT, and NF-κB pathways. Polyphenols also exhibit synergistic effects with chemotherapy drugs, making them promising candidates for combination therapy. The review also highlights clinical trials investigating the potential use of polyphenols, individually or in combination therapy, against breast cancer. This review deepens the under-standing of the mechanism of action of respective polyphenols and provides valuable insights into the potential use of polyphenols as a therapeutic strategy for TNBC, and lays the groundwork for future research in this area.http://www.sciencedirect.com/science/article/pii/S0753332223009617Anticancer agentPhytochemicalsChemosensitivityStilbenesFlavonoidsHormone receptor-negative |
| spellingShingle | Reyhaneh Farghadani Rakesh Naidu The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC) Biomedicine & Pharmacotherapy Anticancer agent Phytochemicals Chemosensitivity Stilbenes Flavonoids Hormone receptor-negative |
| title | The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC) |
| title_full | The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC) |
| title_fullStr | The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC) |
| title_full_unstemmed | The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC) |
| title_short | The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC) |
| title_sort | anticancer mechanism of action of selected polyphenols in triple negative breast cancer tnbc |
| topic | Anticancer agent Phytochemicals Chemosensitivity Stilbenes Flavonoids Hormone receptor-negative |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223009617 |
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