Peri-Ictal Changes in Depression and Anxiety in Persons With Epileptic and Non-epileptic Seizures
ObjectiveWe tested the hypothesis that epileptic, but not non-epileptic, seizures would produce an improvement in comorbid depression and anxiety symptoms in the peri-ictal period, much like the antidepressant effects of electroconvulsive therapy.MethodsWe examined depression and anxiety symptoms in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.912697/full |
| _version_ | 1828786036312899584 |
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| author | Jennifer Hopp Autusa Pahlavan Mary Richert Kathryn Grimes Kate Turlington Maureen Cassady Mark D. Kvarta Mark D. Kvarta Scott M. Thompson Scott M. Thompson |
| author_facet | Jennifer Hopp Autusa Pahlavan Mary Richert Kathryn Grimes Kate Turlington Maureen Cassady Mark D. Kvarta Mark D. Kvarta Scott M. Thompson Scott M. Thompson |
| author_sort | Jennifer Hopp |
| collection | DOAJ |
| description | ObjectiveWe tested the hypothesis that epileptic, but not non-epileptic, seizures would produce an improvement in comorbid depression and anxiety symptoms in the peri-ictal period, much like the antidepressant effects of electroconvulsive therapy.MethodsWe examined depression and anxiety symptoms in patients admitted to an inpatient unit for continuous video electroencephalography as part of routine clinical care. Patients completed three questionnaires that included the Beck Depression Inventory-II (BDI), Montgomery Asberg Depression Rating Scale (MADRS), and Beck Anxiety Inventory (BAI) after admission, in the 24 h following a seizure, then again 2 weeks after the last seizure.ResultsIn patients with epilepsy, depression and anxiety scores improved in the 24 hrs following a seizure (change in BDI = 24%; change in MADRS = 19%; change in BAI = 21%) but returned toward baseline after 2 weeks. In patients with non-epileptic seizures, depression and anxiety scores also improved in the 24 hrs following a psychogenic non-epileptic seizure (change in BDI = 17%, change in MADRS = 27%, change in BAI = 36%). There was a greater improvement in depression and anxiety scores in patients with focal-onset epilepsy (BDI = 30%, MADRS = 22%, BAI = 30%) compared to generalized seizure onset (BDI = 6%, MADRS = 12%, BAI = 8%).ConclusionWe conclude that single seizures can result in transient improvements in mood. Because seizures need not be generalized or epileptic to exert this effect, the underlying mechanisms are uncertain. |
| first_indexed | 2024-12-12T00:03:14Z |
| format | Article |
| id | doaj.art-dedad720ecf34c619bec8b53855eb9a5 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-12T00:03:14Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-dedad720ecf34c619bec8b53855eb9a52022-12-22T00:45:11ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-07-011310.3389/fpsyt.2022.912697912697Peri-Ictal Changes in Depression and Anxiety in Persons With Epileptic and Non-epileptic SeizuresJennifer Hopp0Autusa Pahlavan1Mary Richert2Kathryn Grimes3Kate Turlington4Maureen Cassady5Mark D. Kvarta6Mark D. Kvarta7Scott M. Thompson8Scott M. Thompson9Division of Epilepsy, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United StatesDivision of Epilepsy, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United StatesDivision of Epilepsy, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United StatesDivision of Epilepsy, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Pediatrics, University of Virginia, Charlottesville, VA, United StatesDivision of Epilepsy, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Physiology, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Physiology, University of Maryland School of Medicine, Baltimore, MD, United StatesObjectiveWe tested the hypothesis that epileptic, but not non-epileptic, seizures would produce an improvement in comorbid depression and anxiety symptoms in the peri-ictal period, much like the antidepressant effects of electroconvulsive therapy.MethodsWe examined depression and anxiety symptoms in patients admitted to an inpatient unit for continuous video electroencephalography as part of routine clinical care. Patients completed three questionnaires that included the Beck Depression Inventory-II (BDI), Montgomery Asberg Depression Rating Scale (MADRS), and Beck Anxiety Inventory (BAI) after admission, in the 24 h following a seizure, then again 2 weeks after the last seizure.ResultsIn patients with epilepsy, depression and anxiety scores improved in the 24 hrs following a seizure (change in BDI = 24%; change in MADRS = 19%; change in BAI = 21%) but returned toward baseline after 2 weeks. In patients with non-epileptic seizures, depression and anxiety scores also improved in the 24 hrs following a psychogenic non-epileptic seizure (change in BDI = 17%, change in MADRS = 27%, change in BAI = 36%). There was a greater improvement in depression and anxiety scores in patients with focal-onset epilepsy (BDI = 30%, MADRS = 22%, BAI = 30%) compared to generalized seizure onset (BDI = 6%, MADRS = 12%, BAI = 8%).ConclusionWe conclude that single seizures can result in transient improvements in mood. Because seizures need not be generalized or epileptic to exert this effect, the underlying mechanisms are uncertain.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.912697/fullgeneralized epilepsiespsychogenic seizuredepressionanxietyfocal epilepsies |
| spellingShingle | Jennifer Hopp Autusa Pahlavan Mary Richert Kathryn Grimes Kate Turlington Maureen Cassady Mark D. Kvarta Mark D. Kvarta Scott M. Thompson Scott M. Thompson Peri-Ictal Changes in Depression and Anxiety in Persons With Epileptic and Non-epileptic Seizures Frontiers in Psychiatry generalized epilepsies psychogenic seizure depression anxiety focal epilepsies |
| title | Peri-Ictal Changes in Depression and Anxiety in Persons With Epileptic and Non-epileptic Seizures |
| title_full | Peri-Ictal Changes in Depression and Anxiety in Persons With Epileptic and Non-epileptic Seizures |
| title_fullStr | Peri-Ictal Changes in Depression and Anxiety in Persons With Epileptic and Non-epileptic Seizures |
| title_full_unstemmed | Peri-Ictal Changes in Depression and Anxiety in Persons With Epileptic and Non-epileptic Seizures |
| title_short | Peri-Ictal Changes in Depression and Anxiety in Persons With Epileptic and Non-epileptic Seizures |
| title_sort | peri ictal changes in depression and anxiety in persons with epileptic and non epileptic seizures |
| topic | generalized epilepsies psychogenic seizure depression anxiety focal epilepsies |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.912697/full |
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